Onderzoeksgroep Statistiek A. Identiteit van de deelnemende onderzoekers

Veraverbeke Noël, Janssen Paul, Aerts Marc, Molenberghs Geert, Callaert Herman, Lemeire Frans, Lindsey Jim, Buyse Marc, Sylvester Richard, Goetghebeur Els, Verbeke Geert, van der Heijden Peter, Weyler Joost, Augustyns Ilse, Michiels Bart, Van Keilegom Ingrid, Declerck Lieven, Geys Helena, Claeskens Gerda, Tans Heidi, Bruckers Liesbeth, Harrington David, Hart Jeff, Gefeller Olaf, Cadarso-Suarez Carmen, Lambert Philippe, Curran Desmond, Thijs Herbert.

B. Titels van de onderzoeksprojecten

a. Mathematische Statistiek en Stochastische Modellen b. Medische Statistiek

C. Beschrijving van de ontwikkelde onderzoeksactiviteiten per project

- Conditional Kaplan-Meier estimator in fixed design regression model (IVK, NV).

- Bootstrap voor gecensureerde data (IVK, NV). - Koziol-Green model (NV, Cadarso (Santiago de Compostela)). - Simulation study for censored regression data (IVK, Akritas (Penn State), NV). - Relative density estimation with censored data (Cao (La Coruna), PJ, NV). - Estimation of the probability of censoring (Cao (La Coruna), PJ, NV). - Power properties in small experiments (Duchateau (Nairobi), PJ). - Mixed models in veterinary research (Duchateau (Nairobi), PJ). - Goodness-of-fit tests and censored data (Hart (Texas A&M), PJ, HTans, NV). - Relative density estimation and polarization measures (Handcock (Penn State),

PJ). - Bootstrapping local polynomial estimators in likelihood-based models (MA,

GC). - Bootstrapping pseudolikelihood models for clustered binary dat (MA, GC). - Bootstrap tests for mispecified clustered binary data models (MA, GC). - Testing the fit of a parametric function in likelihood-based model (MA, GC, Hart

(Texas A&M)) - Orthogonal series estimators in multiparameter models (MA, GC, Hart (Texas

A&M)) - The impact of the 3-way en 4-way association parameter in the Bahadur model

for clustered binary data (MA, LD, GM).

- Quantitative risk assessment with clustered binary data (MA, LD, GM, Ryan (Harvard))

- Robust benchmark dose estimation (MA, GC, GM). - Pseudo-likelihood inference for clustered binary data (HG, GM, Ryan

(Harvard)). - Inference for pseudo-likelihood models (HG, GM). - Random and non-random selection and pattern mixture non-response mechanism

(BM, GM). - Effect of misspecification on dose effect and on ‘virtually safe dose’ (LD). - Behavior of the likelihood ratio statistic in a Bahadur model (LD). - Dose-response models (LD). - Sensitivity analysis (GM, EG, HThijs). - Causal inference for non-compliance in clinical trials (EG). - Analysis of missing and coarsened data (EG, GM, GV). - Generalized linear models, categorical data, repeated measurements, stochastic

processes (JL) - Direct likelihood inference, exponential family, model selection (JL).

D. Mededelingen van resultaten van het onderzoekswerk 1. Doctoraats- en aggregaatsthesissen

11. In de onderzoeksgroep behaalde doctoraten

23 mei 1997 : Ilse Augustyns : Local polynomial smoothing of sparse multinomial data. (promotor : Paul Janssen; copromotor : Marc Aerts)

13. Lidmaatschappen van jury's van buitenlandse doctoraten

Jim Lindsey : external examiner voor Ph.D. thesis van Ronnie Lee, University of Waterloo, Canada, december 1997.

14. Lidmaatschappen van jury's van binnenlandse doctoraten

Els Goetghebeur: lid van examencommissie voor doctoraat van Stefan Rombouts (Universiteit Gent), promotor Chris Heyde, mei 1997.

2. Wetenschappelijke publicaties

Internationale wetenschappelijke publicaties

20. Gepubliceerde artikels in internationale tijdschriften (opgenomen in de JCR of in een door de Onderzoeksraad erkende alternatieve tijdschriftenlijst).

Van Keilegom, I. and Veraverbeke, N. (1997). Estimation and bootstrap with censored data in fixed design nonparametric regression. Ann. Inst. Statist. Math., 49, 467-491. Veraverbeke, N. (1997). Bootstrapping in survival analysis. South African Statistical J., 31, 217-258. Aerts, M., Augustyns, I. and Janssen, P. (1997). Sparse consistency and smoothing for multinomial data. Statist. Prob. Letters, 33, 41-48. Janssen, P. (1997). Bootstrapping U-statistics. South African Statistical J., 31, 185-216. Aerts, M., Augustyns, I. and Janssen, P. (1997). Local polynomial estimation of contingency table cell probabilities. Statistics, 30, 127-148. Aerts, M. and Claeskens, G. (1997). Local polynomial estimation in multiparameter likelihood models. Journal of the American Statistical Association, 92, 1536-1545. Molenberghs, G. and Goetghebeur, E. (1997). Simple fitting algorithms for incomplete categorical data. Journal of the Royal Statistical Society, Series B, 59, 401-414. Molenberghs, G. and Lesaffre, E. (1997). Non-linear integral equations to construct bivariate densities with given marginals and dependence function. Statistica Sinica, 7, 713-738. Molenberghs, G., Kenward, M.G., and Lesaffre, E. (1997). The analysis of longitudinal ordinal data with non-random dropout. Biometrika, 84, 33-44. Wuyts, F.L., Van de Heyning, P.H., Van Spaendonck, M.P. and Molenberghs, G. (1997). A review of electrocochleography : instrumentation settings and meta-analysis of criteria for diagnosis of endolymphatic hydrops. Acta Otolaryngologica (Suppl.), 526, 14-20. Lipsitz, S.R., Fitzmaurice, G.M., Molenberghs, G. and Zhao, L.P. (1997). Quantile regression methods for longitudinal data with drop-outs. Applied Statistics, 46, 463-476. Walravens, M.J.F., Vanherrewegen, H., Lacquet, F., Gedefridis, G., Korevits, G., Stevens, E., Marien, G. and Molenberghs, G. (1997). Counterimmunoelectrophoresis with serum prediffusion : an improved method for the detection and identification of antibodies against extractable nuclear and cytoplasmic antigens. Journal of Immunological Methods, 201, 89-98.

