Stem Cell Makers - AbcamRaf sos Grb2 P T B Ras MAPK Ubiquilin Mint - 1 Mint - 2 Mint - 3 Fe65 A I C...
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Raf sos Grb2 P T B Ras MAPK Ubiquilin Mint - 2 Mint - 3 Mint - 1 Fe65 A I C D C PS1 / PS2 Pen-2 Aph - 1α1 Aph - 1α2 Aph - 1β cleavage activates γ - secretase γ - secretase α - secretase β - secretase ADAM10 ADAM17 BACE1 BACE2 - 40 - 42 - 49 CLAC-P Protease α2M Aβ Aβ Aβ Aβ Aβ Aβ Protease IDE Protease NEP Protease PLG N APP NCT OLIGOMERIZATION DEGRADATION CLEARANCE / EXPORT CYTOPLASM Aβ P3 ApoE ApoE SH2 Shc Aβ Aβ Aβ Aβ Aβ Aβ Aβ Aβ Y E N P T Y L R P N O T C H E r b B 4 C D 4 4 P 7 5 N T R γ secretase E - C A D H E R I N Alzheimer’s Disease: Amyloid Precursor Protein (APP) processing
Transcript of Stem Cell Makers - AbcamRaf sos Grb2 P T B Ras MAPK Ubiquilin Mint - 1 Mint - 2 Mint - 3 Fe65 A I C...
Rafsos
Grb2
PTB
Ras
MAPK
Ubiquilin
Mint - 2 Mint - 3Mint - 1
Fe65
AICD
C
PS1 / PS2
Pen-2Aph - 1α1Aph - 1α2Aph - 1β
cleavageactivatesγ - secretase
γ - secretase
α - secretase
β - secretase
ADAM10ADAM17
BACE1
BACE2
- 40- 42- 49
CLAC-P
Protease α2M
Aβ
Aβ Aβ
AβAβ
Aβ
Protease IDE
Protease NEP
Protease PLG
N
APP
NCT
OLIGOMERIZATION DEGRADATIONCLEARANCE / EXPORT
CYTOPLASM
Aβ
P3ApoE
ApoE
SH2
Shc
Aβ
Aβ
Aβ
Aβ Aβ Aβ
Aβ
Aβ
YENPTY
LRP
NOTCH
ErbB4
CD44
P75N
T
R
γ secretase
E-CADHERIN
Alzheimer’s Disease:Amyloid Precursor Protein (APP) processing
