Octreotide

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Octreotide Gallstones and altered glucose tolerance: incidence study Ten patients with acromegaly received SC octreotide lOOllg tid. increased monthly by 300llg to a maxi mum of 1500 Ilg which was continued for 7 months. Of 3 patients with normal glucose tolerance before therapy, 1 was uneffected, 1developed impaired tolerance and 1 became a diabetic. Of 4 patients with impaired glucose tolerance prior to octreollde therapy, 2 remained unchanged, 1 developed diabetes and the other patient returned to normal glucose tolerance levels. Gallstones developed in 3 patients within 1 year. 'The high incidence of new gal/ stones found in our prospective study is a cause for concern. ' Markby DP Lyme disease facial palsy differentiation from Bells palsy British Medical Journal 299 604 ·605 2 Sep 1989 "

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Page 1: Octreotide

Octreotide Gallstones and altered glucose tolerance: incidence study

Ten patients with acromegaly received SC octreotide lOOllg tid . increased monthly by 300llg to a maximum of 1500 Ilg which was continued for 7 months.

Of 3 patients with normal glucose tolerance before therapy, 1 was uneffected , 1 developed impaired tolerance and 1 became a diabetic. Of 4 patients with impaired glucose tolerance prior to octreollde therapy, 2 remained unchanged , 1 developed diabetes and the other patient returned to normal glucose tolerance levels. Gallstones developed in 3 patients within 1 year .

'The high incidence of new gal/ stones found in our prospective study is a cause for concern. '

Markby DP Lyme disease facial palsy differentiation from Bells palsy British Medical Journal 299 604·605 2 Sep 1989 "