Yu Zhao1†, Zixian Zhao1†, Yujia Wang1†, Yueqing Zhou1, Yu Ma2, Wei Zuo1,3,4*

1. Shanghai East Hospital, School of Medicine, Tongji University, 200433 Shanghai,

China

2. Regend Therapeutics, 245000 Suzhou, China

3. State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of

Guangzhou Medical University, 510120 Guangzhou, China

4. Ningxia Medical University, 750004 Yingchuan, China

*Correspondence to: zuow@tongji.edu.cn (Wei Zuo)

† These authors contribute equally to this work.

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(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint

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(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The copyright holder for this preprintthis version posted April 9, 2020. . https://doi.org/10.1101/2020.01.26.919985doi: bioRxiv preprint