Octreotide
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Reactions 1368 - 10 Sep 2011 S Octreotide Thrombocytopenia: case report A 54-year-old man presenting with haematemesis and light-headedness developed thrombocytopenia during treatment with octreotide [indication not clearly stated]. The patient, who had a history of oesophageal varices and alcoholic liver disease, received a 50µg IV bolus of octreotide, followed by a continuous infusion of 50 µg/hour, in addition to saline, packed RBCs, thiamine, folic acid and ciprofloxacin. After 9 hours, his platelet count had decreased from 155 000/mm 3 to 77 000/mm 3 and remained low at approximately 50 000/mm 3 for 3 days after admission. Laboratory tests for acute thrombocytopenia were within normal ranges. A diagnosis of drug-induced thrombocytopenia was presumed. Octreotide therapy was withdrawn 3 days after admission, and rapid improvement was observed. The patient exhibited a platelet count of 114 000/mm 3 and was discharged from hospital 5 days after admission. Rashidi A, et al. Octreotide-induced thrombocytopenia: A case report. Journal of Medical Case Reports 5: No. 286, 5 Jul 2011. Available from: URL: http:// dx.doi.org/10.1186/1752-1947-5-286 - USA 803059642 1 Reactions 10 Sep 2011 No. 1368 0114-9954/10/1368-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
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Transcript of Octreotide
Reactions 1368 - 10 Sep 2011
SOctreotide
Thrombocytopenia: case reportA 54-year-old man presenting with haematemesis and
light-headedness developed thrombocytopenia duringtreatment with octreotide [indication not clearly stated].
The patient, who had a history of oesophageal varicesand alcoholic liver disease, received a 50µg IV bolus ofoctreotide, followed by a continuous infusion of50 µg/hour, in addition to saline, packed RBCs, thiamine,folic acid and ciprofloxacin. After 9 hours, his platelet counthad decreased from 155 000/mm3 to 77 000/mm3 andremained low at approximately 50 000/mm3 for 3 days afteradmission. Laboratory tests for acute thrombocytopeniawere within normal ranges. A diagnosis of drug-inducedthrombocytopenia was presumed.
Octreotide therapy was withdrawn 3 days afteradmission, and rapid improvement was observed. Thepatient exhibited a platelet count of 114 000/mm3 and wasdischarged from hospital 5 days after admission.Rashidi A, et al. Octreotide-induced thrombocytopenia: A case report. Journal ofMedical Case Reports 5: No. 286, 5 Jul 2011. Available from: URL: http://dx.doi.org/10.1186/1752-1947-5-286 - USA 803059642
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Reactions 10 Sep 2011 No. 13680114-9954/10/1368-0001/$14.95 © 2010 Adis Data Information BV. All rights reserved
