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Loperamide
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Reactions 1002 - 22 May 2004 ★ S Loperamide First report of anaphylaxis in a child: case report A 10-year-old boy developed anaphylaxis after receiving oral loperamide 2mg for acute gastroenteritis. He had previously received loperamide without experiencing any adverse effects. Five minutes after receiving the dose of loperamide, the boy developed nasal congestion, rhinorrhoea, dyspnoea, wheezing, cough, cyanosis of the lips, oedema of the right eyelid and a generalised erythematous macular eruption. He was treated with parenteral antihistamines and corticosteroids and improved within 2–3hours. One year after the episode of anaphylaxis, the boy underwent skin prick and intradermal testing. Skin prick tests with loperamide 2 mg/mL and other pethidine [meperidine] derivatives (pethidine, fentanyl and alfentanil) were all negative. Intradermal tests were positive with loperamide 0.02 mg/mL, but were negative for other pethidine derivatives. Author comment: "The clinical history, the previous administration of loperamide with no ill-effects and the results of intradermal tests suggest an immunoglobulin E- mediated process." P´ erez-Calder´ on R, et al. Anaphylaxis due to loperamide. Allergy 59: 369-370, No. 3, Mar 2004 - Spain 800974202 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of anaphylaxis associated with loperamide. The WHO Adverse Drug Reaction database contained nine reports of anaphylactic shock and 21 reports of anaphylactoid reaction associated with loperamide. 1 Reactions 22 May 2004 No. 1002 0114-9954/10/1002-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Loperamide
Reactions 1002 - 22 May 2004
★ SLoperamide
First report of anaphylaxis in a child: case reportA 10-year-old boy developed anaphylaxis after receiving oral
loperamide 2mg for acute gastroenteritis. He had previouslyreceived loperamide without experiencing any adverse effects.
Five minutes after receiving the dose of loperamide, the boydeveloped nasal congestion, rhinorrhoea, dyspnoea,wheezing, cough, cyanosis of the lips, oedema of the righteyelid and a generalised erythematous macular eruption. Hewas treated with parenteral antihistamines and corticosteroidsand improved within 2–3hours.
One year after the episode of anaphylaxis, the boyunderwent skin prick and intradermal testing. Skin prick testswith loperamide 2 mg/mL and other pethidine [meperidine]derivatives (pethidine, fentanyl and alfentanil) were allnegative. Intradermal tests were positive with loperamide0.02 mg/mL, but were negative for other pethidine derivatives.
Author comment: "The clinical history, the previousadministration of loperamide with no ill-effects and theresults of intradermal tests suggest an immunoglobulin E-mediated process."Perez-Calderon R, et al. Anaphylaxis due to loperamide. Allergy 59: 369-370, No.3, Mar 2004 - Spain 800974202
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of anaphylaxis associatedwith loperamide. The WHO Adverse Drug Reaction databasecontained nine reports of anaphylactic shock and 21 reports ofanaphylactoid reaction associated with loperamide.
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Reactions 22 May 2004 No. 10020114-9954/10/1002-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
