Rafsos

Grb2

PTB

Ras

MAPK

Ubiquilin

Mint - 2 Mint - 3Mint - 1

Fe65

AICD

C

PS1 / PS2

Pen-2Aph - 1α1Aph - 1α2Aph - 1β

cleavageactivatesγ - secretase

γ - secretase

α - secretase

β - secretase

ADAM10ADAM17

BACE1

BACE2

- 40- 42- 49

CLAC-P

Protease α2M

Aβ

Aβ Aβ

AβAβ

Aβ

Protease IDE

Protease NEP

Protease PLG

N

APP

NCT

OLIGOMERIZATION DEGRADATIONCLEARANCE / EXPORT

CYTOPLASM

Aβ

P3ApoE

ApoE

SH2

Shc

Aβ

Aβ

Aβ

Aβ Aβ Aβ

Aβ

Aβ

YENPTY

LRP

NOTCH

ErbB4

CD44

P75N

T

R

γ secretase

E-CADHERIN

Alzheimer’s Disease:Amyloid Precursor Protein (APP) processing