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Loperamide
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Reactions 1060 - 16 Jul 2005 ★ Loperamide First report of a fixed drug eruption: case report A 58-year-old woman developed a fixed drug eruption associated with loperamide [therapeutic indication not stated]. The woman, who had been self-administering loperamide, ibuprofen, tetrazepam and paracetamol [acetaminophen]/ codeine [dosages and duration of treatment not stated], presented with multiple flat, symmetrical, purplish-red lesions in the intergluteal and groin areas. Her skin eruption was diagnosed as a fixed drug eruption. All of the woman’s medications were discontinued and her skin eruption resolved within 9 days. One month later, she presented with a skin eruption identical in appearance and location to the previous skin eruption. She reported having taken two or three loperamide 2mg tablets a few days before symptom onset. Loperamide was discontinued and her skin eruption resolved after 10 days. Author comment: The imputability of loperamide and fixed drug eruption was analysed using Naranjo’s method of estimating the probability of adverse drug effects, which gave a result of "probable" causality. Matarredona J, et al. Fixed drug eruption caused by loperamide. Medicina Clinica 124: 198-199, No. 5, 12 Feb 2005 [Spanish; summarised from a translation] - Spain 807220146 » Editorial comment: A search of AdisBase and Medline did not reveal any previous case reports of fixed drug eruptions associated with loperamide. The WHO Adverse Drug Reactions database contained 100 reports of rash and five of fixed eruption associated with loperamide. 1 Reactions 16 Jul 2005 No. 1060 0114-9954/10/1060-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Loperamide
Reactions 1060 - 16 Jul 2005
★Loperamide
First report of a fixed drug eruption: case reportA 58-year-old woman developed a fixed drug eruption
associated with loperamide [therapeutic indication not stated].The woman, who had been self-administering loperamide,
ibuprofen, tetrazepam and paracetamol [acetaminophen]/codeine [dosages and duration of treatment not stated],presented with multiple flat, symmetrical, purplish-red lesionsin the intergluteal and groin areas. Her skin eruption wasdiagnosed as a fixed drug eruption.
All of the woman’s medications were discontinued and herskin eruption resolved within 9 days. One month later, shepresented with a skin eruption identical in appearance andlocation to the previous skin eruption. She reported havingtaken two or three loperamide 2mg tablets a few days beforesymptom onset. Loperamide was discontinued and her skineruption resolved after 10 days.
Author comment: The imputability of loperamide andfixed drug eruption was analysed using Naranjo’s method ofestimating the probability of adverse drug effects, which gavea result of "probable" causality.Matarredona J, et al. Fixed drug eruption caused by loperamide. Medicina Clinica124: 198-199, No. 5, 12 Feb 2005 [Spanish; summarised from a translation] -Spain 807220146
» Editorial comment: A search of AdisBase and Medline didnot reveal any previous case reports of fixed drug eruptionsassociated with loperamide. The WHO Adverse Drug Reactionsdatabase contained 100 reports of rash and five of fixed eruptionassociated with loperamide.
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Reactions 16 Jul 2005 No. 10600114-9954/10/1060-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
