AAGCACCGTTGCTCGCATGGAAGCCGGGACTGCAGCTGCCTGCAATCTGGACCTTCCC ... · • ISMB-2015 was the 23rd edi3on...
21
AAGCACCGTTGCTCGCATGGAAGCCGGGACTGCAGCTGCCTGCAATCTGGACCTTCCCGCCTATTCGCGAGAGCGTTTTAAAAGACCGTTGCGCGTGAACGTGATACACCCAGATCTTGGACTTGGTTCGTTTCGTTCAG CTAACTGTTAATTCGACTGAATATATATTCAGGTGGAGCGGAGCGTCTTGTTTTGGACTTCGTGCGTGCATCTTCTTCACTCGGTCACCAGGTAAGACTTCTCGATCGTGTTAACTTGCGTTGAAGAGCTCTGGTTGACGG AGTGATCAGGTCACACTCTATACCGCACACCATGATGAGAAGAGATGTTTTGAAGATACAGTCACTGCAGGTGAGTCGCATTTTAGACTTCGACAGGCGACTTATCAGAAATAATCTCGTGTAGAAGGCAAACGTGTAC CGTGGATACATCTTCACGCAACAGTACTCCCACGGAGTGTTTTCAGACGTTTACACGCTATTTGCGCGAGTCTTCGATGTCTTTGGCTTGTGGTACGCCCTTCTTAAAGGTTATTTCCGTACGAATATGAACTTCTACACGT CAGTTTGTCGCTCTATGGAAAGACTACGGGAAAGTTGACGTGTGGTTCTTGGATCAGGTAAGCGCCAGTAACCATGTTTTGCTGCTCAAGCTTACAATTGAAGGTGCCACTGCCACTGATCGTGCTCAAATTATTCGCGC AGAGAACAGTTTTTTACTGTCACTTCCCGGACTGTCTGCTATCTTCTCACGACACACTACTCAAACAGCTCTACCGCCTGCCAATAGACTACATTGAAGAAAGTTGTATCGGGATGGTGAGTGCTCTATTCCATTTTATGCA CGTTTTCTTTTCTTACATCCACTAGGCTGATGAGGTAGTCGTCAATAGTTATTTCACGCAAGAGATGTTCGCACAAACTTTCCAACGGCTGTTTGTGAGGGGAGTTTGCCCCAAAGTCGTTTATCCAACGGCATCCTTTGA GGTGGTAAACTCTATGTTTCAAAGCAGTCCAATACTAACTGTGATTGTACAAGGCTGAACCTTGCATCGAAGAAACGGTACAGCGACGTCTGCAACACGAATTTGGCCAAGCAACTGCACTGAAATGGAGGTACTGAAA GTTGATTCCAATTGCAGCTTAAATATAACTCCTTTGTTAGCCAAAAGACGATATTCCTATCGTTAAACCGCTTCGATTCAAAGAAGAATCTATCCCTTGCGATTCACGCATTCTACGACTTCAGTCAACAAATTCAACAGTC AACTCCTAAACATGGACACGTTTTAATTATCGCAGGAGGCTTCGATGCAAGGCTATCTGATAATGTGAAGACGTTGGATGCTCTCGTCAGGTAAGTTGTGAGAGTCAGGTTATATGCAATCTAGTCCTAAGATGTACGAT AAATAGCCTCACTAGAGAACTCGGCGTATCTGATGATGTTTTCTTCTTACCGTCAGTAAGTAAGAGTCAGAAGGAAGCGCTGTTGAGTTGCAGCATGAGCATCATTTACACACCGGAGCACGAGCACTTCGGTATAGTC CCACTCGAGGCTATGTGTTATCAAAAACCCGTGATAGCGTGCAACAGTGGTGGCCCGAGAGAAACAGTGATACATGGTTTGACAGGTTTCCTATGCGAAAGTAACCCAGAGGTAACATTGTACCATAACTACAACTGCT TGCAGCTCAGACGCGCGCAGAGTTTTGCACGAGCAATGATTAGACTTTCAAACACTCCAAAGCTTGCAAAGGAGATGGGTGTCGCAGCAAAGACATACTTTAACGAGCATTTTCATATGTCGGCGTTCATACGTAACAC AGAGTGTGTTTTACAAACAAGTATGACAGTGCAGCCAATCAATCGCGATGTCCCTGGAAGACTTCGGCTATCATTCTACATCATACTTTTCACGCAACTCTGTTGGCGTTACTTGTCCGTTCTCAGTACTCCTGAGCCGCA CTCAGCCAGAACGCATGTCGCAGTGATTCAGCGCTCATACAAACGCAAAAAATTGTAAACCACTGCGTGAATCTCTGTGTGCTATAACTCACATGTCCACACTCATAGCGCTAAGAGTTGTGCGAACCAAGCTGCTGCGC TCTTCGTTGTACATCGTATGGAGTACCCCCACATACTTTTGAGGATATCATGCGGGCATCACCAAAGAATATCGCAAGAGAGAAACACGTTCGATGTTTGAATTTGGCACGAAATTTTTGCGTGTTCGCAAACGATATGA