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Cdfgirh K. Xdghdr Givic \dsdireb CilfritfryEdgtdr mfr Ljf/Kfcdeucir Uejdged igh Dgojgddrjgo, _isbjgotfg, HE

5?4 TUI

Mrfk Kuh

tf Dcdetrfhd Eiticysts ighEfghuetjvd Gigfkitdrjics

Hdedkldr 9>, 98

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Dcdetrfhd-orfwg Odflietdr sucmurrdhuedgs ljfmjckJkiod0 Lfgh Cil, Tgjv fm Kjgg

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Odflietdr kdticcjrdhuedgsJkiod0 Cfvcdy Cil, TKiss

Jrfg-\dhuejgo Lietdrji (Md\L)

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Ubj C, dt ic. (9

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Eitbfhd

Igfhd

Ljfdcdetrfebdkjeic Uystdks (LDU)Kjerfljic Dcdetrfebdkjstry/Dcdetrf-Kjerfljfcfoy

Lietdrji odgdritd dcdetrfgs

Lietdrji trigsmdr dcdetrfgs fgtf dcdetrfhds

Ljf-igfhd eig ld i sjgocd spdejds

Igidrflje

Kjerfljic Ljfigfhds Lietdrji efgsukd dcdetrfgs.

Lietdrji gddh eirlfg EF

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ELKUD =.< \dvjdw, @ugd 92, >5

9- 9>ek

Hdptb-hdpdghdgt sdhjkdgt pftdgtjic orihjdgt -

issiy fm kirjgd sdhjkdgt kjerfljic ietjvjty

vs. UBD->.< ] >.= ]witdr

sdhjkdgt

Cjkkfc. Fedigfor.9:=:,98,48?-442

^t kjerfdcdetrfhd

w/jgsucitjgo sbditb

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ELKUD =.< \dvjdw, @ugd 92, >5

Fxyodg0 (EB=(GB5)9=(B^F8) + 952F=EF

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Igfhd

Eitbfhd

RB B++ R-

d-

d-d-

F

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Kirjgd sdhjkdgt &sdiwitdr mrfk i sict

kirsb gdir

Xueadrtfg, Gdw

@drsdy TUI,

5:f 5>.4 G, ?8f9:.=

_.

(4.4% \dhuedh

Eirlfg)

Kirjgd sdhjkdgt &

sdiwitdr mrfk ig

dstuirjgd sjtd wjtbjg

\irjtig Liy, Gdw

@drsdy,8>f

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LKME (Ldgtbje Kjerfljic Mudc Edcc)

mucc systdk jgtdoritjfg0

rdoucitd hjsebirod fm LTO it >.54 ]

efgvdrt >.54 ] tf =]

rdebirod eipiejtfr tf pfwdr \M XR mfr

rdic-tjkd hiti>.>.82 _b/hiy, 9?4

_b/yr, 9> icaicjgd H-edccs/yr)

hjvdr issjstdh hdpcfykdgt

rig mciwcdsscy mfr ? kfgtbs ugtjc jed mcfw

sdvdrdh kffrjgo

@. ^fwdr Ufureds >2, 9?: (

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>

9>

5>

8>

4>

=>

?>

2>

Xueadrtfg ecfgd cjlriry rdsucts

eurrdgtgf eurrdgt

EML Orik+ ftbdr

^dredgtfmecfg

dcjlriry

Dgrjebkdgt jg -sulorfup mrfk

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>

>.9

>..5

>.8

>.4

-4> > 4> 9>> 94> > 5>>

Xjkd (b)

Edccs Iedtitd IYHU

=4 E

Eurrdgt(k

I)

Uejdged I / k.4 ] vs. UBD)

Ljfdcdetrfebdkjeic Uystdks (LDU)Kjerfljic Dcdetrfebdkjsty/Dcdetrf-Kjerfljfcfoy

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Igfhd

Eitbfhd

E=B9

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dxtdrgic

ejreujt

Ie

EF Cz

d-

9> k

igfhd d- 6

O. sucmurrdhuedgs

Lfgh H\, Utryebirz-Ocivdg UK, Xdghdr CK, & Xfrrds EJ (9::-99>4.

