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CLINICAL TOXICOLOGY 9(3), pp. 461-462 (1976) NEWS lTEMS Rotterdamsch Radio-Therapeutischlnstituut Dr. Kingsley Kay Mount Sinai School of Medicine, Department of Community Medicine, Fifth Avenue, 100th Street, New York, New York USA. 29th October 1975 Dear Dr. Kay, At the Workshop on Cancer Registries and Occupational Cancer in Lyon I had the opportunity to meet Dr. Tomatis and ask him his opinion about the possible carcinogenity of some organic dye- stuff pigments, that are used in the Grafic Industry. The motive for this question arose from investigations of occupational histories of bladder cancer patients treated in the Rotterdam Radiotherapy Institute at Rotterdam. From these histories we got the impression that there were more patients with bladder cancer who had worked in the Grafic Industry than might be expected. Closer investigation in printing-offices revealed that in some places there may be a rather intensive exposure of the workers to dye-stuff pigments. Some of these stuffs are derivates of well known carcinogenic aro- matic amines, and so we concluded that the use of some of these pigments might possibly be a carcinogenic hazard for some special jobs in Printing Industry. As far as I know there are no reports of this possibility mentioned in literature. During our discussion Dr. Tomatis told me that you had asked his opinion about the same kind of stuffs used in printing offices. I will be very obliged to hear from you if you have the same suspicion concerning the possibility of the presence of a carcinogenic hazard for the urothelium in the Grafic Industry. Thanking you in advance for your reply, Yours sincerely, W. Fokkens. 46 1 (cont.) Clinical Toxicology Downloaded from informahealthcare.com by York University Libraries on 12/19/14 For personal use only.
Transcript of Rotterdamsch Radio-Therapeutisch Instituut
CLINICAL TOXICOLOGY 9(3), pp. 461-462 (1976)
NEWS lTEMS
Rotterdamsch Radio-Therapeutisch lnstituut
Dr. Kingsley Kay Mount Sinai School of Medicine, Department of Community Medicine, Fifth Avenue, 100th Street, New York, New York USA.
29th October 1975
Dear Dr. Kay,
At the Workshop on Cancer Registries and Occupational Cancer in Lyon I had the opportunity to meet Dr. Tomatis and ask him his opinion about the possible carcinogenity of some organic dye- stuff pigments, that a r e used in the Grafic Industry. The motive for this question arose from investigations of occupational histories of bladder cancer patients treated in the Rotterdam Radiotherapy Institute at Rotterdam. From these histories we got the impression that there were more patients with bladder cancer who had worked in the Grafic Industry than might be expected. Closer investigation in printing-offices revealed that in some places there may be a rather intensive exposure of the workers to dye-stuff pigments. Some of these stuffs a r e derivates of well known carcinogenic aro- matic amines, and s o we concluded that the use of some of these pigments might possibly be a carcinogenic hazard for some special jobs in Printing Industry. As far as I know there are no reports of this possibility mentioned in literature.
During our discussion Dr. Tomatis told me that you had asked h i s opinion about the same kind of stuffs used in printing offices. I will be very obliged to hear from you if you have the same suspicion concerning the possibility of the presence of a carcinogenic hazard for the urothelium in the Grafic Industry.
Thanking you in advance for your reply, Yours sincerely,
W. Fokkens. 46 1 (cont.)
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462 NEWS ITEMS
November 5, 1975
Dr. W. Fokkens Rotterdamsch Radio-Therapeutisch Instituut Groene Hilledijk 301 Postbus 4201 Rotterdam- Zuid
Dear Dr. Fokkens:
With reference to your letter of 29th October, I have been studying the range of chemicals used in the graphics industry. I had no real indication that there was higher than normal incidence of cancer among graphics personnel but I undertook to assemble available data on the carcinogenicity of chemicals used in the industry. A prepublication copy of my report i s enclosed.* I have also assessed textile chemi- cals. Among the 46 dyes used in largest quantity in the United States I could find carcinogenicity test data on only four but of these, three were found positive. Incidentally, no ongoing research has been reported to IARC in regard to any of the thirty-seven ink constituents and the forty-six dyes excepting titanium which I am told by the investigators has thus far proved negative.
I appreciate your letter and hope we may keep in touch a s we seem to be the only investigators covering this aspect of occupational cancer.
Sincerely,
Kingsley K. Kay, Ph. D. Associate Professor
*Article pp. 359 this issue of Clinical Toxicology.
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