AAATAAGAGTCAAAGAGAAGGGGCAAGAGACAGGAGCGTAAACTTCCAACGCCAGGAGAACTCTTCTACCGCATTGATTTAGCTTCCTATTCGTCATAGTCATACATCATGTAGAGTAACGGCAAACAATATCCCAGCG GCTACTCTTAGCTGAAGTTGAAACATACTTCACGAAGTCACCAATTCCAGTGTTGACCTTTACGAGTGAAAGGCAGTTGAACGATGGAGTGACTGAGCGCATGTTCTGTTCTTCCCCTATTTCCTCGTATACATCTGCTCG ATCGCTCTTGGAACCGATCGGGATGAAACACTTGAAGCCTCCAAGATCACCGGATAGCCATTCAGCAGGATTTGGACCGCTTGTAAGACAAAGTGTCACATCTATTTCAGAGCTGCAACGTTTTGTACCGGCGTGTGCC AGGGTGTAATCAAAACCCGGGCGAAAGCGCCGGACCTCAGAGTGTGCAAGATCGCAAACACTACCGGTTACGGCTCTAACCCAGTTTTGAAAAGAAGAAGATTCAAATAAATCGCACATCAGCTTTTTTAACAATTCAC CACTGTTGCTTCGCTTGTTTGCAAGAGTGCATTCAAGGGGTTGGTAGCTTAAATATCGCTGAACGTGTGGAGGGCCTTGAACAACCCAACTGTCCCCATAGCCGTGATCATACATGCAGCGGTGTCTACTATTTCGGCAA TCTTCACGGTTTAGTTTTCTCTTAATCGGCTCAGCTATATGGGGCAAAAGGAAATTGAATAACTGAACTGAGCCATCAGCCTCGAATACCTGTCGGACTCGTTTCACACTTTCCGAACGCAGGTATTCTGGATTGATCCAC TTAGTGAGGTCCTGTACAAGTGAGTAAGAAGGAGATAACACACGATTAACGTGGAGAACTGCCCACTCCGCGTGTGTAGCTGGAATCATTGAGTGGAGTTGGTCCAACGTTGACGTCTCTCTCTGGTTTCTCTTAATAT GGCGTTCTTTTGTATGAAACCAACCCGAAATGCTTACTCTCGTTTTCATCTCTGCACTCACTTCTCGGACAGCGTGAAAGCTACGCCCAGGCGAAACCTCAAACATGACCATGGAGTTCCAACTTGGAAGTATGGAAACC ACAGGCGTGTGAGTTGGTACCGTGCGCCGATCGCTTGCGTATAACTCAAGTTGTCCTCCGTCTACAGCAAGCCAGTCACAGTCCGGATCGGATAGATATATGATGTAAGAAATTTTTCGAGTGCCGATCACGTCATCGT GGCAAAGAAGGTGACAACCAGATGTATAAATGTTGCAGGAGCAATCGACCGCTCCATCAAGCGGACCGGTGCCTGTAACAGTGGAAACAAAACCTCGAAATCCAGGAGAATACAAGTGCTCTCGAAGCCGAATCAAG TTGGGCACGTTTGTATGCGCGTCCCTGATGCAATCCTCTAGATTTGCCAAATCCGTTGTCTGAAAAACTTTGAACAAGTCGGTCTCCTTGAAATGCGCCGTCAAATAGCTCTTGAGTTCTTTGAGGCATTCTCGCAAAAAG GTATCGTCAAACACGTCTTCAAAAGCAACGTAGGGATATGGATTGATGTTGACCACAGAATTATCAGCGTTCCTGAGGAATTGCGCGAACGAATGTGAGTAGATATGGTCGGGCATATGCCTACCGAGGACGAGAGTT TCGACAACTGGCGTCTCGTTCTGTTATTGGGCGAGACCCCATCAGTGCTGACACTGATAGACCTAGACTGTGAGCGAGTAGGCACAAAGTAGACGCACTTAGAAAGTTAGGACTGCGCTTTGCGTTACAAACATCATAA TTCTAAAAATTTTCGCTTTCTATCATGTCAAGTTCGCCCTGAGAATGACATATGAGATTGAGAGCAAAACAAGACAAAGGAAAGAACGCACCCCAACTGTGTCCAACTTCGTCTGCAAAATGTGCACAGCTTGCAGAACA ATTTCCTCCGCATCAAGCACGCCAGTTGACTCAACGTGCAACTCTGTTGGCGTTACTTGTCCGTTCTCAGTACTCCTGAGCCGCACTCAGCCAGAACGCATGTCGCAGTGATTCAGCGCTCATACAAACGCAAAAAATTGT AAACCACTGCGTGAATCTCTGTGTGCTATAACTCACATGTCCACACTCATAGCGCTAAGAGTTGTGCGAACCAAGCTGCTGCGCTCTTCGTTGTACATCGTATGGAGTACCCCCACATACTTTTGAGGATATCATGCGGGC