Reactions 1383 - 7 Jan 2012

Octreotide

Nevus: case reportA 52-year-old man, who had started receiving IM

octreotide [Sandostatin SR] 30mg monthly as adjuvanttreatment for hepatic metastases a year earlier, developedmultiple nevi (more than 200 lesions) over his torso andback. His nevi were flat and pigmented, and some were ofthe lentigo type. Two clinically atypical lesions wereexcised, and histological examinations showed benign,hyperpigmented levi; magnification of a nevus showednumerous peripheral pseudopods over the entirecircumference. The number of his nevi had stabilised, andhe was monitored for more than 10 years while onoctreotide therapy. He had not developed melanoma.Michel J-L. Eruptive naevi associated with octreotide treatment. Annales deDermatologie et de Venereologie 138: 677-680, No. 10, Oct 2011. Available from:URL: http://dx.doi.org/10.1016/j.annder.2011.05.010 [French; summarised from atranslation] - France 803064381

» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports of naevusassociated with octreotide. The WHO ADR databasecontained 3 reports of melanocytic naevus associated withoctreotide.

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Reactions 7 Jan 2012 No. 13830114-9954/10/1383-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved