Octreotide
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Reactions 1384 - 14 Jan 2012 ★ S Octreotide First report of mesenteric ischaemia: case report A 62-year-old woman, whose history included coronary artery disease, underwent coronary artery bypass grafting and started receiving SC octreotide 100µg three times daily for chylomediastinum on postoperative day 7. She developed loose, watery stools and mild rectal bleeding 2 days later. The following day, right lower quadrant pain with guarding and rebound tenderness emerged, and her WBC count increased from 16 to 40.2/mm 3 . A diagnostic laparoscopy showed caecal ischaemia, and she underwent caecectomy. She recovered, and her chylomediastinum spontaneously resolved over the following week. Author comment: "It is possible that the patient described above suffered from mesenteric vascular disease in addition to coronary artery disease. The reduction of splanchnic blood flow by octreotide may have precipitated mesenteric ischemia in this patient." Rotman S, et al. Ischemic Bowel in a Post-cardiac Surgery Patient Treated with Octreotide. 76th Annual Scientific Meeting of the American College of Gastroenterology : abstr. P559, 28 Oct 2011. Available from: URL: http:// download.abstractcentral.com/ACG2011/proofs/P559.html [abstract] - USA 803065756 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of mesenteric ischaemia associated with octreotide. The WHO ADR database contained three reports of intestinal ischaemia associated with octreotide. 1 Reactions 14 Jan 2012 No. 1384 0114-9954/10/1384-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
Transcript of Octreotide
Reactions 1384 - 14 Jan 2012
★ SOctreotide
First report of mesenteric ischaemia: case reportA 62-year-old woman, whose history included coronary
artery disease, underwent coronary artery bypass graftingand started receiving SC octreotide 100µg three times dailyfor chylomediastinum on postoperative day 7. Shedeveloped loose, watery stools and mild rectal bleeding2 days later. The following day, right lower quadrant painwith guarding and rebound tenderness emerged, and herWBC count increased from 16 to 40.2/mm3. A diagnosticlaparoscopy showed caecal ischaemia, and she underwentcaecectomy. She recovered, and her chylomediastinumspontaneously resolved over the following week.
Author comment: "It is possible that the patient describedabove suffered from mesenteric vascular disease in additionto coronary artery disease. The reduction of splanchnic bloodflow by octreotide may have precipitated mesenteric ischemiain this patient."Rotman S, et al. Ischemic Bowel in a Post-cardiac Surgery Patient Treated withOctreotide. 76th Annual Scientific Meeting of the American College ofGastroenterology : abstr. P559, 28 Oct 2011. Available from: URL: http://download.abstractcentral.com/ACG2011/proofs/P559.html [abstract] -USA 803065756
» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports ofmesenteric ischaemia associated with octreotide. The WHOADR database contained three reports of intestinal ischaemiaassociated with octreotide.
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Reactions 14 Jan 2012 No. 13840114-9954/10/1384-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
