Octreotide
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Reactions 383 - 11 Jan 1992 ★ Octreotide First report of biliary colic: 4 case reports Abrupt withdrawal of octreotide (’Sandostatin’) in 4 patients with acromegaly, was followed, 12-16 hours later, by sudden, severe hypochondrial pain of 15-180 min duration, then diarrhoea. All patients recovered spontaneously within 24 hours and 1 patient reported a similar event when octreotide therapy had been previously stopped suddenly. All 4 patients had developed biliary calculi. ’These four cases of biliary colic point to a possible adverse effect of rebound gallbladder hypercontractility occurring about 12 hours after abrupt cessation of octreotide.’ James RA, et al. Biliary colic in abrupt withdrawal of octreotide. Lancet 338: 1527, 14 Dec 1991 - United Kingdom 800113229 1 Reactions 11 Jan 1992 No. 383 0114-9954/10/0383-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Octreotide
Reactions 383 - 11 Jan 1992
★Octreotide
First report of biliary colic: 4 case reportsAbrupt withdrawal of octreotide (’Sandostatin’) in 4 patients
with acromegaly, was followed, 12-16 hours later, by sudden,severe hypochondrial pain of 15-180 min duration, thendiarrhoea. All patients recovered spontaneously within 24hours and 1 patient reported a similar event when octreotidetherapy had been previously stopped suddenly. All 4 patientshad developed biliary calculi.
’These four cases of biliary colic point to a possible adverseeffect of rebound gallbladder hypercontractility occurringabout 12 hours after abrupt cessation of octreotide.’James RA, et al. Biliary colic in abrupt withdrawal of octreotide. Lancet 338:1527, 14 Dec 1991 - United Kingdom 800113229
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Reactions 11 Jan 1992 No. 3830114-9954/10/0383-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
