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Have you previously received an FAOBMB Travel Fellowship? If yes, please indicate

when: No

Curriculum Vitae

Provide a brief CV showing education and research training, including any prizes orawards: (no more than one page)

RESEARCH EXPERIENCE

-Senior Research Fellow : Department of Neurology, Post Graduate Institute of Medical

Education and Research, Chandigarh. November 2010 - continue.

-Junior Research Fellow: Department of Neurology, Post Graduate Institute of Medical

Education and Research, Chandigarh. March 2008- November 2010.

AWARD

Awarded Senior Research Fellowship by Indian Council of Medical Research.

EXTRA CURRICULAR ACTIVITIES

1. Editorial Assistant of the Journal Annals of Neurosciences.http://annalsofneurosciences.org/journal/index.php/annal/about/editorialTeamBio/7

2. Design and layout for Annals of Neurosciences.3. Attended special N.S.S. camp during B.Sc.4. District level player of Basketball.

TRAINING

Training on electrophysiology and two photon microscopic techniques at NIPIS,Okazaki, JAPAN.

Real Time PCR training at Labindia research and Development Laboratory,Gurgaon,INDIA.

Training on Good Lab Practice by Dr. Sudhir Shirivastava.

CONFERENCES ATTENDED

Participated in Thesis writing workshop held at PGIMER Chandigarh, India. (2011)

Participated in Indo-US comprehensive stroke center training program held at

PGIMER, Chandigarh, India. (2010) Participated in Symposium on Intellectual Property Rights in Biomedical Research

held at PGIMER, Chandigarh, India. (2010)

Participated in National Conference on Tropical Neurology, India. (2009)

Oral presentation in International conference at IAN on Genetic Screening of AgeRelated Macular Degeneration Patients. India (2008)

Presented a poster in National Seminar on Role of Biotechnology in transgenicAnimals. India. (2006)

Presented a poster in Third Madhya Pradesh Science Congress on DNA FingerPrinting. India. (2006)

http://annalsofneurosciences.org/journal/index.php/annal/about/editorialTeamBio/7http://annalsofneurosciences.org/journal/index.php/annal/about/editorialTeamBio/7

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List of Publications in International Journals*

* Number all publications in international journals or book chapters, with earliest first

and most recent at the end. Provide the Impact Factor (IF) of the journal and indicate

your contribution the work described and the publication. Use as many pages as

required. Follow the style in these examples:

1. A. Anand, P. K. Gupta, N. K. Sharma, S. P. Soluble VEGFR1 (sVEGFR1) as a novelmarker of Amyotrophic lateral sclerosis in North Indian ALS patients. European Journal of

Neurology. (2011) (IF 2.5)

N. K. Sharmas contribution to this workwas in statistical analysis and conduction of

experiments.

2. P. K. Gupta, S. Prabhakar, C. Abburi, N. K. Sharma and A. Anand. Vascular endothelial

growth factor-A and chemokine ligand genes are upregulated in peripheral bloodmononuclear cells in Indian amyotrophic lateral sclerosis patients. Journal of

Neuroinflammation 8,114 (2011) (IF 3.8)

N. K. Sharmas contribution to this work was in statistical analysis.

3. P. K. Gupta, S. Prabhakar, N. K. Sharma, A. Anand. Possible Association between

Expression of Chemokine Receptor-2 (CCR2) and Amyotrophic Lateral Sclerosis (ALS)

Patients of North India . Plos One 7, e38382 (2012). (IF 4.4).

N. K. Sharmas contribution to this work was in analysis of data

4.N. K. Sharma, S. Prabhakar, A. Anand. Age related macular degenerationadvances andtrends. Annals of Neurosciences 2, 62-71 (2009).

N. K. Sharmas contribution to this work was in writing the review.

*****************

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Abstract

Indicate below the abstract that is submitted by you for presentation at the YSP and the

FAOBMB Congress in Bangkok (include all authors, affiliation(s) and the text of the

abstract)

Title: Serum levels and polymorphism investigation in CFH loci in agerelated macular degeneration.

Authors: Neel Kamal Sharma,1 Sudesh Prabhakar1, Suresh Sharma2, Amod Gupta3, RamandeepSingh3, Akshay Anand1

1 Department of Neurology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India, 2

Department of Biostatistics, Panjab University, Chandigarh, India. 3 Department of Ophthalmology, Post Graduate Institute

of Medical Education and Research (PGIMER), Chandigarh, India,

Purpose: The purpose of the study was to determine serum complement

factor H (CFH) levels and the association of the CFH gene Y402H

polymorphism in patients with age related macular degeneration (AMD) in

comparison to normal control subjects.

Methods: 115 AMD patients and 61 normal control patients were recruited in

this study. The single neucleotide polymorphism was detected by real time

PCR and serum CFH levels were detected by ELISA and normalize to total

serum protein. Chisquared tests were used for analysis of polymorphism and

t-test for CFH-levels.

Results: The genotype and allele frequencies differed between the AMD

patients (TT18.3%, TC41.3% AND CC40.4%, T39% & C61%) and normal

controls (TT76.3%, TC13.6%, and CC10.2%, T83% & C17%) (p value =

0.0001 & 0.0001 respectively). Levels of serum CFH was significantly lower in

AMD patients as compared to normal controls (p value = 0.001).

Conclusion:Our data confirm that the CFH Y402H polymorphism is a risk

factor for AMD in the North Indian population with a higher frequency of the

Y402 polymorphism in AMD patients and is associated with decreased levelsof CFH protein in AMD patients as compare to normal controls.

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Personal Statement

Indicate briefly here your Research Interests and Career Goals, why you are interested

to participate in the YSP Program (including what you will bring to the YSP and what

you hope to gain from it): (no more than one page)

My research interest is in specializing in the field of age related macular degeneration disease.

My work is based on molecular biology techniques, So I want to enhance my knowledge

about molecular biology techniques and the research work going regarding age related

macular degeneration in the world.

I am interested to participate in the YSP Program because due to conference I can meet with

other scientists working in the same area and can exchange the knowledge, expertise and

information with other organizations. After presentation of my data I can get good comments

from scientists to improve my work. This opportunity will give me chance to publish the data

in conference proceedings.

As many local problems require a global response. I can contribute to the explanation of many

problems and can discuss my research outcomes with scientists from other countries, which

may help them in their study design or experiments. This type of programs provide an

excellent opportunity to develop contacts and network with international organizations

working in same domain of activity.

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