1. 2122013 noviotech BVbringing technologies to the marketTitel presentatie: van Glucose Sensor tot Hydrogel31 januari 2013www.noviotech.comMolenveldlaan 436523 RJ, NijmegenThe NetherlandsTel. +31 24 71 14 015 1

2. 2122013OrganisatiePrivate onderneming, onafhankelijkOpgericht in 2011 door Hanssen/TweehuysenAandeelhouders:Tweehuysen Holding BVHanssen Investment and Consultancy BVProf. dr. Ir. Jan C.M. van Hest (RU, Bio-organische chemie)Prof. dr. Alan E. Rowan (RU, Moleculaire materialen)Wetenschappelijk adviseurs:Prof. dr. Jan van Hest,Prof. dr. Alan Rowan enProf. dr. Roeland Nolte (oud directeur IMM, lid KNAW, leerstoelmacromoleculaire chemie, polymeer- en nanotechnologie) Samenwerking met de Radboud Universiteit: 2 3. 2122013 Bron: website Radboud Universiteit Samen met Noviotech, commercieel partner van de Radboud Universiteit en het Radboud Universiteit Medisch Centrum, worden verschillende richtingen onderzocht.Bron: NRC van25 januari 2013,wetenschapsbijlage 3 4. 2122013 Bron: de Gelderlander van 26 januari 2013: Samen met het bedrijf NovioTech kijken de scheikundigen hoe de stof in de medische wereld kan worden toegepast.Medewerkers NovioTechBV/NovioSense BVMSc Margo GroeneveldMSc Hans HanssenMSc Jan LaukoDr. Hera LichtenbeldDr. Marco ThioIr. R. TweehuysenMSc. Jeroen van der VeldenDr. Chris Wilson4 5. 2122013Doel van de presentaties Valorisatie van kennis: Innovation gap, Valley of Death valorisatie van kennis, kan dat beter ?? Daartoe aan de hand van concrete voorbeelden: Portfolio en werkwijze NovioTech BV a.d.h. van : NovioSense glucose sensor NovioHelix thermogel Nanowipe 5 6. 2122013NanoWipe Contacts with Potential End Users (DSM Resolve) and Instrument Manufacturers (NanoSight UK)6 7. 2122013Impressie van NovioTech alsPijplijn, spin-off en nieuwe ontwikkelingenLaagdrempelig voor onderzoekers met interesse in hetopzetten van een bedrijf, opdoen van ervaringBreed netwerk met bedrijven in LS en maakindustrieOpen innovatie!7 8. Introducing NovioSenseBVDr. Christopher WilsonDrs Margo Groeneveld 9. TelemedicineTelemedicine is not new:Native Americans use smoke signals to warn of illnessPeople in Remote Areas use two-way radio tocommunicate with doctorsMedicine at a Distance:Consultation via e-mail, telephone or video conferenceReal-time single point data and trend analysisDynamic and responsive healthcare regimen changes 10. Telemedicine Services 11. A New Paradigm in ChronicDisease Management 12. Disease progress often advanced before diagnosesTreatment as symptoms emergeSignificant burden on healthcare 13. Early disease detectionTreatment of cause before symptoms presentReduced burden on healthcare 14. Early disease detection and early disease managementReal-Time management of chronic conditionsReduced Burden on Healthcare and Increased Quality of Life 15. Remote MonitoringPatient EmpowermentReal-Time data for clinician evaluationWearable SensorsImplantable / Non-ImplantableWireless / WiredContinuous / On-DemandOnline / OfflineStandalone / Networked 16. Continuous Glucose MonitorsFinger Prick Glucose Single Snapshot in TimeContinuous Montior Follows Glucose Trends in TimeAlerts for oncoming highs and lowsAlerts during resting hoursCorrelate effects of diet and exercise on glucose levelsCGM results in tighter glucose control, high patientcompliance and reduction in hospital visits 17. Market Bottom line CGM use reduces costs to the insurer! CGM Statistics Collected in the Netherlands1 Hospital admision reduced by upto 80% Severe Hypoglycemia reduced by 85%1. British Journal of Diabetes and Vascular Disease 2011, 11, 3, 145-149 18. Invasive CGM 19. Wouldnt it be great to have a non-invasive CGM device? 20. Non-Invasive Glucose Sensor 21. NovioSense BVHealthInnovation FundI 20%Fraunhofer PPM OostGesellschaft 20% 15%NovioTech BV NovioSenseCEO40%BV 5% 22. Continuous Monitoring In Tears Sendingsignalto receiveringlassesAmplifyingsignalandtransmitiontoinsulinpump 23. NovioSense 24. Thanks to Science MeetsBusiness for Support 25. NovioHelix MarcoThio 26. AboutmeHLORU1994 nowTechnician PhD NovioTech biochemistry biology Val 27. Mt.NovioHelix thesummitdealscustomers team marketstudyIPideas 28. thermoreversible customizable mimicsECMNovioHelixbiocompatiblenanosizedpores4C 37C optically>99.95%water transparentTakeonekilogramofpolyisocyanidepolymer.SprinkleliberallyacrossanOlympicswimmingpool.Warmgently.Withinminutes,yourjellyisready.Serves25million.(A.Rowan,Radboud)Icantthinkofanothersyntheticmaterialthatshowsthisspecificbehavior,(D.Weitz,Harvard)thefirstsemiflexiblesyntheticpolymerstohavetunableproperties,(M.Gardel,Univ.ofChicago) 29. NovioHelix:ideasDrugCellCultureCosmetics Household Woundcare Delivery andmanymanymore... 30. NovioHelix:marketNovioHelix:IP RadboudUniversity DrugCellCulture Cosmetics Household WoundcareDeliveryexcl.worldwidelicense >$6B>$170B >$20B >$10B NovioTechmarketsizecompetitorskeyplayersprospects 31. Mt.NovioHelixdealscustomers team marketstudyIPideas 32. NovioHelix:teamBusinessDevelopment TechnicalsupportHeraLichtenbeld AlanRowanMarcoThio ChrisWilson JeroenvanderVelden 33. Mt.NovioHelixdealscustomers team marketstudyIPideas 34. SMB:2011HighhangingfruitLowhangingfruit 35. Customerapproach coldcalling tradefairs network clinicians EnterpriseEuropeNetwork ... 36. NovioHelix:customers2013 Highhangingfruitverypromising Surprisingapplicationsinhousehold Largeinterestfromcosmetics 37. Mt.NovioHelixdealscustomers team marketstudyIPideas 38. NanowipeHeraLichtenbeld - Confidential - 39. NanotechnologyWhat is it and why it matters...ArrangingAtomsNow:Legoblockshandled withboxing glovesNanotech:Take off boxinggloves - Confidential - 40. Market Segments & GRAll new products didnt exist 10 yrsago Fast growing marketPowders best penetrated now, other markets still need growth and follow later - Confidential - 41. Nano Risk ManagementNew technology challenge is in the Potential RisksNanomaterial properties differ from bulk counterpart (potentialhazard)Extreme small properties allow for easy absorption in humans(exposure) x= HazardExposure Risk - Confidential - 42. Focus on exposure: new tools requireddetect ?NanoWipe x=Hazard Exposure - Confidential - 43. Nanowipe Tunable thermosensitive hydrogel Nanowipe prototypedeveloped & proof ofprinciple studies doneindustry standard E2834-12 (ASTM standard fornanoparticle analysis similar to ISO standards)- Confidential - 44. NanoWipe - competitionCompetition comes from aerosol instruments & other wipes