Octreotide Gallstones and altered glucose tolerance: incidence study

Ten patients with acromegaly received SC octreotide lOOllg tid . increased monthly by 300llg to a maximum of 1500 Ilg which was continued for 7 months.

Of 3 patients with normal glucose tolerance before therapy, 1 was uneffected , 1 developed impaired tolerance and 1 became a diabetic. Of 4 patients with impaired glucose tolerance prior to octreollde therapy, 2 remained unchanged , 1 developed diabetes and the other patient returned to normal glucose tolerance levels. Gallstones developed in 3 patients within 1 year .

'The high incidence of new gal/ stones found in our prospective study is a cause for concern. '

Markby DP Lyme disease facial palsy differentiation from Bells palsy British Medical Journal 299 604·605 2 Sep 1989 "