Molenberghs, G. (1997). Discussion of Copas, J.B. and Li, H.G. : Inference for non-random samples. Journal of the Royal Statistical Society, Series B, 59, 88-89. Molenberghs, G. (1997). Discussion of Diggle, P. and Al Wasel, I. : Spectrial analysis of replicated biomedical time series. Applied Statistics, 46, 68. Molenberghs, G. (1997). Discussion of Fitzmaurice, G.M., Heath, A.F. and Cox, D.R. : Detecting overdispersion in large-scale surveys : application to a study of education and social class in Britain. Applied Statistics, 46, 428-429. Molenberghs, G., Declerck, L. and Aerts, M. (1997). Misspecifying the likelihood for clustered binary data. Computational Statistics and Data Analysis, 20, 327-349. Lindsey, J.K. (1997). Stopping rules and the likelihood function. Journal of Statistical Planning and Inference, 59, 167-177. Lindsey, J.K. (1997). Parametric multiplicative intensities models fitted to bus motor failure data. Journal of the Royal Statistical Society, C46, 245-252. Lindsey, J.K. (1997). Exact sample size calculation for exponential family models. Journal of the Royal Statistical Society, D46, 231-237. Lindsey, J.K. and Jones, B. (1997). Treatment-patient interactions for diagnostics of crossover trials. Statistics in Medicine, 16, 1955-1964. Lindsey, J.K. (1997) Review of Statistical Applications Using Fuzzy Sets by Manton, K.G., Woodbury, M.A. and Tolley, H.D.. Statistics in Medicine, 16, 1789-1790. Lindsey, J.K., Jones, B. and Ebutt, A.F. (1997). Simple models for repeated ordinal responses, with an application to seasonal rhinitis clinical trial. Statistics in Medicine, 16, 2873-2882. Struys, M., Versichelen, L., Thas, O., Herregods, L. and Rolly, G. (1997). Comparison of computer-controlled administration of propofol with two manually controlled infusion techniques. Anaesthesia, 52, 44-50. Vrijens, B. and Goetghebeur, E. (1997). Comparing compliance patterns between randomized treatments. Controlled Clin. Trials, 18, 187-203. Goetghebeur, E. and Lapp, K. (1997). The effect of treatment compliance in a placebo-controlled trial : regression with unpaired data. Applied Statistics, 46, 351-364.

Goetghebeur, E. and Lapp, K. (1997). Contribution to the discussion of the paper Inference from non-random samples by Copas and Li. Journal of the Royal Statistical Society, Series B, 59, 87-88. Verbeke, G. and Lesaffre, E. (1997). The effect of misspecifying the random effects distribution in linear mixed models for longitudinal data. Computational Statistics and Data Analysis, 23, 541-556. Brant, L.J. and Verbeke, G. (1997). Describing the natural heterogeneity of aging using multilevel regression models. International Journal of Sports Medicine, 18, S225-S231. Boonen, S., Nicholson, P., Lowet, G., Cheng, X., Verbeke, G., Lesaffre, E., Aerssens, J. and Dequeker, J. (1997). Determinants of age-associated changes in os calcis ultrasonic indices in elderly women. Age and Ageing, 26, 139-146. Boonen, S., Broos, P., Verbeke, G., Aerssens, J., Van Herck, E., Jans, I., Dequeker, J. and Bouillon, R. (1997). Calciotropic hormones and markers of bone remodeling in age-related (type II) femoral neck osteoporosis. Journal of Gerontology : Medical Sciences, 52, 286-293. Willems, G., Carels, C. and Verbeke, G. (1997). In vitro peel/shear bond strength of orthodontic adhesives. Journal of Dentistry, 25, 263-270. Willems, G., Carels, C. and Verbeke, G. (1997). In vitro peel/shear bond strength evaluation of bracket base design. Journal of Dentistry, 25, 271-278. Boonen, S., Aerssens, J., Dequeker, J., Nicholson, P., Cheng, X.G., Lowet, G., Verbeke, G. and Bouillon, R. (1997). Age-associated decline in human femoral neck cortical and trabecular content of insulin-like growth factor-I : Potential implications for age-related (type II) osteoporotic fracture occurrence. Calcified Tissue International, 61, 173-178. Van Erum, R., Mulier, M., Carels, C., Verbeke, G. and de Zegher, F. (1997). Craniofacial growth in short children born small for gestational age : Effect of growth hormone treatment. Journal of Dental Research, 76, 1579-1586. Peeters, M., Geypens, B., Claus, D., Nevens, H., Ghoos, Y., Verbeke, G., Baert, F., Vermeire, S., Vlietinck, R. and Rutgeerts, P. (1997). Clustering of increased small intestinal permeability in families with Crohn’s disease. Gastroenterology, 113, 802-807. van der Heijden, P.G.M., Dessens, J. and Jansen, W. (1997). Book review of Statistical models for ordinal variables. Statistics in Medicine, 16, 483-484.

Peto, R., Collins, R., Sackett, D., Darbyshire, J., Babiker, A., Buyse, M., Stewart, H., Baum, M., Goldhirsch, A., Bonadonna, G., Valagussa, P., Rutqvist, L., Elbourne, D., Altman, D., Dalesio, O., Parmar, M., Hill, C., Clarke, M., Gray, R., Doll. R. (1997). The trials of Dr. Bernard Fisher : a European perspective on an American episode. Controlled Clin. Trials, 18, 1-13. Pastorino, U., Buyse, M., Friedel, G., Ginsberg, R.J., Girard, P., Goldstraw, P., Johnston, M., McCormack, P., Pass, H., Putman, J.B.Jr.. (1997). For the International Registry of Lung Metastases. Long-term results of lung metastasectomy: prognostic analyses based on 5, 206 cases. J. Thoracic Cardiovasc. Surg., 113, 37-49. Durand-Zaleski, I., Roche, B., Buyse, M., Carlson, R., O’Connell, M.J., Rougier, P., Chang, A.E., Sondak, V.K., Kemeny, M.M., Allen-Merch, T.G., Fagniez, P.L., Le Bourgeois J.P., Piedbois, P. for the Meta-Analysis Group in Cancer. (1997). Pharmacoeconomic implications of hepatic arterial infusion versus intravenous chemotherapy for the treatment of liver metastases of colorectal cancer origin. J. Natl. Cancer Inst., 89, 790-795. Buyse, M., Piedbois, P. (1997). Letter to the Editor : Artificial neural networks. Lancet, 350, 1175. Buyse, M. (1997). A biostatistical tribute to Ignaz Philip Semmelweis. Statistics in Medicine, 16, 2767-2772. Sylvester, R. (1997). An introduction to the statistical design of phase III cancer clinical trials. European Urology, 31 (Suppl. 1), 65-71. Friberg, S., Taube, A., Sylvester, R. and Oesterling, J.E. (1997). Analysis and presentation. Urology, 49 (4A), 54-65. Bartelink, H., Rubens, R.D., Van der Schueren, E., Sylvester, R. (1997). Hormonal theorapy prolongs survival in irradiated locally advanced breast cancer : a European Organization for Research and Treatment of Cancer randomized phase III trial. J. Clin. Oncol., 15, 207-215. Horwich, A., Sleijfer, D.T., Fossa, S.D., Kaye, S.B., Oliver, R.T.D., Cullen, M.H., Mead, G.M., de Wit, R., de Mulder, P.H.M., Dearnaley, D.P., Cook, P.A., Sylvester, R.J. and Stenning, S.P. (1997). Randomized trial of bleomycin, etoposide, and cisplatin compared with bleomycin, etoposide, and carboplatin in good-prognosis metastatic nonseminomatous germ cell cancer : A multi-institutional Medical Research Council / European Organization for Research and Treatment of Cancer Trial. J. Clin. Oncol., 15, 1844-1852. de Wit, R., Stoter, G., Kaye, S.B., Steijffer, D.Th. , Jones, W.G., ten Bokkel Huinink, W.W., Rea, L.A., Collette, L., Sylvester, R. (1997). Importance of

