Post on 06-Jul-2018
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Golongan Obat
Nama Obat Sulfonamide sulsoksazol sulfametoksazol
Kimia
Aktivitas Antimikroba
Spektrum
Farmakodinamik
sulfonamide(antifolat)
sulfanilamid(gugus karboksidigantisulfaamina)
derivatsulsoksazol
Bakteriostatikbakterisid (urindalam kadartinggi)
!uas(S"p#ogenes$S"pneumonia$B"ant%ra&is$'"dip%teriae$"inuenzae$
"du&re#i$Bru&ella$*"&%olera$No&ardia$A&tinom#&etes$'"granulomatis$'"tra&%omatis$kuman enterik)ke&ualipseudomonas$serratia$ proteus$
beberapa straine"&oli
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+etabolisme
7kskresi lebi% lambat
7fek Samping sering kristaluria
8ndikasi
Kontraindikasi
fase 2 (asetilasidan oksidasi)%asil oksidasi
bersifat toksik%asil asetilasimen#ebabkaninaktif
asetilasi tinggi(,adi butu% dosistinggi .9 efeksamping99)
sebagian besargin,al sebagianke&il tin,a$empedu$ AS8
:;3 le<at urin(dosis tunggal)
(;3pasien)anemia%emolitik akut(akibatalergi6def"G=>/)anemia aplastik
(,arang sekali)trombositopeniaringaneosinoliadepresi sumsumtulang (padapasien A8/s)kristaluria alergi(kelainan kulitdemam)%epatitis akibat
toksik(1$23pasien) 43pasien mualmunta%% padaba#i menggeserbilirubin dara%(kerni&terus)
,arang kristaluriaalergi (letal)
pasien 8SK daninfeksi sistemik
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8nteraksi Obat
Bentuk sediaan ;11 mg tablet oral
/osis
arga Obat
Generik
Branded (2)
Branded(4)
antikoagulanoral antidiabetiksulfonilureafenitoin ..9
%ambatmetabolisme ..9kadar obat inimeningkat
oral dapatdiabsorpsi oraltidak dapatdiabsorpsiltopikal
kombinasitrimetropim (diluar negerimengandung ;11mg aktif)
de<asa (4.5 gdia<al dandilan,utkan 2 g tiap5.= ,am) anak(2;1 mg6kgBB satu%ari dengan a<al264 dosis dandilan,utkan 26=
dosis per 5.= ,amper %ari)
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Sulfadiazine Sulfasitin Sulfametizol Sulfasalazin Suksinilsulfatiazol
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lebi% &epatdengan t 264?.= ,am (dosistunggal)
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013 direabsorpsigin,al
sering
kristaluriapada urin&enderungasam (kasi%Na.bikarbonatuntuk naikanp)
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;11 mg tabletoral
de<asa (4.5 gdia<al dandilan,utkan 4.5 g dalam ?.=@ pemberian$lama
pemberiantergantunglamapen#akit)anak 9 4bulan (dosisa<al setenga%dosis per %aridilan,utkan=1.2;1mg6kgBB
dalam 5.=@pemberian)
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Ftalilsulfatiazol Sulfasetamid Ag.Sulfadiazin +afenid Sulfadoksin
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