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]SXVC]IGN BCONRIMGNZSA]IZONRC]M:bi`g; D]X,@S,?98@,880 I~~~g}xiro/ ?,,,,,,,,,, ,,,%,,,,,,,,,? BMFG@GROg.m

]ilgn Fgaizov !.&&.!~~~';'/&&&'~DG]XIROAI[OMIGN I Zcv}i:n; ?NCSVGMIVS@iO

ROFAO BC MGNRCNIBG

?. KS]RIJIMOMIGN6. GFKCRIZG]=. XVGJC]IGNOAC] O _SICNC] ZO BIVI@IBG2. XGFAOMIGN BIONO I CTMCXMIGNC]3. LCRGBGAG@IO:. OMRIZIBOBC] 8XVGMCBILICNRG]0. OA@GVIRLG BC OMRSOMIGN4. INBIMOBGVC] BC CZOASOMIGN9. @AG]OVIG I BCJINIMIGNC]?8.FIFAIG@VOJIO??.VC@I]RVG]?6.ONCTG]

CAOFGVG; VCZI]G;

~~,o,Ncsvgmivs joJCMDO;I Cncvg bc 68?6

Xo`ino ? bc :

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M:bi g; D]X,@S,?98@,880SXVC]IGN BCONRIMGNZSA]IZONRC]

O AM Oi...GI O L OY GVGCFG@GROg.m.

~&r.Q.rrI~~&& '>,1~' ,! k ! ! ! ! ; . ! ! ;G',& 'IZN

Dg~'5x?roa j,,,,,,,,,~,,,,,~,%,,,,,WWWWWI]ilgn Fgaizov DG]XIROAI[OMIGN Zcv}ign; ?

NCSVGMIVS@iO

?. KS]RIJIMOMIGNXovo ca lonckg bca `von nsvncvg bc xomicnrc} vcjcvibg} o c}ro an}rirsmrgn! mgn mvi}i}mgnzsa}izo} qsc don }ibc rvorobo} mgn onrimgnzsa}izonrc y oa lglcnro bc }szoagvomi:n c}xcmioai{obo! mgn onrcmcbcnrc bc riclxg loygv bc rvc} lc}c} aifvc} bcmvi}i} mgnzsa}izo}! }c vcqsicvc sno `sio bc lonckg xovo c}ro} }irsomignc} maanimo}cn ca }cvzimig bc Ncsvgmivs`io mgn ca jin bc bcrcvlinov ca lonckg lcbimg xcvrincnrc o}c`siv! cn c}xcmioa rglov sno obcmsobo bcmi}ign oa bcjiniv sno }s}xcn}ign bclcbimolcnrg onrimgnzsa}azonrc.6. GFKCRIZG]Bov mgnrinsibob cn jgvlo inrc`voa oa rvorolicnrg lcbimg 8 qsivsvqimg vcqscvibg xovoc}rc rixg bc xomicnrc}.=. XVGJC]IGNOAC] O _SICNC] ZO BIVI@IBGC}xcmioai}ro} cn Ncsvgmivs`jo! VcdofsiromignX}imgagqg}! Ncsvgxcbiorvo}! Xcbiorvo}.Cnjcvlcvo} Kcjc}! ostiaiovc}.Rvofokobgvo} ]gmvorc}.2. XGFAOMIGN BIONO I CTMCXMIGNC]Xomicnrc} xcbiorvimg} y obsarg}! mgn cxi}gbig} mgnzsa}izg} ng mvgnimg} bcjinibg} cnksnro lcbimo inrcvbi}mixainovio c}xcmioalcnrc bc/ rcvvcng }sfc}xcmioai{obgNcsvgag` jo,cxiacxrgag` ro.Ao Ctmcxmign ivnxaimo mgglgvfiaibob aivvsronrc.3. LCRGBGAG@IO]c xvc}cnron xomicnrc} mgn ac}ignc} cn xovcnqsivno mcvcfvoa! c}xcmioalcnrc cnvc`ignc} jvgnroac} 8 rclxgvoac} qsc }gn oarolcnrc mgnzsa}izgqcno} o ao} msoac} doyqsc }glcrcv fokg ca rvorolicnrg xvgjiaomrimg mgn lcbimolcnrg} onrimgnzsa}izonrc}!cn ca xvgmc}g bc czgasmign maanimo }i ng }c xvc}cnro ca }jnbvglc cxiacxrimg }c bcmibcao caivninomign bca rvorovnicnrg.:. OMRIZIBOBC] 8 XVGMCBILICNRG]Czibcnmio ', Vcmglcnb}mign OInrcvzcnmignc};Bc ag} 3= c}rsbig} cn ao aircvorsvo omrsoa 3= jscvgn bc mao}c II y ? bc mao}c I! }cmgn}ibcvg mglg jomrgvc} o rcncv cn mscnro c/ }ctg! ao cbob! ca rixg bc mvi}i}! ca

Xo`ino 6 bc ]

8/2/2019 HSP-GU-190G-007 Supresion de anticonvulsivantes

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]SXVC]IGN BCONRIMGNZSA]IZONRC]Zcv}i:n; ?

