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Golongan Obat

Nama Obat Sulfonamide sulsoksazol sulfametoksazol

Kimia

Aktivitas Antimikroba

Spektrum

Farmakodinamik

sulfonamide(antifolat)

sulfanilamid(gugus karboksidigantisulfaamina)

derivatsulsoksazol

Bakteriostatikbakterisid (urindalam kadartinggi)

!uas(S"p#ogenes$S"pneumonia$B"ant%ra&is$'"dip%teriae$"inuenzae$

"du&re#i$Bru&ella$*"&%olera$No&ardia$A&tinom#&etes$'"granulomatis$'"tra&%omatis$kuman enterik)ke&ualipseudomonas$serratia$ proteus$

beberapa straine"&oli

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+etabolisme

7kskresi lebi% lambat

7fek Samping sering kristaluria

8ndikasi

Kontraindikasi

fase 2 (asetilasidan oksidasi)%asil oksidasi

bersifat toksik%asil asetilasimen#ebabkaninaktif 

asetilasi tinggi(,adi butu% dosistinggi .9 efeksamping99)

sebagian besargin,al sebagianke&il tin,a$empedu$ AS8

:;3 le<at urin(dosis tunggal)

(;3pasien)anemia%emolitik akut(akibatalergi6def"G=>/)anemia aplastik

(,arang sekali)trombositopeniaringaneosinoliadepresi sumsumtulang (padapasien A8/s)kristaluria alergi(kelainan kulitdemam)%epatitis akibat

toksik(1$23pasien) 43pasien mualmunta%% padaba#i menggeserbilirubin dara%(kerni&terus)

 ,arang kristaluriaalergi (letal)

pasien 8SK daninfeksi sistemik

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8nteraksi Obat

Bentuk sediaan ;11 mg tablet oral

/osis

arga Obat

Generik

Branded (2)

Branded(4)

antikoagulanoral antidiabetiksulfonilureafenitoin ..9

%ambatmetabolisme ..9kadar obat inimeningkat

oral dapatdiabsorpsi oraltidak dapatdiabsorpsiltopikal

kombinasitrimetropim (diluar negerimengandung ;11mg aktif)

de<asa (4.5 gdia<al dandilan,utkan 2 g tiap5.= ,am) anak(2;1 mg6kgBB satu%ari dengan a<al264 dosis dandilan,utkan 26=

dosis per 5.= ,amper %ari)

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Sulfadiazine Sulfasitin Sulfametizol Sulfasalazin Suksinilsulfatiazol

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lebi% &epatdengan t 264?.= ,am (dosistunggal)

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013 direabsorpsigin,al

sering

kristaluriapada urin&enderungasam (kasi%Na.bikarbonatuntuk naikanp)

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;11 mg tabletoral

de<asa (4.5 gdia<al dandilan,utkan 4.5 g dalam ?.=@ pemberian$lama

pemberiantergantunglamapen#akit)anak 9 4bulan (dosisa<al setenga%dosis per %aridilan,utkan=1.2;1mg6kgBB

dalam 5.=@pemberian)

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Ftalilsulfatiazol Sulfasetamid Ag.Sulfadiazin +afenid Sulfadoksin

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