Bleomycin in combination chemotherapy for good prognosis testicular non-seminoma; A randomized study of the EORTC Genitourinary Tract Cancer Cooperative Group. J. Clin. Oncol., 15, 1837-1843. de Wit, R., Sylvester, R., Tsitsa, C., de Mulder, P.M.H., Sleyfer, D.T., ten Bokkel-Huinink, W.W., Kaye, S.B., van Oosterom, A.T., Boven, E. and Stoter, G. (1997). Tumour marker concentration at the start of chemotherapy is a stronger predictor of treatment failure than marker half-life : a study in patients with disseminated non-seminatomous testicular cancer. Britisch Journal of Cancer, 75, 432-435. Vegt, P., Van der Meijden, A., Sylvester, R., Brausi, M., Holtl, W., De Balincourt, C. (1997). Does Isoniazed reduce side effects of intravesical Bacillus Calmette-Guerin therapy in superficial bladder cancer ? Interim results of EORTC protocol 30911. Journal of Urology, 157, 1246-1249. Kurth, K., Tunn, U., Ay, R., Schroder, F., Pavone-Macaluso, M., Debruyne, F., Ten Kate, F., De Pauw, M., Sylvester, R. (1997). Adjuvant chemotherapy for superficial transitional cell bladder carcinoma : long term results of a European Organization for Research and Treatment of Cancer randomized trial comparing Doxorubicin, Ethoglucid and transurethral resection alone. Journal of Urology, 158, 378-384. Van Hal, G., Weyler, J., Matthyssen, M. (1997). How susceptible is the Antwerp female population to mammographic screening ? European Journal of Public Health, 7, 77-81.

Singh, K.S., Segers, K., Rodeck, U., Backhovens, H., Bogers, J., Weyler, J., Van Broeckhoven, C., Van Marck, E. (1997). WT1 mutation in maligant mesothelioma and WT1 immunoreactivity in relation to p53 and growth factor receptor expression, cell-type transition, and prognosis. J. Pathol., 181, 67-74. Tjalma, W., Weyler, J., Goovaerts, G., De Pooter, C., Van Marck, E., Van Dam, P. (1997). Prognostic value of bol-2 expression in patients with operable carcinoma of the uterine cervix. J. Clin. Pathol., 50, 33-36. Wieringa, M., Weyler, J., Van Bastelaer, F., Nelen, V., Van Sprundel, M., Vermeire, P. (1997). Higher asthma occurrence in urban than suburban area : Role of house dust mite skin allergy. Eur. Resp. J., 10, 1460-1466. Singh, K.S., Vermeulen, P., Weyler, J., Segers, K., Weyn, B., Van Daele, A., Dirix, L., Van Oosterom A., Van Marck, E. (1997). Evaluation of tumor angiogenesis as a prognostic marker in malignant mesothelioma. J. Pathol., 182, 211-216. Nitti, D., Wils, J., Sahmoud, T., Curran, D., Couvreur, M.L., Lise, M., and Rauschecher, H. (1997). Cuimaraes dos Santos, J., Stremmel, W., Roelofsen, F. Final results of a phase III clinical trial on adjuvant intraportal infusion with heparin and 5-FU in resectable colon cancer (EORTC GITCCG 1983-1987). Eur. J. Cancer, 33, 1209-1215. van der Burg, M., Bolis, G., Bakker, P.J.M., Curran, D., Sahmoud, T., Vermorken, J.B. (1997). Phase II study of weekly 4’-epidoxorubicin in patients with metastatic adenocarcinoma of the cervix : An EORTC Gynecological Cancer Cooperative Group Study. Eur. J. Cancer, 33, 1513-1515. Curran, D., Fossa, S., Aaronson, N., Kiebert, G., Keupens, F. and Hall, R. (1997). Baseline quality of life of patients with advanced prostate cancer. Eur. J. Cancer, 33, 1809-1814.

Overige wetenschappelijke publicaties 25. Overige artikels

Van Keilegom, I. and Veraverbeke, N. (1997). Weak convergence of the bootstrapped conditional Kaplan-Meier process and its quantile process. Commun. Statist. - Theory Meth., 26, 853-869. Aerts, M., Augustyns, I. and Janssen, P. (1997). Smoothing sparse multinomial data using local polynomial fitting. J. Nonpar. Statist., 8, 127-147.

Janssen, P. (1997). Review of ‘Statistical Theory and Computational Aspects of Smoothing’ (Authors : Härdle, W. and Schimek, M.G.). Computational Statistics, 12, 423-424. Aerts, M., Declerck, L. and Molenberghs, G. (1997). Likelihood misspecification and safe dose determination for clustered binary data. Environmetrics, 8, 613-627. Michiels, B. and Molenberghs, G. (1997). Protective estimation of longitudinal categorical data with nonrandom dropout. Commun. Statist. - Theory and Meth., 26, 65-94. Geys, H., Molenberghs, G. and Ryan, L.M. (1997). Pseudo-likelihood inference for clustered binary data. Commun. Statist. - Theory Meth., 26, 2743-2767. Lindsey, J.K. (1997). Macros for fitting counting processes. GLIM Newsletter, 27, 14-18. Lambert, P. (1997). Predictions in overdispersed series of counts using an approximate predictive likelihood. Journal of Forecasting, 16, 195-207. Buyse, M., Piedbois, P. (1997). La randomisation dans les essais cliniques. Revue de Presse d’Oncologie Clinique, 6, 1.

