Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch,...

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Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl, Monique M.A. Verstegen, Ewa Ellis, Martien van Wenum, Sabine A. Fuchs, Joep de Ligt, Marc van de Wetering, Nobuo Sasaki, Susanne J. Boers, Hans Kemperman, Jeroen de Jonge, Jan N.M. Ijzermans, Edward E.S. Nieuwenhuis, Ruurdtje Hoekstra, Stephen Strom, Robert R.G. Vries, Luc J.W. van der Laan, Edwin Cuppen, Hans Clevers Cell Volume 160, Issue 1, Pages 299-312 (January 2015) DOI: 10.1016/j.cell.2014.11.050 Copyright © 2015 The Authors Terms and Conditions

Transcript of Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch,...

Page 1: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver 

Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl, Monique M.A. Verstegen, Ewa Ellis, Martien van Wenum, Sabine A. Fuchs, Joep de Ligt, Marc van de Wetering, Nobuo Sasaki, Susanne J. Boers, Hans Kemperman, Jeroen

de Jonge, Jan N.M. Ijzermans, Edward E.S. Nieuwenhuis, Ruurdtje Hoekstra, Stephen Strom, Robert R.G. Vries, Luc J.W. van der Laan, Edwin Cuppen, Hans Clevers 

Cell Volume 160, Issue 1, Pages 299-312 (January 2015)

DOI: 10.1016/j.cell.2014.11.050

Copyright © 2015 The Authors Terms and Conditions

Page 2: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure 1

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 3: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure 2

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 4: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure 3

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 5: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure 4

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 6: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure 5

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 7: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure 6

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 8: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure 7

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 9: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure S1

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 10: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure S2

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 11: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure S3

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 12: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure S4

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 13: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure S5

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 14: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure S6

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 15: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Figure S7

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions

Page 16: Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, Karien Hamer, Francis Blokzijl,

Cell 2015 160, 299-312DOI: (10.1016/j.cell.2014.11.050) Copyright © 2015 The Authors Terms and Conditions