ATCACCAAAGAATATCGCAAGAGAGAAACACGTTCGATGTTTGAATTTGGCACGAAATTTTTGCGTGTTCGCAAACGATATGAAAATAAGAGTCAAAGAGAAGGGGCAAGAGACAGGAGCGTAAACTTCCAACGCCA GGAGAACTCTTCTACCGCATTGATTTAGCTTCCTATTCGTCATAGTCATACATCATGTAGAGTAACGGCAAACAATATCCCAGCGGCTACTCTTAGCTGAAGTTGAAACATACTTCACGAAGTCACCAATTCCAGTGTTGA CCTTTACGAGTGAAAGGCAGTTGAACGATGGAGTGACTGAGCGCATGTTCTGTTCTTCCCCTATTTCCTCGTATACATCTGCTCGATCGCTCTTGGAACCGATCGGGATGAAACACTTGAAGCCTCCAAGATCACCGGAT AGCCATTCAGCAGGATTTGGACCGCTTGTAAGACAAAGTGTCACATCTATTTCAGAGCTGCAACGTTTTGTACCGGCGTGTGCCAGGGTGTAATCAAAACCCGGGCGAAAGCGCCGGACCTCAGAGTGTGCAAGATCG CAAACACTACCGGTTACGGCTCTAACCCAGTTTTGAAAAGAAGAAGATTCAAATAAATCGCACATCAGCTTTTTTAACAATTCACCACTGTTGCTTCGCTTGTTTGCAAGAGTGCATTCAAGGGGTTGGTAGCTTAAATAT CGCTGAACGTGTGGAGGGCCTTGAACAACCCAACTGTCCCCATAGCCGTGATCATACATGCAGCGGTGTCTACTATTTCGGCAATCTTCACGGTTTAGTTTTCTCTTAATCGGCTCAGCTATATGGGGCAAAAGGAAATT GAATAACTGAACTGAGCCATCAGCCTCGAATACCTGTCGGACTCGTTTCACACTTTCCGAACGCAGGTATTCTGGATTGATCCACTTAGTGAGGTCCTGTACAAGTGAGTAAGAAGGAGATAACACACGATTAACGTGG AGAACTGCCCACTCCGCGTGTGTAGCTGGAATCATTGAGTGGAGTTGGTCCAACGTTGACGTCTCTCTCTGGTTTCTCTTAATATGGCGTTCTTTTGTATGAAACCAACCCGAAATGCTTACTCTCGTTTTCATCTCTGCAC TCACTTCTCGGACAGCGTGAAAGCTACGCCCAGGCGAAACCTCAAACATGACCATGGAGTTCCAACTTGGAAGTATGGAAACCACAGGCGTGTGAGTTGGTACCGTGCGCCGATCGCTTGCGTATAACTCAAGTTGTCC TCCGTCTACAGCAAGCCAGTCACAGTCCGGATCGGATAGATATATGATGTAAGAAATTTTTCGAGTGCCGATCACGTCATCGTGGCAAAGAAGGTGACAACCAGATGTATAAATGTTGCAGGAGCAATCGACCGCTCCA TCAAGCGGACCGGTGCCTGTAACAGTGGAAACAAAACCTCGAAATCCAGGAGAATACAAGTGCTCTCGAAGCCGAATCAAGTTGGGCACGTTTGTATGCGCGTCCCTGATGCAATCCTCTAGATTTGCCAAATCCGTTG TCTGAAAAACTTTGAACAAGTCGGTCTCCTTGAAATGCGCCGTCAAATAGCTCTTGAGTTCTTTGAGGCATTCTCGCAAAAAGGTATCGTCAAACACGTCTTCAAAAGCAACGTAGGGATATGGATTGATGTTGACCACA GAATTATCAGCGTTCCTGAGGAATTGCGCGAACGAATGTGAGTAGATATGGTCGGGCATATGCCTACCGAGGACGAGAGTTTCGACAACTGGCGTCTCGTTCTGTTATTGGGCGAGACCCCATCAGTGCTGACACTGAT AGACCTAGACTGTGAGCGAGTAGGCACAAAGTAGACGCACTTAGAAAGTTAGGACTGCGCTTTGCGTTACAAACATCATAATTCTAAAAATTTTCGCTTTCTATCATGTCAAGTTCGCCCTGAGAATGACATATGAGATT GAGAGCAAAACAAGACAAAGGAAA 30 years of Bioinforma3cs 21 in Belgium Pierre Rouzé Ex-Bioinforma3cs & Evolu3onary Biology, VIB department of Plant Systems Biology, U.Gent Heiligenborre 154D Brussels
Transcript of AAGCACCGTTGCTCGCATGGAAGCCGGGACTGCAGCTGCCTGCAATCTGGACCTTCCC ... · • ISMB-2015 was the 23rd edi3on...
AAGCACCGTTGCTCGCATGGAAGCCGGGACTGCAGCTGCCTGCAATCTGGACCTTCCCGCCTATTCGCGAGAGCGTTTTAAAAGACCGTTGCGCGTGAACGTGATACACCCAGATCTTGGACTTGGTTCGTTTCGTTCAGCTAACTGTTAATTCGACTGAATATATATTCAGGTGGAGCGGAGCGTCTTGTTTTGGACTTCGTGCGTGCATCTTCTTCACTCGGTCACCAGGTAAGACTTCTCGATCGTGTTAACTTGCGTTGAAGAGCTCTGGTTGACGGAGTGATCAGGTCACACTCTATACCGCACACCATGATGAGAAGAGATGTTTTGAAGATACAGTCACTGCAGGTGAGTCGCATTTTAGACTTCGACAGGCGACTTATCAGAAATAATCTCGTGTAGAAGGCAAACGTGTACCGTGGATACATCTTCACGCAACAGTACTCCCACGGAGTGTTTTCAGACGTTTACACGCTATTTGCGCGAGTCTTCGATGTCTTTGGCTTGTGGTACGCCCTTCTTAAAGGTTATTTCCGTACGAATATGAACTTCTACACGTCAGTTTGTCGCTCTATGGAAAGACTACGGGAAAGTTGACGTGTGGTTCTTGGATCAGGTAAGCGCCAGTAACCATGTTTTGCTGCTCAAGCTTACAATTGAAGGTGCCACTGCCACTGATCGTGCTCAAATTATTCGCGCAGAGAACAGTTTTTTACTGTCACTTCCCGGACTGTCTGCTATCTTCTCACGACACACTACTCAAACAGCTCTACCGCCTGCCAATAGACTACATTGAAGAAAGTTGTATCGGGATGGTGAGTGCTCTATTCCATTTTATGCACGTTTTCTTTTCTTACATCCACTAGGCTGATGAGGTAGTCGTCAATAGTTATTTCACGCAAGAGATGTTCGCACAAACTTTCCAACGGCTGTTTGTGAGGGGAGTTTGCCCCAAAGTCGTTTATCCAACGGCATCCTTTGAGGTGGTAAACTCTATGTTTCAAAGCAGTCCAATACTAACTGTGATTGTACAAGGCTGAACCTTGCATCGAAGAAACGGTACAGCGACGTCTGCAACACGAATTTGGCCAAGCAACTGCACTGAAATGGAGGTACTGAAAGTTGATTCCAATTGCAGCTTAAATATAACTCCTTTGTTAGCCAAAAGACGATATTCCTATCGTTAAACCGCTTCGATTCAAAGAAGAATCTATCCCTTGCGATTCACGCATTCTACGACTTCAGTCAACAAATTCAACAGTCAACTCCTAAACATGGACACGTTTTAATTATCGCAGGAGGCTTCGATGCAAGGCTATCTGATAATGTGAAGACGTTGGATGCTCTCGTCAGGTAAGTTGTGAGAGTCAGGTTATATGCAATCTAGTCCTAAGATGTACGATAAATAGCCTCACTAGAGAACTCGGCGTATCTGATGATGTTTTCTTCTTACCGTCAGTAAGTAAGAGTCAGAAGGAAGCGCTGTTGAGTTGCAGCATGAGCATCATTTACACACCGGAGCACGAGCACTTCGGTATAGTCCCACTCGAGGCTATGTGTTATCAAAAACCCGTGATAGCGTGCAACAGTGGTGGCCCGAGAGAAACAGTGATACATGGTTTGACAGGTTTCCTATGCGAAAGTAACCCAGAGGTAACATTGTACCATAACTACAACTGCTTGCAGCTCAGACGCGCGCAGAGTTTTGCACGAGCAATGATTAGACTTTCAAACACTCCAAAGCTTGCAAAGGAGATGGGTGTCGCAGCAAAGACATACTTTAACGAGCATTTTCATATGTCGGCGTTCATACGTAACACAGAGTGTGTTTTACAAACAAGTATGACAGTGCAGCCAATCAATCGCGATGTCCCTGGAAGACTTCGGCTATCATTCTACATCATACTTTTCACGCAACTCTGTTGGCGTTACTTGTCCGTTCTCAGTACTCCTGAGCCGCACTCAGCCAGAACGCATGTCGCAGTGATTCAGCGCTCATACAAACGCAAAAAATTGTAAACCACTGCGTGAATCTCTGTGTGCTATAACTCACATGTCCACACTCATAGCGCTAAGAGTTGTGCGAACCAAGCTGCTGCGCTCTTCGTTGTACATCGTATGGAGTACCCCCACATACTTTTGAGGATATCATGCGGGCATCACCAAAGAATATCGCAAGAGAGAAACACGTTCGATGTTTGAATTTGGCACGAAATTTTTGCGTGTTCGCAAACGATATGAAAATAAGAGTCAAAGAGAAGGGGCAAGAGACAGGAGCGTAAACTTCCAACGCCAGGAGAACTCTTCTACCGCATTGATTTAGCTTCCTATTCGTCATAGTCATACATCATGTAGAGTAACGGCAAACAATATCCCAGCGGCTACTCTTAGCTGAAGTTGAAACATACTTCACGAAGTCACCAATTCCAGTGTTGACCTTTACGAGTGAAAGGCAGTTGAACGATGGAGTGACTGAGCGCATGTTCTGTTCTTCCCCTATTTCCTCGTATACATCTGCTCGATCGCTCTTGGAACCGATCGGGATGAAACACTTGAAGCCTCCAAGATCACCGGATAGCCATTCAGCAGGATTTGGACCGCTTGTAAGACAAAGTGTCACATCTATTTCAGAGCTGCAACGTTTTGTACCGGCGTGTGCCAGGGTGTAATCAAAACCCGGGCGAAAGCGCCGGACCTCAGAGTGTGCAAGATCGCAAACACTACCGGTTACGGCTCTAACCCAGTTTTGAAAAGAAGAAGATTCAAATAAATCGCACATCAGCTTTTTTAACAATTCACCACTGTTGCTTCGCTTGTTTGCAAGAGTGCATTCAAGGGGTTGGTAGCTTAAATATCGCTGAACGTGTGGAGGGCCTTGAACAACCCAACTGTCCCCATAGCCGTGATCATACATGCAGCGGTGTCTACTATTTCGGCAATCTTCACGGTTTAGTTTTCTCTTAATCGGCTCAGCTATATGGGGCAAAAGGAAATTGAATAACTGAACTGAGCCATCAGCCTCGAATACCTGTCGGACTCGTTTCACACTTTCCGAACGCAGGTATTCTGGATTGATCCACTTAGTGAGGTCCTGTACAAGTGAGTAAGAAGGAGATAACACACGATTAACGTGGAGAACTGCCCACTCCGCGTGTGTAGCTGGAATCATTGAGTGGAGTTGGTCCAACGTTGACGTCTCTCTCTGGTTTCTCTTAATATGGCGTTCTTTTGTATGAAACCAACCCGAAATGCTTACTCTCGTTTTCATCTCTGCACTCACTTCTCGGACAGCGTGAAAGCTACGCCCAGGCGAAACCTCAAACATGACCATGGAGTTCCAACTTGGAAGTATGGAAACCACAGGCGTGTGAGTTGGTACCGTGCGCCGATCGCTTGCGTATAACTCAAGTTGTCCTCCGTCTACAGCAAGCCAGTCACAGTCCGGATCGGATAGATATATGATGTAAGAAATTTTTCGAGTGCCGATCACGTCATCGTGGCAAAGAAGGTGACAACCAGATGTATAAATGTTGCAGGAGCAATCGACCGCTCCATCAAGCGGACCGGTGCCTGTAACAGTGGAAACAAAACCTCGAAATCCAGGAGAATACAAGTGCTCTCGAAGCCGAATCAAGTTGGGCACGTTTGTATGCGCGTCCCTGATGCAATCCTCTAGATTTGCCAAATCCGTTGTCTGAAAAACTTTGAACAAGTCGGTCTCCTTGAAATGCGCCGTCAAATAGCTCTTGAGTTCTTTGAGGCATTCTCGCAAAAAGGTATCGTCAAACACGTCTTCAAAAGCAACGTAGGGATATGGATTGATGTTGACCACAGAATTATCAGCGTTCCTGAGGAATTGCGCGAACGAATGTGAGTAGATATGGTCGGGCATATGCCTACCGAGGACGAGAGTTTCGACAACTGGCGTCTCGTTCTGTTATTGGGCGAGACCCCATCAGTGCTGACACTGATAGACCTAGACTGTGAGCGAGTAGGCACAAAGTAGACGCACTTAGAAAGTTAGGACTGCGCTTTGCGTTACAAACATCATAATTCTAAAAATTTTCGCTTTCTATCATGTCAAGTTCGCCCTGAGAATGACATATGAGATTGAGAGCAAAACAAGACAAAGGAAAGAACGCACCCCAACTGTGTCCAACTTCGTCTGCAAAATGTGCACAGCTTGCAGAACAATTTCCTCCGCATCAAGCACGCCAGTTGACTCAACGTGCAACTCTGTTGGCGTTACTTGTCCGTTCTCAGTACTCCTGAGCCGCACTCAGCCAGAACGCATGTCGCAGTGATTCAGCGCTCATACAAACGCAAAAAATTGTAAACCACTGCGTGAATCTCTGTGTGCTATAACTCACATGTCCACACTCATAGCGCTAAGAGTTGTGCGAACCAAGCTGCTGCGCTCTTCGTTGTACATCGTATGGAGTACCCCCACATACTTTTGAGGATATCATGCGGGCATCACCAAAGAATATCGCAAGAGAGAAACACGTTCGATGTTTGAATTTGGCACGAAATTTTTGCGTGTTCGCAAACGATATGAAAATAAGAGTCAAAGAGAAGGGGCAAGAGACAGGAGCGTAAACTTCCAACGCCAGGAGAACTCTTCTACCGCATTGATTTAGCTTCCTATTCGTCATAGTCATACATCATGTAGAGTAACGGCAAACAATATCCCAGCGGCTACTCTTAGCTGAAGTTGAAACATACTTCACGAAGTCACCAATTCCAGTGTTGACCTTTACGAGTGAAAGGCAGTTGAACGATGGAGTGACTGAGCGCATGTTCTGTTCTTCCCCTATTTCCTCGTATACATCTGCTCGATCGCTCTTGGAACCGATCGGGATGAAACACTTGAAGCCTCCAAGATCACCGGATAGCCATTCAGCAGGATTTGGACCGCTTGTAAGACAAAGTGTCACATCTATTTCAGAGCTGCAACGTTTTGTACCGGCGTGTGCCAGGGTGTAATCAAAACCCGGGCGAAAGCGCCGGACCTCAGAGTGTGCAAGATCGCAAACACTACCGGTTACGGCTCTAACCCAGTTTTGAAAAGAAGAAGATTCAAATAAATCGCACATCAGCTTTTTTAACAATTCACCACTGTTGCTTCGCTTGTTTGCAAGAGTGCATTCAAGGGGTTGGTAGCTTAAATATCGCTGAACGTGTGGAGGGCCTTGAACAACCCAACTGTCCCCATAGCCGTGATCATACATGCAGCGGTGTCTACTATTTCGGCAATCTTCACGGTTTAGTTTTCTCTTAATCGGCTCAGCTATATGGGGCAAAAGGAAATTGAATAACTGAACTGAGCCATCAGCCTCGAATACCTGTCGGACTCGTTTCACACTTTCCGAACGCAGGTATTCTGGATTGATCCACTTAGTGAGGTCCTGTACAAGTGAGTAAGAAGGAGATAACACACGATTAACGTGGAGAACTGCCCACTCCGCGTGTGTAGCTGGAATCATTGAGTGGAGTTGGTCCAACGTTGACGTCTCTCTCTGGTTTCTCTTAATATGGCGTTCTTTTGTATGAAACCAACCCGAAATGCTTACTCTCGTTTTCATCTCTGCACTCACTTCTCGGACAGCGTGAAAGCTACGCCCAGGCGAAACCTCAAACATGACCATGGAGTTCCAACTTGGAAGTATGGAAACCACAGGCGTGTGAGTTGGTACCGTGCGCCGATCGCTTGCGTATAACTCAAGTTGTCCTCCGTCTACAGCAAGCCAGTCACAGTCCGGATCGGATAGATATATGATGTAAGAAATTTTTCGAGTGCCGATCACGTCATCGTGGCAAAGAAGGTGACAACCAGATGTATAAATGTTGCAGGAGCAATCGACCGCTCCATCAAGCGGACCGGTGCCTGTAACAGTGGAAACAAAACCTCGAAATCCAGGAGAATACAAGTGCTCTCGAAGCCGAATCAAGTTGGGCACGTTTGTATGCGCGTCCCTGATGCAATCCTCTAGATTTGCCAAATCCGTTGTCTGAAAAACTTTGAACAAGTCGGTCTCCTTGAAATGCGCCGTCAAATAGCTCTTGAGTTCTTTGAGGCATTCTCGCAAAAAGGTATCGTCAAACACGTCTTCAAAAGCAACGTAGGGATATGGATTGATGTTGACCACAGAATTATCAGCGTTCCTGAGGAATTGCGCGAACGAATGTGAGTAGATATGGTCGGGCATATGCCTACCGAGGACGAGAGTTTCGACAACTGGCGTCTCGTTCTGTTATTGGGCGAGACCCCATCAGTGCTGACACTGATAGACCTAGACTGTGAGCGAGTAGGCACAAAGTAGACGCACTTAGAAAGTTAGGACTGCGCTTTGCGTTACAAACATCATAATTCTAAAAATTTTCGCTTTCTATCATGTCAAGTTCGCCCTGAGAATGACATATGAGATT
GAGAGCAAAACAAGACAAAGGAAA
30yearsofBioinforma3cs21inBelgium
PierreRouzéEx-Bioinforma3cs&Evolu3onaryBiology,VIBdepartmentofPlantSystemsBiology,U.GentHeiligenborre154DBrussels
30 years, why that ?
A bit of context … • ThisanalysiswasdoneatINRAVersailles,France,butoncrowngallgenesequencesfromtheteamofMarcVanMontaguinGhent,already!