26. Artikels in proceedings

Augustyns, I. and Janssen, P. (1997). Smoothing in action. Proc. 5th Scientific Conference of the East, Central and Southern Network of the Int. Biometric Society, 1-11 (eds. Duchateau and Mwambi). (ISBN 92-9146-026-5) Molenberghs, G. and Kenward, M.G. (1997). Calculating the appropriate information matrix for log-linear models when data are missing at random, in : Lecture Notes in Statistics 122, Proceedings of the Nantucket conference on Modelling Longitudinal and Spatially Correlated Data : Methods, Applications, and Future Directions, Gregoire, T., Brillinger, D.R., Diggle, P.J., Rusek-Cohen, E., Warren, W.G., Wolfinger, R.D. (eds), Springer-Verlag, New York, 331-337. Geys, H., Molenberghs, G. and Williams, P. (1997). Analysis of clustered binary data with covariates specific to each observation, in : Good Statistical Practice, Proceedings of the 12th International Workshop on Statistical Modelling, Minder, C.E., Friedl, H. (eds), Schriftenreihe der Österreichischen Statistischen Gesellschaft, Band 5, Wien, ISBN 3-7007-0046-6.

Declerck, L., Molenberghs, G. and Aerts, M. (1997). The influence of simplifying the Bahadur model on the likelihood ratio statistic, in : Good Statistical Practice, Proceedings of the 12th International Workshop on Statistical Modelling, Minder, C.E., Friedl, H. (eds), Schriftenreihe der Österreichischen Statistischen Gesellschaft, Band 5, Wien, 130-134, ISBN 3-7007-0046-6. Verbeke, G. and Lesaffre, E. (1997). The linear mixed model. A critical investigation in the context of longitudinal data. In : Proceedings of the Nantucket conference on Modelling Longitudinal and Spatially Correlated Data : Methods, Applications, and Future Directions, Gregoire, T. (ed.). Lecture Notes in Statistics, 122, Springer-Verlag, New York, 89-99.

Brant, L.J. and Verbeke, G. (1997). Modelling longitudinal studies of aging, Proceedings of the 12th International Workshop on Statistical Modelling, Biel/Bienne, Switserland, July 7 to 11, 19-30 Schriftenreihe der Österreichischen Statistischen Gesellschaft, Band 5, Wien, ISBN 3-7007-0046-6. Piedbois, P., Buyse, M., Pignon, J.P. (1997). Critical issues in colorectal cancer trial design. In : Management of Colorectal Cancer (H. Bleiberg, P. Rougier, H.J. Wilke, eds.) : 375-386, Martin Dunitz Publishers, London. van der Heijden, P.G.M., ‘t Hart, H. and Dessens, J. (1997). A parametric bootstrap procedure to perform statistical tests in latent class analysis. In : J. Rost and R. Langeheine (eds.). Applications of latent trait and latent class models in the social sciences. New York : Waxman Muenster, 190-202. van der Ark, L.A., van der Heijden, P.G.M. (1997). Graphical display of latent budget analysis and latent class analysis, with special reference to correspondence analysis. In : M. Greenacre and J. Blasius (Eds.), Visualization of categorical data. San Diego : Academic Press.

28. Uitgaven van wetenschappelijke boeken

Verbeke, G. and Molenberghs, G. (1997). Linear Mixed Models in Practice : A SAS Oriented Approach, Lecture Notes in Statistics 126. New York : Springer-Verlag. Lindsey, J.K. (1997). Applying Generalized Linear Models. New York : Springer-Verlag.

3. Congressen en voordrachten

32. Voordrachten op internationale wetenschappelijke congressen

- Noël Veraverbeke

18-26 augustus 1997 : 51st Session of the International Statistical Institute, Istanbul, Turkije. Hazard rate estimation in regression with censored data.

- Paul Janssen

september 1997 : 5th Scientific conference of the East, Central and Southern Africa Network of the International Biometric Society, Mombassa, Kenya. Smoothing in action (invited lecture).

- Marc Aerts

31 augustus - 4 september 1997 : ISI Satellite meeting, Mathematical statistics and its applications in biosciences, Rostock, Duitsland. Parametric bootstrap for pseudolikelihood models.

- Geert Molenberghs . 21-22 mei 1997 : Understanding, applying and not misusing the

mathematical and statistical techniques used in clinial trials. Henri Stewart Conference Studies, Brussels. Criteria for the validation of surrogate endpoints in randomized experiments. (22 mei 1997) (with M. Buyse).

. 18-20 juni 1997 : Nordic regional meeting of the International Biometric Society, Aas, Norway. Marginal models for multivariate and longitudinal categorical data (18 juni 1997).

. 7-10 juli 1997 : Joint meeting of the Society for Clinical Trials and the International Society for Clinical Biostatistics, Boston, U.S.A. The validation of surrogate endpoints in randomized clinical trials (7 juli 1997) (with M. Buyse).

. 22-25 juli 1997 : Burning issues in medical statistics, De Montfort University, Leicester, U.K. Non-random missingness in categorial data : strengths and limitations (25 juli 1997) (with E. Goetghebeur and S.R. Lipsitz).

- Ingrid Van Keilegom

31 augustus - 4 september 1997 : ISI Satellite meeting, Mathematical statistics and its applications in biosciences, Rostock, Duitsland. Estimation of the tail of the conditional distribution in censored regression models.

- Helena Geys

. 23-26 maart 1997 : Spring Meeting of the International Biometric Society, Eastern North American region, Memphis, U.S.A. Inference for pseudo-likelihood methods (26 maart 1997).

. 7-11 juli 1997 : 12th International workshop on statistical modelling, Biel, Zwitserland. Analysis of clustered binary data with covariates specific to each observation. Lieven Declerck

. 24-26 maart 1997 : Spring Meeting of the International Biometric Society, Eastern North American region, Memphis, U.S.A. The influence of simplifying the Bahadur model on the likelihood ratio statistic.

- Gerda Claeskens

. 18-22 augustus 1997 : 10th European Young Statisticians Meeting, Warschau, Polen.

Parametric bootstrap for pseudolikelihood models (18 augustus 1997). . 31 augustus - 4 september 1997 : ISI Satellite meeting, Mathematical

statistics and its applications in biosciences, Rostock , Duitsland. Local ploynomial estimation in multiparameter likelihood models (3

september 1997).

