Octreotide
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Reactions 408 - 4 Jul 1992 Octreotide Cholelithiasis: incidence study Long-term octreotide (’Sandostatin’) increases the risk of cholelithiasis in patients with, and in those without, acromegaly, say Australian researchers. These researchers studied 11 men and 4 women with acromegaly (mean age 50 years) who received SC octreotide 100-500mcg tid for 4-32 months and 10 men with obstructive sleep apnoea (mean age 51 years) who received octreotide 100mcg bid for 2-3 months. The overall incidence of cholelithiasis was 32%, occurring in 6 patients with acromegaly and 2 patients with sleep apnoea; the between- group difference was not significant. Fasting gall bladder volume significantly increased during treatment with octreotide, but normalised after treatment withdrawal. Gall stones completely resolved in 6/7 patients with new gall stones who were studied for </= 8 months after octreotide withdrawal Bigg-Wither GW, et al. Effects of long term octreotide on gall stone formation and gall bladder function. BMJ 304: 1611-1612, 20 Jun 1992 - Australia 800150064 1 Reactions 4 Jul 1992 No. 408 0114-9954/10/0408-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Octreotide
Reactions 408 - 4 Jul 1992
Octreotide
Cholelithiasis: incidence studyLong-term octreotide (’Sandostatin’) increases the risk of
cholelithiasis in patients with, and in those without,acromegaly, say Australian researchers.
These researchers studied 11 men and 4 women withacromegaly (mean age 50 years) who received SC octreotide100-500mcg tid for 4-32 months and 10 men with obstructivesleep apnoea (mean age 51 years) who received octreotide100mcg bid for 2-3 months. The overall incidence ofcholelithiasis was 32%, occurring in 6 patients withacromegaly and 2 patients with sleep apnoea; the between-group difference was not significant.
Fasting gall bladder volume significantly increased duringtreatment with octreotide, but normalised after treatmentwithdrawal. Gall stones completely resolved in 6/7 patientswith new gall stones who were studied for </= 8 months afteroctreotide withdrawalBigg-Wither GW, et al. Effects of long term octreotide on gall stone formation andgall bladder function. BMJ 304: 1611-1612, 20 Jun 1992 - Australia 800150064
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Reactions 4 Jul 1992 No. 4080114-9954/10/0408-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
