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RIZATRIPTAN

GENERIC NAME: Rizatriptan benzoate

PHARMACOLOGICAL CLASS: Serotonin 5-HT-Receptor Agonists; AntimigraineAgents

ATC CODE: N02CC04

PRACTICE INSIGHTS:• Patients taking propranolol !imit "ose to 5 mg P# an" "o not e$cee" %5 mg&24

'rDOSE

ADULT:

Migraine Headache

Oral

 

5-%0 mg at onset o( s)mptoms; repeat "ose a(ter 2 'o*rs i( necessar); not to

e$cee" +0 mg&24 'r

PEDIATRIC:

Migraine Headache

Oral

• , )ears Sa(et) an" e.cac) not establis'e"

• -%/ )ears ,40 kg1 5 mg #

• -%/ )ears 40 kg or greater1 %0 mg #

DOSE ADJUSTMENT

Hepaic i!pair!en

• No "osage a"3*stment proi"e" in man*(act*rers labeling

Renal i!pair!en

 

No "osage a"3*stment proi"e" in man*(act*rers labeling

INDICATIONS "OPTIONAL#:

PREGNANC$ % LACTATION:

• Categor) C

•  6$creting in breast milk *nkno7n; *se 7it' ca*tion in breast(ee"ing

MODE O& ACTION: 8t ca*ses asoconstriction an" re"*ces in9ammation associate"

7it' anti"romic ne*ronal transmission linke" to relie( o( migraine

 AD'ERSE DRUG REACTIONS:()*+

 

izziness : "ro7siness: (atig*e

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),)*+

 

Ast'enia: c'est pain : "izziness: "r) mo*t' :")spnea : 'ea"ac'e ':ot

9as'es:')poest'esia: pain&press*re in c'est: neck: t'roat: 3a7: palpations:

parest'esia: skin 9*s'ing somnolence

-)+

 

Angioe"ema: arr')t'mias: bra")car"ia: epi"ermal necrol)sis: 'all*cination:

'earing impairment: ')pertensie crisis: m)ocar"ial in(arction an" coronar)

arter) asospasm in patients 7it' ca" risk (actors: tac')car"ia: 7'eezing

DRUG INTERACTIONS:

CONTRAINDICATIONS % .ARNINGS:

• Contrain"icate" ino H)persensitiit)o 8sc'emic 'eart "isease: *ncontrolle" ')pertension: or ot'er signicant

car"ioasc*lar "isease

o Coronar) arter) asospasmo Perip'eral asc*lar "iseaseo