Octreotide
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Reactions 1386 - 28 Jan 2012 S Octreotide Seizures in a child: case report A 6-year-old girl developed seizures after receiving octreotide. The girl developed acute pancreatitis caused by asparaginase and started receiving a continuous IV infusion of octreotide 3.6 µg/kg/day. Four days later, she had an episode of generalised tonic-clonic seizures with loss of awareness. During the episode, she had rolling eyes, urinary incontinence, rhythmic jerking and muscle spasms. The girl received diazepam, but rhythmic muscle contractions persisted for more than 10 minutes. She received IV phenytoin and in a few minutes the seizure resolved.Two hours later, she had a second episode, with movement of her legs, lip smacking and repeated swallowing. She received diazepam and responded quickly. For the next 2 days, she was hypertensive and confused. Four days after the first seizure episode, she had a third episode in her sleep, which resolved after a few minutes with diazepam. An EEG showed frontotemporal sharp waves on her right hemisphere at a frequency of 1.5–2 Hz. Octreotide was discontinued. Three days after the last seizure episode, levetiracetam was started. Her symptoms gradually improved and, 1 month later, clinical analysis was normal. Seven months after the seizures, her EEG was normal. One month later, levetiracetam was stopped. Hatzipantelis E, et al. Epileptic seizures after octreotide administration in a 6.5-year-old female with ALL and L-asparaginase associated pancreatitis: A possible drug interaction. Klinische Padiatrie 223: 360-363, No. 6, Jan 2011. Available from: URL: http://dx.doi.org/10.1055/s-0031-1287827 - Greece 803066419 1 Reactions 28 Jan 2012 No. 1386 0114-9954/10/1386-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Octreotide
Reactions 1386 - 28 Jan 2012
SOctreotide
Seizures in a child: case reportA 6-year-old girl developed seizures after receiving
octreotide.The girl developed acute pancreatitis caused by
asparaginase and started receiving a continuous IV infusionof octreotide 3.6 µg/kg/day. Four days later, she had anepisode of generalised tonic-clonic seizures with loss ofawareness. During the episode, she had rolling eyes,urinary incontinence, rhythmic jerking and muscle spasms.
The girl received diazepam, but rhythmic musclecontractions persisted for more than 10 minutes. Shereceived IV phenytoin and in a few minutes the seizureresolved.Two hours later, she had a second episode, withmovement of her legs, lip smacking and repeatedswallowing. She received diazepam and respondedquickly. For the next 2 days, she was hypertensive andconfused. Four days after the first seizure episode, she hada third episode in her sleep, which resolved after a fewminutes with diazepam. An EEG showed frontotemporalsharp waves on her right hemisphere at a frequency of1.5–2 Hz. Octreotide was discontinued. Three days afterthe last seizure episode, levetiracetam was started. Hersymptoms gradually improved and, 1 month later, clinicalanalysis was normal. Seven months after the seizures, herEEG was normal. One month later, levetiracetam wasstopped.Hatzipantelis E, et al. Epileptic seizures after octreotide administration in a6.5-year-old female with ALL and L-asparaginase associated pancreatitis: Apossible drug interaction. Klinische Padiatrie 223: 360-363, No. 6, Jan 2011.Available from: URL: http://dx.doi.org/10.1055/s-0031-1287827 -Greece 803066419
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Reactions 28 Jan 2012 No. 13860114-9954/10/1386-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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