- Jim Lindsey

. april 1997 : Statistical Methodology in Clinical Research and Development, Nice, Frankrijk. On the appropriateness of marginal models for repeated measurements in clinical trials. (invited lecture)

. 22-25 juli 1997 : Burning issues in medical statistics, De Montfort University, Leicester, U.K. A review of some extensions to generalized linear models. (invited lecture)

. august 1997 : American Statistical Association, Anaheim, U.S.A. On the appropriateness of marginal models for repeated measurements in clinical trials. (invited lecture)

- Els Goetghebeur

. 21-22 mei 1997 : Understanding, applying and not misusing the mathematical and statistical techniques used in clinical trials. Henri Stewart Conference Studies, Brussels. The role of intention to treat analysis in clinical trials. (22 mei 1997)

. 23-26 maart 1997 : Spring Meeting of the International Biometric Society, Eastern North American region, Memphis, U.S.A. On the predictability of noncompliance patterns.

. 22-25 juli 1997 : Burning issues in medical statistics, De Montfort University, Leicester, U.K. Structural models for the analysis of important questions in clinical trials : theory and practice beyond intention-to-treat (invited lecture).

. 26-29 juli 1997 : Inferential problems in the analysis of treatment effects. Workshop. Santa Fe, U.S.A. A note on bias identifiability and power when using (structural) mean models to identify the expected effect of actual treatment in a placebo-controlled trial. (invited lecture)

. 31 augustus - 4 september 1997 : ISI Satellite meeting, Mathematical statistics and its applications in biosciences, Rostock, Germany. Estimating the effect of observed exposure in experimental settings : opportunity, limitations and risk (invited lecture).

- Geert Verbeke

7-11 juli 1997 : 12th International workshop on statistical modelling, Biel, Zwitserland. The impact of dropout on the efficiency of longitudinal experiments.

- Peter van der Heijden

. 15-18 juli 1997 : 10th European meeting of the psychometric society, Santiago de Compostela, Spain. Geometry and identifiability in the latent budget model.

. 21 november 1997 : American Society of Criminology, San Diego, U.S.A. Does the randomized response method invoke sufficient trust to ensure less evasive answers ?

- Marc Buyse

. 3-5 juni 1997 : Euro Cancer Meeting, Paris, France. Traitements adjuvants des Cancers colorectaux (invited paper). How to assess intergroup data in early stage breast cancer (invited paper).

. 8-12 juni 1997 : Bio’97 International Biotechnology Meeting, Houston, Texas. Technological and methodological issues in clinical development (invited paper).

. 21 juni 1997 : Congres on Medical Management of Colorectal Cancer, Cannes, France. Relationship between response and survival.

. 6-9 juli 1997 : Joint meeting of the Society of Clinical Trials and the International Society for Clinical Biostatistics, Boston. The role of biostatistics in the prevention, detection and treatment of fraud in clinical research (invited paper).

. 24 september 1997 : Henry Stewart Conference, Washington DC. Why meta-analyses should be based on individual patient data (invited paper).

- Richard Sylvester

. 12-17 april 1997 : AUA 92nd Annual Meeting, New Orleans, U.S.A. Invited lecture at the course : Principles of Research Study Design and Statistics for the Urologist.

. 17-20 mei 1997 : 33rd Annual Meeting of the American Society of Clinical Oncology, Denver, U.S.A.

. Serum alpha-fetoprotein surges after the initiation of chemotherapy have a strong adverse prognostic significance in non-seminomatous testicular cancer.

. 21-22 mei 1997 : Understanding, applying and not misusing the mathematical and statistical techniques used in clinical trials. Henri Stewart Conference Studies, Brussels. Invited lecture, 21 mei 1997.

. 7-10 juli 1997 : 2nd Joint meeting of the Society for Clinial Trials and the International Society for Clinical Biostatistics, Boston, U.S.A. Surrogate endpoints for the prophylactic treatment of TaT1 bladder cancer : a combined analysis of EORTC and MRC randomized trials.

33. Voordrachten in het buitenland op uitnodiging van instellingen of

organisaties

- Paul Janssen . 16 september 1997 : Department of Mathematics, University of Nairobi,

Kenya. Bootstrapping : a review.

. 17-19 september 1997 : Workshop linear mixed models in veterinary reseach International Livestock Research Institute, Nairobi, Kenya. 3 lectures : (1) Matrix algebra useful for statistics, (2) Fixed effect models, (3) An example-based tour in linear mixed models.

- Geert Molenberghs

. 4 juni 1997 : Seminar. Sonderforschungsbereich 386, Institute of Statistics, University of Munich, Germany. Likelihood based methods for multivariate and longitudinal categorical data, with dropout.

. 9 december 1997 : Department of Biostatistics, University of Michigan, Ann Arbor, U.S.A. Sensitivity analysis for non-random dropout : a local influence approach.

. 17 december 1997 : Department of Statistics, Harvard University, U.S.A. Sensitivity analysis for non-random dropout : a local influence approach.

- Ingrid Van Keilegom . 4 april 1997 : Department of Statistics, University of North Carolina, Chapel

Hill, U.S.A. Estimation in censored regression models via transfer of tail information.

. 11 april 1997 : Department of Statistics, University of Pennsylvania, Philadelphia, U.S.A. Estimation in censored regression models via transfer a tail information.

. 17 april 1997 : Department of Statistics, Pennsylvania State University, University Park, U.S.A. Transferring tail information for estimation in censored regression models.

. 4 november 1997 : Department of Statistics, Ruhr-Universität, Bochum, Germany. Estimation of the conditional distribution in censored heteroscedastic regression models with applications.

- Jim Lindsey

. december 1997 : Freie Universität, Berlin, Germany. Generalized nonlinear models for pharmacokinetic data.

. december 1997, University of Waterloo, Canada. A general family of distributions for longitudinal dependence with special reference to event histories.

- Els Goetghebeur

. 4 augustus 1997. Stanford University. The structural mean model for analyzing the effect of compliance in placebo-controlled trials : an efficient and robust competitor.

. 3 november 1997 : Universiteit Stockholm, Zweden. Estimating the effect of observed and experimental exposure : tales of opportunity, limitations and risks.

- Peter van der Heijden

. 4 juni 1997 : Freie Universität Berlin, Department Humanmedizin. Estimating the number of illegal immigrants in the Netherlands.

- Marc Buyse

. 3 februari 1997 : Heidelberger Kolloquium Medizinische Biometrie, Informatik und Epidemiologie, Heidelberg. A personal view on the comparison between meta-analyses based on the literature and on individual patient data.

. 7 april 1997 : Dutch Oncology Society, Noordwijkerhout, The Netherlands. Statistics in clinical research.

. 2-3 juli 1997 : Henry Stewart Conference “Understanding, applying and not misusing the mathematical and statistical techniques used in clinical trials”, London, U.K. Randomization, minimization, stratification.

. 23 september 1997 : National Institutes of Health, Bethesda, Maryland.

Criteria for the statistical validation of surrogate endpoints in randomized experiments.