M:bi g; D]X,@S,?98@,880

Dg}xiroa]ilgn Fgaizov

OAMOA.GiO LOYGI'.BC.FG@GRO g.m.

DG]XIR OAi[OMIGNNCSVGMIVS@IO

mgcjimicnrc inrcacmrsoa! ao xvc}cnmio bc bong ncsvga:`img! ca onrimgnzsa}izonrc! cariclxg aifvc bc mvi}i}! ao ngvloaibob bc ca rvo{obg cacmrvgcnmcjoag`vorimg! mgn bimdg}mvircvig} }gag ?0 c}rsbig} mslxaicvgn ag} vcqsi}irg}.]c mgnmisyc qsc ag} xomicnrc cn qsicnc} }c xscbc }sxviliv ;?,cxiacx}io aifvc bc mvi}i} cn sn xcvagbg cnrvc 6 ovic} y 3 ong} $xvglcbig =. ovic})6,Ctolcn ncsvga: img y jj}img ngvloa.=,Rixg snimg bc mvi}i} xovmioac} 8 `cncvoai{obo}.2, Ngvloaibob bc ca rvo{obg cacmrvgcnmcjoag vojimg bc}xsc} bca rvorolicnrg.Czibcnmio ',Vcmglcnbomi:n O]c vcmglicnbo vcrivov cn jgvlo xvg`vc}izo ca onrimgnzsa}izonrc! ng vcoai{ovag cnjgvlo ofvsxro.Czibcnmio ',Vcmglcnbomi:n OVcmglicnbon rcncv nizcac} }cvimg} xvczig} obcmsobg} cn ca lglcnrg bc ao}sxvc}i:n bc ao lcbimomi:n .Czibcnmio II,Vcmglcnbomi:n O

RIXG BC VCMGLCNBOMIGN ??,4Cn ag} xomicnrc} cn qsicnc} xvc}cnron sn bonc ncsvga:`img }sfyomcnrc ng }c ac}bcfc }sxviliv ao lcbimomi:n.Czibcnmio ',Vcmglcnbomi:n OMgn}ibcvomignc} c}xcmioac}Ao }sxvc}i:n mgn fcn{gbio{cxino} y jcngfovfiroa }c bcfc bc vcoai{ov cn jgvlo lo}acnro qsc ca vc}rg bc onrimgnzsa}izonrc} bcfibg o qsc cn xomicnrc} mgn bimdolcbimomi:n ricnc sno vic}`g vcaorizg loygv bc vcmoabo qsc mgn ag} grvg}onrimgnzsa}izonrc}! }c bcfc vcoai{ov cn jgvlo xvg`vc}izo cn sn xcvjgbg cnrvc rvc} o}ci} lc}c}Czibcnmioaa , Vcmglcnbomi:n F.Xvgn:}rimgCn obsarg} cn qsicnc} }c mgnrinso c}ro} }s`cvcnmio} doy sn ctirg cn ca :? # Y ca=9# xvc}cnr: vcmojbo}

Xo`ino = bc :

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OAMOj .. !B$O ! LO. .YGVBCcgggvt g!m.

"O>.OG

]SXVC]IGN BCONRIMGNZSA]IZONRC]

I M:bi g; D]X,@S,??98@,880IDg}xiro/

]ilgn Fgaizov IZ &'I cv}ign; ?WW ?,

DG]XIR OAi[OMIGNNCSVGMIVS@IO

0. OA@GVIRLG BC OMRSOMIGNJaskg`volo

Mgnrvca olfsao;gvigNcsvgilo`cn$VL>ROM)CC@]i ng} bc oa}aj'n}]c biiicvc ca inirig bcrvorolcnrgonrimgnzsa}izonac

Xoqino 2 bc ]

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]SXVC]IGN BCONRIMGNZSA]IZONRC]

M:bi g; D]X,@S,?98@,880

DG]XIROAi[OMIGNNCSVGMIVS@iOII Zcv}i:n; ?

OAMOAGIO. LOYGjrBC.FG@GRO g.m.

M".&AZB~,,,,,,,,,,,,,,,,,,,,,,%,,,,,,,,,,,~

]ilgn Fgaizov

4. INBIMOBGVC] BC CZOASOMIGNNg. bc xomicnrc} orcnbibg} mgn ao xorgag`jo c}xcmijimoboNg. bc xomicnrc} rvorobg} , }s}xcn}ignNg. bc mglxaimomignc}Ng. Bc C`vc}g}.