• Itwasdoneusingtheveryfewcomputertoolspubliclyavailableatthat3me,providedbyCITI2inParis,theonlyFrenchserverinexistencethen,andtheDNA&proteinACNUCdatabaseproducedinLyonbeforewebbeingexis3ng
• Ihavebeencri3ceddoingitbyseverallabscien3stscolleagues@INRAVersaillestellingthatIwasloosingmy3meplayingwithakeyboardinsteadofworkingin(wetlab)researchasIwasexpectedtodoasabiochemist…
• Otherstoldmethatitwasnotethicaltodosuchanalysisandtopublishit,asitwasrobingdataproducedbyothers…
• Gene3cswashaving(ands3llhas)astrongposi3oninFrance.TheheritageofthePasteurIns3tutewithJacob&Monodle`acrucialconceptualbackgroundinmolecular&cellbiology,e.g.intermofgeneregula3on
• Francewasalsoanimportantplaceintermofproteinstructurecomputermodeling
• Therewas/issometradi3onofinvolvingmathema3csinBiologyinFrance,maybedueto«grandesécoles»wherestudentsinBiologyarelearningmathema3csaswell.INRA(focussingonagricultureandbiotechnologies)andINSERM(focussingonmedecine)had/havebothappliedmathsdepartments
• Frenchcomputerscien3stshavebeenconfrontedtoissuesfromBiologyearlyon,beforethegenomicsdataflood.INRIA,thena3onalresearchagencyinInforma3cshasbeensuppor3veofsuchdevelopments,especially–butnotonly-inthefieldofmachinelearning
1980 – 1995 : Bioinformatics in France
• Bioinforma3csthereforeemergedquiteearlyinFrance,whichisignoredbymanyabroadprobablybecauseofalackofinterna3onalconfronta3onandtasksharing
• CoursesweregivenandcurriculainBioinforma3csforstudentswithbackgroundinBiologyorComputerScienceemergedinthelateeigh3esinseveralFrenchuniversi3es(Toulouse,Montpellier,Marseilles,Rouen/Versailles,Lyon,Paris)
• Na3onalBioinforma3csNetwork(BISANCE@CITI2)withallowinglowoutputanalysesintendedatbenchscien3stswasinplaceatthat3metoo.IwasINRArepresenta3veinthescien3ficcommigeeofthisstructurewhichwastheFrenchEMBnetnode,
• Someplaces(e.g.PasteurIns3tute&INRAresearchcenters)managedinthe90’stohavetheirownBioinforma3csfacili3eswithdedicatedsupportandintranetconnec3on
1980 – 1995 : Bioinformatics in France
1980 – 1995 : Bioinformatics in France
• Genomicshasnotbeenwelcomebythemostinfluencialscien3stsinFrance.Data-drivenapproachwasseenasleadingtoqualita3velypoorinsightintoBiologyintheabsenceofaconceptualskeleton.Besidesmanyscien3stswereafraidofseingtheirbudgetfadingawayifmoneywasallowedto(then)costlygenomicsprojects.
• Thepublicini3a3vestoini3ateFrenchgenomicsprogramsandbioinforma3cshavebeenveryerra3c
• cf.DanchinA.Abriefhistoryofgenomeresearchandbioinforma3csinFrance,2000,Bioinforma)cs,16:65-75
Bioinforma+csinEurope:1991
Maastricht 91: Bioinformatics in the 90’s
Obviouslythismee3ngcametooearlyandhasnotbeenasuccess!
ISMB, RECOMB, ISCB, ECCB • ISMB-2015wasthe23rdedi3onifthisIntelligentSystemsforMolecularBiologymee3ng.
• Thetwofirstedi3onshappenedin1993&1994intheUSA.ISMB-95(Cambridge,UK)wasthefirsttohappeninEuropeandhasbeenasuccesswith272par3cipants(seenextslide)whenitincreasedtomorethan2000by2004already
• ISCB,theInterna3onalSocietyofComputa3onalBiologyhasbeenfoundedin1997
• TheRECOMBconferenceswerealsolaunchedin1997fromthemathema3calandcomputa3onalsideofthefield,focusingmainlyoncomputa3onaladvances.
• ECCB,theEuropeanConferenceofComputerBiologyistakingplaceannuallysince2002,beingmergedwithISMBeverytwoyears.ECCB-2005wasorganisedinGhentbyYvesMoreau
• +++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++terna3onalSocietyofComputa3onalBiology,waslaunchedin1997
• ECCB-2015wasthe14thedi3onoftheEuropeanConferenceonComputa3onalBiology
Germany(IncludingEMBL): 37France 27Nordiccountries 13Italy 8Belgium(including1EU) 6Switzerland&Austria 4Spain 2
272par3cipants,162fromEuropeUnitedKingdom(includingEBI):64
April 1994 : arriving in Ghent
1994 : BioInformatics in Belgium ?
• Withoutclaimingitunderthisnamingopenly,afewteamswereinvolvedinBioinforma3csinBelgiumatthat3me(Ihopenotmissingany…):
• TherewasfirsttheteamofSoshanaWodakatULB,involvedin3DproteinstructureintheUnitédeConforma3ondesMacromoléculesBiologiquesinwhichJacquesVanHeldenwassisng,moreinterestedhimselfindecipheringpathwaysandgenefunc3on®ula3on.
