Octreotide
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Reactions 456 - 19 Jun 1993 ★ S Octreotide First report of dependence on mechanical ventilation: case report A 65-year-old woman became dependent on mechanical ventilation while she was receiving octreotide (dosage not given) to reduce the output of small bowel contents following a transverse colectomy. After beginning octreotide 5 days’ postoperatively, the woman had periods of atrial fibrillation and chest infections which responded to treatment with amiodarone and antibiotics, respectively. Two weeks’ postoperatively, attempts were made to wean her from ventilatory support; however, these were unsuccessful. Despite continued efforts to withdraw her from the respirator, she was still dependent on ventilator support 6 weeks’ postoperatively. Octreotide was discontinued at this time, and 1 week later the patient was successfully weaned from mechanical ventilation She was able to breathe unaided for the next 11 weeks, when she developed a chest infection. During dialysis she developed refractory hypotension and died. Author comment: ‘To our knowledge, clinically relevant interference with respiration has not previously been described during administration of octreotide.’ Raphael JH. Octreotide and dependence on ventilatory support. European Journal of Anaesthesiology 10: 235-236, May 1993 - England 800202749 1 Reactions 19 Jun 1993 No. 456 0114-9954/10/0456-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Octreotide
Reactions 456 - 19 Jun 1993
★ SOctreotide
First report of dependence on mechanicalventilation: case report
A 65-year-old woman became dependent on mechanicalventilation while she was receiving octreotide (dosage notgiven) to reduce the output of small bowel contents followinga transverse colectomy. After beginning octreotide 5 days’postoperatively, the woman had periods of atrial fibrillationand chest infections which responded to treatment withamiodarone and antibiotics, respectively. Two weeks’postoperatively, attempts were made to wean her fromventilatory support; however, these were unsuccessful.Despite continued efforts to withdraw her from the respirator,she was still dependent on ventilator support 6 weeks’postoperatively. Octreotide was discontinued at this time, and1 week later the patient was successfully weaned frommechanical ventilation She was able to breathe unaided for thenext 11 weeks, when she developed a chest infection. Duringdialysis she developed refractory hypotension and died.
Author comment: ‘To our knowledge, clinically relevantinterference with respiration has not previously beendescribed during administration of octreotide.’Raphael JH. Octreotide and dependence on ventilatory support. European Journalof Anaesthesiology 10: 235-236, May 1993 - England 800202749
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Reactions 19 Jun 1993 No. 4560114-9954/10/0456-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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