. 26 september 1997 : National Institutes of Health, Bethesda, Maryland. EuroCRIS (European Clinical Research Information System) : a database of clinical trial protocols in AIDS.

. 20 oktober 1997 : Novartis, Basel, Switzerland. The role of randomization in early phase clinical trials.

. 30 oktober 1997 : Rhône Poulenc Rorer, Anthony, France. Analyse des données de survie.

. 18 november 1997 : University of Barcelona, Barcelona, Spain. Interim analyses, stopping rules, and data monitoring committees.

. 25 november 1997 : NeXstar, Boulder, Colorado. Methodology of clinical trials in age-related macular degeneration.

. 4-6 december 1997 : European School of Oncology, Marne-la-Vallée, France. Les essais thérapeutiques intéressant les sujets âgés.

- Desmond Curran

. februari-maart 1997 : Tata Memorial Hospital and UICC, Bombay, India. Design, organisation and conduct of clinical trials. Research methods in cancer : clinical trials, epidemiology & audit.

. Analysis of quality of life parameters. Research methods in cancer : clinical trials, epidemiology & audit.

. Analysis of clinical trials data. Research methods in cancer : clinical trials, epidemiology & audit.

- Richard Sylvester

. 8-9 september 1997 : Biomed Cancer Conference, Munich, Germany. Establishment of a meta-analysis coordination unit.

. 11 oktober 1997 : EORTC GU Group Meeting, Lisbon, Portugal. Informed consent : statistical issues.

. 25 november 1997 : Institut Gustave Roussy, Villejuif, France. Superficial bladder cancer : a combined analysis of EORTC and MRC randomized trials.

34. Presentatie van posters op internationale wetenschappelijke congressen

- Marc Aerts en Gerda Claeskens

19-21 februari 1997 : Workshop ‘The art of nonparametric statistics : methodologies and applications’, Université catholique de Louvain, Louvain-la-Neuve. Local polynomial estimation in multiparameter likelihood models. (21 februari 1997)

- Ingrid van Keilegom

19-21 februari 1997 : Workshop ‘The art of nonparametric statistics : methodologies and applications’, Université catholique de Louvain, Louvain-la-Neuve. Transfer of tail information for censored regression models.

- Bart Michiels

6-10 juli 1997 : Second joint meeting of the Society for Clinical Trials and the International Society for Clinical Biostatistics, Boston, U.S.A. Pseudo-likelihood methods for general missing data mechanisms (8 juli 1997) (met Geert Molenberghs)

- Els Goetghebeur 7-10 juli 1997 : Second joint meeting of the Society for Clinical Trials and the International Society for Clinical Biostatistics, Boston, U.S.A. Analyzing compliance in clinical trials : a sensitive point. (8 juli 1997) (met Geert Molenberghs)

- Lieven Declerck

7-10 juli 1997 : 12th International workshop on statistical modelling, Biel, Zwitserland. The influence of simplifying the Bahadur model on the likelihood ratio statistic.

36. Organisatie van andere wetenschappelijke activiteiten

- Seminars in Statistics, LUC.

Meer dan 20 lezingen in 1997 (organisatie : Noël Veraverbeke)

- 29 september 1997 : Symposium ‘Don’t miss it ! Statistical analyses acknowledging the presence of missing data’, Het Pand, Gent. (organisatie : Els Goetghebeur)

- 25 april 1997 : Studiedag ‘Registratie van Psychiatrische Gegevens’, LUC.

(organisatie : Geert Molenberghs)

4. Expert- en referee-opdrachten 41. Lidmaatschappen van editorial board van internationale tijdschriften

- Geert Molenberghs . Associate editor ‘Biometrics’ (1995 - ) . Editorial team ‘Archives of Public Health’ (1996 - ) . Associate editor ‘Applied Statistics’ (1997 - ) . Editor-elect ‘Biometric Bulletin’ (1998-2000)

- Els Goetghebeur

Lid van editorial board ‘Statistics in Medicine’ (1995 - ) - Peter van der Heijden

Lid van editorial board of Interdisciplinary Statistics Series by Chapman and Hall

- Joost Weyler

Editorial team ‘Archives of Public Health’

42. Referee-opdrachten van publicaties op aanvraag van editorial board van internationale tijdschriften

- Noël Veraverbeke

Insurance : Mathematics and Economics Journal of Statistical Planning and Inference Bernoulli Short Book Reviews (8) Mathematical Reviews (10)

- Paul Janssen

Statistica Neerlandica - Marc Aerts

Journal of the American Statistical Association - Geert Molenberghs

Journal of the Royal Statistical Society, Series B (1) Biometrics (3) Statistics in Medicine (1) Quality of Life Research (1) Communications in Statistics (1) Biometrical Journal (1) Applied Statistics (3) Springer-Verlag (book referee : 1) Applied Statistics (Associate Editor : 7) Biometrics (Associate Editor : 5)

- Ingrid Van Keilegom

Statistics and Probability Letters - Ilse Augustyns

Test - Els Goetghebeur

Journal of the American Statistical Association (1) Statistics in Medicine (5 + 1 boekbespreking) Scandinavian Journal of Statistics (1) Journal of the Royal Statistical Society, Series A (1x) Statistical Science (1x)

- Jim Lindsey Applied Statistics Astin Bulletin Belgian Journal of Operations Research, Statistics, and Computer Science (JORBEL) Belgian Journal of Zoology Biometrical Journal Biometrics European Journal of Epidemiology Journal of Statistical Planning and Inference Oxford University Press (book referee) Springer-Verlag (book referee) Statistics in Medicine (2)

- Geert Verbeke

Biometrics Psychometrika Applied Statistics

- Joost Weyler

Tropical Medicine & International Health The European Respiratory Journal International Journal of Epidemiology

44. Lidmaatschappen van scientific committee van internationale congressen

- Ingrid Van Keilegom

Lid van ‘international organising committee of the 10th European Young Statisticians Meeting’, Warsaw, Polen (18-22 augustus 1997)

- Els Goetghebeur

. Lid van het scientific committee van de ENAR Spring Meeting, Memphis, USA (23-26 maart 1997)

. Lid van het scientific committee van de Joint Meeting of the Society for Clinical Trials and the International Society for Clinical Biostatistics, Boston, USA (6-10 juli 1997)

46. Lidmaatschappen van wetenschappelijke commissies in binnen- en

buitenland

- Noël Veraverbeke . Chairman of the European Regional Committee of the Bernoulli Society

(benoemd voor de periode 1996-1998) . Lid van de wetenschappelijke Commissie Wiskunde van het FWO (benoemd

voor de periode 1993-1998)

. Lid van de Commissie voor Internationale Wetenschappelijke Contacten van het FWO (benoemd voor de periode 1994-1998)

. Lid Raad van Bestuur van de Belgische Vereniging voor Statistiek/Société Belge de Statistique (verkozen op 15 januari 1993)

. Lid Raad van Bestuur van de Société Adolphe Quetelet/Vereniging Adolphe Quetelet (verkozen op 12 maart 1993)

. Lid van de stuurgroep van de Wetenschappelijke Onderzoeksgemeenschap Wiskunde (1996-2000)

. Lid van de stuurgroep van de afdeling Wiskunde van het Vliebergh-Senciecentrum (Academisch Vormingsinstituut voor Leraren) K.U.Leuven (1995 - )

. Lid van de jury van de Vlaamse Wiskunde Olympiade. - P. Janssen

. Lid van het European Regional Committee of the Bernoulli Society (benoemd voor de periode 1994-1998)

. External Referee voor ‘Promotion and Tenure Committee, Penn State University, U.S.A.

