Centre de Recherche Facultaire STATQAM
9
Centre de Recherche Facultaire STATQAM Genevi` eve Lefebvre & Jean-Fran¸ cois Coeurjolly Journ´ ee de la recherche - Facult´ e des sciences 12 avril 2019 G Lefebvre & JF Coeurjolly STATQAM 1/9
Transcript of Centre de Recherche Facultaire STATQAM
Centre de Recherche Facultaire STATQAM
Genevieve Lefebvre & Jean-Francois Coeurjolly
Journee de la recherche - Faculte des sciences 12 avril 2019
G Lefebvre & JF Coeurjolly STATQAM 1 / 9
STATQAM2018 - . . .
ÉMoStA2007-2018
Bio(stat)2gen2015-2018
SCADService de
consultation> 30 ans
CRM1968- . . .
CIRGET
LaCIM
Quantact
StatLab
Centre de recherchesmathématiques (CRM)
•Plus de 200 chercheurs•12 principales universités du
Québec et Ontario•UQAM représentée dans 4laboratoires
Laboratoire destatistique
•47 membres réguliers•Concordia, HEC, Laval,
McGill, Sherbrooke, UdM,UQAM
STATQAM en bref
•10 professeurs (7+3, dép.mathématiques)
•⇡ 10-12 étudiants en 3èmecycle et post-doc
•⇡ 15 étudiants à la maîtrise
G Lefebvre & JF Coeurjolly STATQAM 2 / 9
Qui sommes-nous?
Membres reguliers (a�lies au StatLab du CRM, Dep.
mathematiques)
J Atherton, JF Coeurjolly, S Froda, S Guillotte, F Larribe, GLefebvre, K Oualkacha
Membres associes (Dep. mathematiques, pour le moment):
MH Descary, R Ferland et F Watier
) 40% de femmes; la parite jusque dans la direction!
Ou nous rencontrer?
seminaire hebdomadaire de statistique, Dep.mathematiques
parfois specialise et parfois tres interdisciplinaire!
G Lefebvre & JF Coeurjolly STATQAM 3 / 9
Themes de recherche - Champs d’expertise
"BQbi�iBbiB[m2r �bbQ+B�iBQM 2i +�mb�HBiûr ai�iBbiB[m2 ;ûMûiB[m2r �M�Hvb2 /2 bm`pB2 2i/ǶûpĕM2K2Mib ?BbiQ`B[m2br úTB/ûKBQHQ;B2
JQ/ĕH2b � Kûi?Q/2br S`Q+2bbmb biQ+?�biB[m2b, TQM+im2Hb-M�Bbb�M+2 2i KQ`i- 7`�+iBQMM�B`2br *QTmH2b- bi�iBbiB[m2 bT�iB�H2- /B`2+iBQMM2HH2r ai�iBbiB[m2 MQM T�`�Kûi`B[m2- �bvKTiQiB[m2r ai�iBbiB[m2 #�vûbB2MM2
ai�iBbiB[m2 � b+B2M+2 /2b /QMMû2br :`�M/2 /BK2MbBQMr .QMMû2b +QKTH2t2b- 7QM+iBQM2HH2br ai�iBbiB[m2 +QKTmi�iBQMM2HH2 BMi2MbBp2r .ûp2HQTT2K2Mi HQ;B+B2H
istiqueQAM
STATu
G Lefebvre & JF Coeurjolly STATQAM 4 / 9
Réseau decollaborationsSTATQAM
Montréal
Québec-
Canada
International
Pôle montréalais
•UQAM: Département debiologie, ESG
•McGill: StatisticsDepartment, BiostatisticsDepartment
•UdM: Pharmacie,Ste-Justine, CRCHUM
•HEC: Département desciences de la décision
•Lady Davis Institute
Collaborationsnationales
•Univ. Laval,•Univ. Ottawa•Univ. Alberta•Simon Fraser Univ.
Sources de financement
•CRSNG, IRSC•FRQNT, FRQS• INCASS (Institut national canadien de la
science statistique)•Centre de recherches mathématiques/CNRS•Génome Canada•UQAM
Collaborationsinternationales
•USA: Ohio State Univ.,Miami Univ., Johns Hopkins(Pub. Health)
•Australie: Curtin Univ.•Danemark: Aalborg Univ.•France: Univ. Nantes, Lille,
Grenoble, Lyon•UK: Newcastle Univ.•Maroc: Univ. Marrakech
G Lefebvre & JF Coeurjolly STATQAM 5 / 9
1. Analyse de donnees epidemiologiques et cliniques
Exemple de jeux de donnees:
> 7000 grossesses defemmes asthmatiques(RAMQ, Med-Echo)
250 survivants deleucemie pediatrique(clinique)
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18 20 25 30 35 37 40 45100
1,000
2,000
2,500
3,000
4,000
5,000
6,000
Birt
hwei
ght,
gram
s
Gestational Age, weeks
66
Dans les deux graphiques, on remarque une tendance croissante de log(OR) ainsi
que des valeurs très significatives dépassant 2.00 (OR > 7.40) lorsque les seuils
de WBC sont proches de 120. Ainsi, ces derniers résultats viennent conforter l’hy-
pothèse de l’effet direct de WBC sur la résistance à l’insuline. Globalement, ces
résultats semblent indiquer que la prévalence élevée de complications cardiomé-
taboliques ne serait pas exclusivement due au traitement de la LALe, mais serait
également due à la maladie elle-même.
• •
•
• 2
1
CS Y I
WBC
TXT
3
Figure 2.1 Liens causaux potentiels entre les niveaux de doses de corticostéroïdes
(CS), d’autres agents chimiothérapeutiques (TXT), les WBC et la résistance à
l’insuline (Y I). Fixer TXT et CS permet d’isoler et estimer la force du lien 1.
Questions liees a la modelisation et l’interpretation:
Est-ce qu’un traitement (exposition) est associe a une variablereponse ?
Quelles sont les conditions pour obtenir une interpretation causale?
Le modele d’analyse est-il correct ou comment l’ameliorer ?
G Lefebvre & JF Coeurjolly STATQAM 6 / 9
2. Statistique genetique
Questions liees a la modelisation et la methodologie:
Comment incorporer des genealogies dans les analyses de partagede variants rares?
Comment developper des tests d’association genetique pour destraits quantitatifs multivaries?
Modelisation de la dependance familialeMecanismes de selection d’echantillon
G Lefebvre & JF Coeurjolly STATQAM 7 / 9
3. Statistique spatiale et grande dimension
Exemple de jeu de donnees:
> 300,000 positions d’arbres,> 300 especes ,
⇡ 100 covariables spatiales: eg.altitude, nature des sols,. . .
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Questions liees a des problemes de grande dimension:
Comment selectionner les facteurs environnementaux,physico-chimiques les plus influents expliquant la repartition?
Comment modeliser parcimonieusement la dependance entre les> 300 especes d’arbres?
Comment estimer par methode Monte-CarloRRd
f (u)du?
G Lefebvre & JF Coeurjolly STATQAM 8 / 9
STATQAM a court terme
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STATQAMrecrute
Bourses de stage de1er cycle; [ete 2019 -en cours]
Bourses derecrutement a lamaıtrise; [automne2019 - en cours]
Nos professeursrecrutentcontinuellement audoctorat etpost-doctorat.
G Lefebvre & JF Coeurjolly STATQAM 9 / 9