• AtULBtoo,DenisThieffry,waslookingatgeneinterac3onnetworksfollowingRenéThomaslogicalapproach,whileAlbertGoldbeterwasmodelingbiologicalrythms(whichatthat3mewasnotseenaspartofBioinforma3csproper…)
• AtNamurFUNDPEricDepiereux&ErnestFeytmanswereinterestedinproteinfunc3onalsitesanddevelopedaproteinalignmentso`ware(MATCH-BOX)
• AtU.Antwerp,RupertDeWachterwasdevelopingandmaintainingsmallandlargesubunitrRNAdatabasesforphylogenyandtaxonomypurposes…togetherwiththethenveryyoungYvesVandePeer,PeterDeRijkandJean-MarcNeefs(shouldImen3onothers?)
• BEN,theBelgianEMBNetnodemanagedbyRobertHerzognodewasfullyfunc3onial,withknow-how&coursesgivenbyGuyBogu,amongothers
STWW 2000-2004 Deciphering Upstream Regulatory Sequences Using Co-
Expressed Genes • Partners
• K.U.LeuvenESAT-SISTA YvesMoreau• VIBPlantGene3cs PierreRouzé
• Strategy• Discoveryofplantpromotersthroughtheanalysisofmicroarrayexperiments• Clusteringofco-expressedgenes• Mo3fdiscoverythroughfrequencyanalysisoftheupstreamregionofcoexpressedgenes
• Goals• Produc3onandmaintenanceofadatabaseofplantpromoters• Developmentofalgorithms• Iden3fica3onofgroupsofco-regulatedgenes
• Majoroutcome• Promoteranalysisso`ware:Mo3fSampler,Inclusive• 12publica3ons• KULeuven&withitcomputerscien3stsenteredBioinforma3cs
BioMaGNet IAP 2007-2011 Coordinator:Partner1(P1)Name:BartDeMoor Ins+tu+on:K.U.Leuven–EEDept.(ESAT)/SCD(SISTA/COSIC/DocArch)Ins+tu+on’sabbrevia+on:K.U.Leuven
Partner2(P2)Name:YvesVandePeer Ins+tu+on:VIB–U.Gent–PlantSystemsBiology–Bioinforma+csandEvolu+onaryBiologyUnitIns+tu+on’sabbrevia+on:U.Gent-VIB Partner3(P3)Name:AlbertGoldbeter Ins+tu+on:ULB–Chemistry–UnitofTheore+calChronobiologyIns+tu+on’sabbrevia+on:ULB
Partner4(P4)Name:LouisWehenkel Ins+tu+on:ULg,ElectricalEngineering&ComputerScience–CBIG–Stochas+cMethods–SystemsandModelingIns+tu+on’sabbrevia+on:ULg
EU-Partner1(EU1)Name:Florenced’Alche-bucIns+tu+on:Univ.D’Evry-Vald’Essonne–Génopole–Lab.DeMéthodesInforma+ques–EquipeBioInfoIns+tu+on’sabbrevia+on:LAMICountry:France
EU-Partner2(EU2)Name:DenisThieffryIns+tu+on:UniversitéDelaMéditerrannée–AixMarseilleII–Ins+tutedeBiologieetduDéveloppementdeMarseille-Luminy-Bioinforma+queIns+tu+on’sabbrevia+on:IBDMCountry:France
bringingtogetherexper3serangingfromhigh-throughputdataanalysisandreverseengineeringtodynamicalmodelingwiththegoalofbridgingthegapbetweenthedomainsandserveasanenablerforsystemsbiology.
IAP2002-2016 abortedIAP2012-2016 rejected
Belgium Bioinformatics Conferences before
Benelux Bioinformatics Conferences
• TheveryfirstBBCwasaBelgiumBioinforma3csConferenceandtookplaceatULBBrusselsin2000.ItwasorganisedbyDenisThieffry,nowatENS,Paris
• Thenextonein2001tookplaceinGhent(seenextslide)
• BBC2002wasinNamur• BBC2003,inLeuven• BBC2004inBrusselsagain• BBC2005inGhentwasthefirsttobeaBeneluxBioinforma3csConference(seenextslide)
BBC2001inGhent
The5thedi3onoftheBeneluxBioinforma3csConference
BBC-2010
averyspecialedi3onturnedinto
ECCB10
The future of Benelux Bioinformatics
ISCBStudentCouncil2015Execu+veTeam
PieterMeysman,Chair
&previousStudentCouncilETmembersfromBenelux
ThomasAbeelBoard(2011-2012)JeroendeRidder,Chair(2010)
MagaliMichaut,Secretary(2009)
RSGNetherlandsisalsoveryac3ve,butwhereisyourlogo,guys?AndyoursRSGLuxembourg??
Thanks to … • SørenBrunak,DTULyngby,DK• ThomasSchiex,INRAToulouse,FR• MarcVanMontagu,Ghent• YvesVandePeer,Ghent• AllthecolleagueswithwhomIhavebeenworkingwithduringthosemanyyears,
• thebiologistsanddataproviders,• themanyco-workersfromourteam• andtheonescollabora3ngfromoutside…• forkeepingconfidenceandsupport,eveninthemostdifficultcircumstances…
Thanks to the organisers : this BBC-2015 meeting has been an
enlightment !