- Geert Molenberghs

. Lid van de Raad van Bestuur van de Belgische Vereniging voor Statistiek/Société Belge de Statistique (1995- ) (treasurer)

. Lid van de Biopharmaceutical Section of the Belgian Statistical Society

. Royal Statistical Society Three Country Corner local group (president vanaf september 1997)

- Els Goetghebeur

. Committee member voor de Medical Section van de Royal Statistical Society

. Royal Statistical Society Three Country Corner local group (president tot september 1997)

. Vice president van de Quetelet Society (verkozen op 12 maart 1997) - Geert Verbeke

. Royal Statistical Society Three Country Corner local group (secretary vanaf september 1997)

5. Verwerving van extern gefinancierde onderzoeksprojecten

51. Verwerving van onderzoeksprojecten als projectleider met internationale participatie

- ‘Teaching, training and course development in statistics’

Internationaal samenwerkingsproject (1997-1998) met Zuid-Afrika LUC (promotor : Noël Veraverbeke), University of South Africa (J. Fresen), University of Natal (G. Matthews), Universiteit Oranje Vrijstaat (R. Schall),

University of Transkei (J. Simakani), Vista University, Bloemfontein (K. de Wet)

- ‘Statistical Modelling for incomplete data’

Bilateral Scientific and Technological Cooperation between Flanders and South Africa (1998-2000) LUC (promotor : Paul Janssen), K.U.Leuven (co-promotor : Jan Beirlant), Univ. Potchefstroom (promotor : J. Swanepoel), Univ. Oranje Vrijstaat (co-promotor : De Waal), Univ. South Africa, Pretoria (co-promotor : J. Fresen)

53. Verwerving van een binnenlandse (nationaal of regionaal)

onderzoeksprojecten - Geert Molenberghs

. 1998-1999. Research Project G.0002.98 F.W.O.-Vlaanderen : Sensitivity analysis for Incomplete and coarsened data.

. 1998-2001. Bijzonder Onderzoeksfonds Limburgs Universitair Centrum : Applied Statistical Research

. 1997. Instituut voor Hygiëne en Epidemiologie. Begeleiding van de Belgische Health Interview Survey.

. 1997. Instituut voor Hygiëne en Epidemiologie. Analyse van de Belgische Health Interview Survey.

. 1997. Pfizer. Analyse van een klinische studie.

. 1997. Samenwerking Psychiatrische Initiatieven Limburg. Audit “Kaart Geestelijke Gezondheidszorg”.

. 1997. Samenwerking Psychiatrische Initiatieven Limburg. Beheer en verwerking van de gegevens. In samenwerking met Prof. Dr. J. Vinck (LUC).

. 1997. Instituut voor Tropische Geneeskunde. Analyse van een epidemiologische studie.

. 1997. Algemeen Ziekenhuis Middelheim. Retinal detachment studie.

. 1997. Universitaire Instelling Antwerpen. Epidemiologie en Sociale Genees-kunde. Hepatitis B vaccination programme.

- Noël Veraverbeke

1997. Bijzonder Onderzoeksfonds Limburgs Universitair Centrum : BOF98K03 Niet-parametrisch schatten in regressiemodellen met gecensureerde data.

- Herman Callaert

1997. Vlaamse gemeenschap. Actie ter stimulering van Vlaamse deelname aan EU-onderzoeksprogramma’s. Research on Statistical education in an information technology society.

7. Samenwerking met andere wetenschappelijke instellingen en onderzoekers

72. Verblijf van buitenlandse onderzoekers aan het LUC

Jan DIJKSTRA, T.U. Eindhoven, Nederland 8 januari 1997; multivariate analysis; onderzoek; financiering : individueel akkoord. Olaf GEFELLER, Universität Göttingen, Duitsland 6 januari - 7 maart 1997; nonparametric statistics, onderzoek; financiering : Human Capital and Mobility. Louise RYAN, Harvard University, Boston, U.S.A. 26 januari - 1 februari 1997; clustered data; onderzoek; financiering : Nato grant.

Jeffrey HART, Texas A&M University, U.S.A. 26 februari 1997; smoothing; onderzoek; financiering : individueel akkoord. Matthias LAND, Universität Göttingen, Duitsland 5 maart 1997; epidemiologie; onderzoek; financiering : individueel akkoord. Peter van der HEIJDEN, Universiteit Utrecht, Nederland 19 maart 1997; discrete data; onderzoek en onderwijs; financiering : individueel akkoord. Jana JURECKOVA, Charles University, Prague, Tsjechische Republiek 12 maart 1997; robust estimation; onderzoek; financiering : individueel akkoord. Mike KENWARD, University of Kent at Canterbury, U.K. 15-16 maart 1997; sensitivity analysis; onderzoek; financiering : individueel akkoord. Carmen CADARSO-SUAREZ, University of Santiago de Compostela, Spanje. 1 april - 30 juni 1997; proportional hazards estimation; onderzoek. financiering : Human Capital and Mobility. Mary FOULKES, SmithKline Beecham, Rixensart 9 april 1997; statistics for clinicians; onderzoek; financiering : individueel akkoord. Luc DUCHATEAU, ILRI, Nairobi, Kenya 14-18 april 1997; mixed models; onderzoek; financiering : individueel akkoord. John FRESEN, University of South Africa, Pretoria 29 april - 1 mei 1997; robust regression; onderzoek; financiering : individueel akkoord. David HARRINGTON, Harvard University, Boston, U.S.A. 1 mei - 30 juni 1997; survival analysis; onderwijs en onderzoek; financiering : LUC Mike KENWARD, University of Kent of Canterbury, U.K. 19-23 mei 1997; sensitivity; onderzoek; financiering : RSS Three Country Corner local group. Paige WILLIAMS, Harvard University, Boston, U.S.A. 14-22 april 1997; clustered binary data; onderzoek;

financiering : Nato grant.