9. @AG]OVIG I BCJINIMIGNC]CI xomicnrc cxircxrimg aifvc bc mvi}i} bsvonrc sn xcvigbg bcrcvlinonbg. Ng doylsmdg} borg} omcvmo bc ao bcmi}ign bc }sxvc}ign bc ao lcbimomign! c}ro bcfc }cvbcomscvbg o ca xomicnrc y rixg bc cxiacx}io! }c don vcoai{obg c}rsbig} xvg}xcmrizg}y vcrvg}xcmrizg} xcvg ao mglxovomi:n cnrvc c}rg} ng c} jomia! xgv ronrg }c ctxgnbvocn c}ro `sjo sn vc}slcn bc c}rg}.Mvircvig} Baoqng}ramg}Cxiacx}io; c} sn }jnbvglc movomrcvi{obg xgv ao bc}mov`o }inmvgnamo y vcxcririzo bcsn `vsxg bc ncsvgno qsc ricnc lonijc}romignc} majnimo} c}xcmijimo} .Mro}ijamomign bc ao} mvi}i};Ao mao}ijimomign majnimo y cacmrvgcnmcjoag`vojimo} bc ao} mvi}i} cxiacxrimo} cn ?94? }cmao}ijimon cn ;Mvi}i} Xovmioac} ; ]ilxac}; lgrgvo} ! }cn}irizo}! osrgngvnimo}! x}iqsimo}.

Mglxacko}.Mvi}i} @cncvoai{obo}; Rgnimo}! magnimo}! orgnimo}! rgnimgmagnimo}! os}cnmio}!ligmagnimo}.?8. FIFAIG@VOJIO?,Lccrin` Olcvimon Omobcly gj Ncsvgag`y. Vczicp M.B 6.88=.6,Lccrin` Olcvimon Omcbly gj Ncsvgag`y .Vczicp M.B 6.882.=,Mgmdvonc boro fo}c gj }y}rclorim vczicp}. Mgmdvonc aifvovy zgaslc $?) 6.883.2,Fcv` OR! ]dinnov ]. Vcaox}c jgaagpin` bi}mgnrinsorign gj onri cxiacxrim bvs`}; olcro onoay}i}. Ncsvgag`y ?992522;2;:8?,43,]ivzcn KI! ]xcvain` L! Pin`cvmdse GL. Covay zcv}s} aorc onricxiacxrim bvs`pirdbvopoa jgv xcgxac pird cxiacx}y in vcli}}ign $Mgmdvonc Vczicp). Rdc MgmdvoncAifvovy 688=5?;Sxborc ]gjrpovc! Gtjgvb! SE.:, Lcbimoa Vc}covmd Mgsnmia Onricxiacxrim Bvs` Pirdbvopoa ]rsby @vgsx. Xvg`ng}riminbct jgv vcmsvvcnmc gj }ci{svc ojrcv vcli}}ign gj cxiacx}y. FLK ?99=5=8:; ?=02,4 .0,Lcbimoa Vc}covmd Mgsnmia Onricxiicxrim Bvs` Pirdbvopoa ]rsby @vgsx.Vonbgli}cb }rsby gj onricxiacxrim bvs` pirdbvopoa in xoricnr} in vcli}}ign .. Aonmcr?99? 5==0; ??03,48.

Xo`ino 3 bc :

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M:bi`g; D]X,@S,?98@,880SXVC]IGN BCONRIMGNZSA]IZONRC]Dg}xirna

]ilgn Fgaizov I Zcv}i:n; ?G]XIR OAI[OMIGNNCSVGMIVS@iO

OAMOa.I)$O LOYGjirgc cgggv.} g!m.

4, Olcvimon Omobcly gj Ncsvgag`y , _soairy }ronbovb} }sfmgllirrcc. Xvomrimcxovolcrcv; o `sibcainc jgv bi}mgnrinsin` onricxiacxrim bvs`} in }ci{svc,jvcc xoricnr}.Olcvimon Omobcly gj Ncsvgag`y Xvomrimc Xovolcrcv} ?992.

??. VC@I]RVG]Di}rgvio MajnimoCximvi}i}Gvbcn bc ]gaimirsbGvbcn bc ]oaiboJgvlorg bc Jgvlsaomi:n bc Lcbimolcnrg} c In}slg} Lcbimg}Jgvlorg Snimg bc Bczgasmi:n bc Lcbimolcnrg} c In}slg}

?6. ONCTG]C}ro qsao ng `cncvo onctg}

Xoqino : bc :