Hoffie LEMMER; Rand Afrikaanse Universiteit 25-26 juni 1997; actuarial mathematics; onderzoek; financiering : individueel akkoord. Jeffrey HART, Texas A&M University, U.S.A. 20 augustus 1997 - 20 juni 1998; smoothing; onderzoek en onderwijs; financiering : BOF Project Jacobo DE UNA-ALVAREZ, University of Vigo, Spain 23-25 september 1997; Koziol-Green models; onderzoek; financiering : individueel akkoord.

73. Gemeenschappelijk verricht onderzoek

Samenwerking met :

- Michael Akritas (Penn State University, U.S.A.)

. Ingrid Van Keilegom, Noël Veraverbeke

. Regression with censored data (IVK)

. Simulatiestudie (IVK, NV)

. Individueel akkoord en FWO

. 17 maart - 29 april 1997 : Van Keilegom in Penn State - Mark Handcock (Penn State University, U.S.A.)

. Paul Janssen

. Relative density estimation and polarization measures

. Individueel akkoord - Ricardo Cao (Univ. de la Coruna, Spain)

. Paul Janssen, N. Veraverbeke

. Relative density estimation with censored data

. Estimation of the probability of censoring

. Individueel akkoord - Carmen Cadarso-Suarez (Univ. Santiago de Compostela, Spain)

. Noël Veraverbeke

. Koziol-Green model

. European Human Capital and Mobility

. Programme ERB CHRX-CT 940693

. 1 april 1997 - 30 juni 1997 : Cadarso in LUC - Olaf Gefeller (Universität Göttingen, Duitsland)

. Noël Veraverbeke, Ingrid Van Keilegom

. Nonparametric estimation with censored data

. European Human Capital and Mobility Programme ERB CHRX-CT 940693

. 6 januari - 7 maart 1997 : Gefeller in LUC

. 13 - 20 september 1997 : Van Keilegom in Göttingen

- Luc Duchateau (I.L.R.I., Nairobi, Kenya) . Paul Janssen . Power properties in small experiments . Mixed models in veterinary research . Individueel akkoord . 14 - 18 april 1997 : Duchateau in LUC

- Jeffrey Hart (Texas A&M University, College Station, U.S.A.)

. Marc Aerts, Gerda Claeskens

. Identificatie van parametrische modellen via niet-parametrische schatters

. BOF project

. 20 augustus 1997 - 20 juni 1998 : Hart in LUC - Mike Kenward (University of Kent at Canterbury, U.K.)

. Geert Molenberghs, Bart Michiels, Herbert Thijs

. Sensitivity analysis for non-random non-response models; belief functions

. Individueel akkoord + FWO Research Project + Three Country Corner RSS Local Group

. 15 - 16 maart 1997 : Kenward in LUC 19 - 23 mei 1997 : Kenward in LUC 21 - 23 oktober 1997 : Molenberghs, Goetghebeur, Verbeke, Michiels, Thijs in Canterbury.

- Louise Ryan, Paige Williams, Paul Catalano, David Harrington (Department

of Biostatistics and Dana Farber Cancer Institute, Boston, U.S.A.) . Geert Molenberghs, Helena Geys, Els Goetghebeur . Likelihood for multivariate clustered binary data . Pseudo-likelihood for clustered data . Generalized estimating equations for clustered binary data . Subject-specific covariates . Interval censured data. EM algorithms and partial likelihood . Nato Grant CRG 950648 + FWO . 26 januari - 1 februari 1997 : Ryan in LUC

14 - 22 april 1997 : Williams in LUC 10 - 17 december 1997 : Molenberghs in Boston 1 december 1997 - 11 januari 1998 : Geys in Boston

Activiteitenverslag Voordrachten in het binnenland op uitnodiging van instellingen of organisaties

- Paul Janssen

. 2 december 1997 : Centrum voor Statistiek, Universiteit Gent. Smoothing in action.

- Marc Aerts . 16 april 1997: Institut de statistique, Louvain-la Neuve.

Parametric Bootstrap for pseudo-likelihood models. - Geert Molenberghs

. 27 juni 1997 : European Organization for Research and Treatment of Cancer, Brussels. Criteria for the validation of surrogate endpoints in randomized experiments (with M. Buyse).

. 29 september 1997 : Symposium : Don’t miss it : Statistical Analysis acknowledging the presence of missing data, Gent. The land of missing data : a guided tour.

. 15 oktober 1997 : Institut de Statistique, Louvain-la-Neuve. Likelihood based methods for multivariate and longitudinal categorical data, with dropout.

- Ingrid Van Keilegom . 5 februari 1997 : Seminars in Statistics, LUC.

Least squares estimation for censored heteroscedastic regression models via transfer of tail information.

- Helena Geys 27 mei 1997 : Centrum voor Statistiek, Universiteit Gent. Inference for pseudo-likelihood methods.

- Bart Michiels . 9-10 oktober 1997 : 5th Annual Meeting of the Belgian Statistical Society, Mol.

Protective estimation of longitudinal categorical data with nonrandom dropout. . 16 april 1997 : Seminars in Statistics, LUC.

Selection Modelling versus pattern-mixture modelling for longitudinal data with dropout.

- Els Goetghebeur . 12 maart 1997 : Annual Meeting of the Quetelet Society, LUC.

Estimating the effect of observed and experimental exposure : tales of opportunity, limitations and risks.

. 13 juni 1997 : Symposium “Analysis of Recurrent Events”, Allumni Biostatistics, Hasselt. (samen met D. Harrington)

. 18 november 1997 : ‘Pharmacoepidemilogie in het Ziekenhuis, Studiedag Vlaamse Ziekenhuisapothekers, UCB Pharma, Eigenbrakel. Inleidende begrippen uit en begrippen van farmacoepidemiologie.

. 4 december 1997. Second lowland minisymposium on drug exposure, Universiteit Gent. Non-compliance and dose-response relations.

- Geert Verbeke . 22 januari 1997 : FWO Research Community ‘Formal models in cognition’,

Leuven. The analysis of longitudinal data using linear mixed models.

. 8 april 1997 : Centrum voor Statistiek, Universiteit Gent. The effect of misspecifying the random-effects distribution in linear mixed models.

. 9-10 oktober 1997 : 5th Annual meeting of the Belgian Statistical Society, Mol. Diagnostics for linear mixed models in the context of longitudinal data.

- Peter van der Heijden . 19 maart 1997 : Seminars in Statistics, LUC.

Incorporating continuous explanatory variables in latent class analysis.