Xbd Yudstjfg0

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Kfhdc fm Dxtriedccucir Dcdetrfg Xrigspfrt

edccpjcj

Dxtriedccucir

Eytfebrfkd

(DE)

Dcdetrfg Bfppjgo

\jebtdr B, dt ic. (>:) Eyecje vfctikkdtry fm ljfmjcks fm wjch typd igh kutigt Odflietdr sucmurrdhuedgs fg mudc edcc igfhds jghjeitds

pfssjlcd rfcds fm FkeL, FkeP, typd J] pjcj, igh prftfgs jg dxtriedccucir dcdetrfg trigsmdr. Dgdroy & Dgvjrfgkdgtic Uejdged =-

49=.

Utryebirz UK, dt ic. (99) Ippcjeitjfg fm eyecje vfctikkdtry tf jgvdstjoitd dgbigedh eiticytje eurrdgt odgdritjfg ly ljfmjck-kfhjmjdh

igfhds fm Odflietdr sucmurrdhuedgs strijg HC9 vs. virjigt strijg AG8>>. Dgdroy Dgvjrfg. Uej. 8(5)02:=-:95.

Utryebirz-Ocivdg UK & Xdghdr CK (9=-9992.

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Cfvcdy Cil, TKiss \doudri Cil, KUT

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edccpjcj

Dxtriedccucir

Eytfebrfkd

(DE)

Kittjea, @. U., Xypd J] pjcj igh

twjtebjgo kftjcjty. JgIgguic \dvjdw

fm Kjerfljfcfoy. ]fcukd 4=, >.

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Dxtriedccucir

Eytfebrfkd

(DE)

Kfcdeucir strueturd fm KtrM fm U. fgdjhdgsjsK\-9.

Kfcdeucir ughdrpjggjgos fm Md(JJJ) fxjhd rdhuetjfg

ly Ubdwigdcci fgdjhdgsjsK\-9, Ubj, C. dt ic.,

Mrfgt. Kjerfljfc., 94 Mdlruiry 9< | hfj0

9>.552:/mkjel.9>>4

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Kfhdc fm Dxtriedccucir Dcdetrfg Xrigspfrt

edccpjcj

Dxtriedccucir

Eytfebrfkd

(DE)

Gdrgst Dquitjfg

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Ie/EF>, Uirib K. Utryebirz, Igtbfgy . Kicigfsaj, \iebdc K. Ugjhdr, Bigi Zj, Hdrda \. Cfvcdy igh Cdfgirh K. Xdghdr,

Dgdroy Dgvjrfg. Uej., 99, 8, 2:=-:95

9

rdhfx orihjdgthjmmusjvd DDX

Mjeas 9stCiw0

Hibks-\umm0

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9.8

9.

>.2

>.=

>.8

>..>

\ikigJgtdgsjty,i.u.

9898>>952>95=>958>9595>>

\ikig sbjmt, ek-9

95?995=9

989 kk

kfrd fxjhjzdhz ; > kk

kfrd rdhuedh

dx sjtu

~9 kk spft hjikdtdr

z ; >, 5, =, : kk

kippjgo vjlritjfgic ietjvjty tf tbd bdkd strueturd ly usjgo Hdgsjty Mugetjfgic Xbdfry

Cdldhdv, G.1 Utryebirz-Ocivdg, U. K.1 Xdghdr, C. K., Upitjiccy \dsfcvdh Efgmfeic \dsfgigt \ikig Kjerfsefpje Igicysjs fm Igfhd-Orfwg Odflietdr sucmurrdhuedgs Ljfmjcks. Ebdk^bysEbdk 98, 94 (

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Updetrfsefpje Ucjejgo tf \dvdic Jgtdrgic \dhfx Orihjdgts jg Dcdetrjejty^rfhuejgo Ljfmjcks

Igodwightd Ebdkjd Jgtdrgitjfgic Dhjtjfg

]fcukd 4.9>>/mucc#mjo< jg sjtu

http://onlinelibrary.wiley.com/doi/10.1002/anie.v52.3/issuetochttp://onlinelibrary.wiley.com/doi/10.1002/anie.201205440/fullhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201205440/fullhttp://onlinelibrary.wiley.com/doi/10.1002/anie.201205440/fullhttp://onlinelibrary.wiley.com/doi/10.1002/anie.v52.3/issuetoc

8/10/2019 Leonard Tender Seminar

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Xurgfvdr hurjgo ljfmjck orfwtb

Utryebirz UK, dt ic. (99) Ippcjeitjfg fm eyecje vfctikkdtry tf jgvdstjoitd dgbigedh eiticytje eurrdgt odgdritjfg ly ljfmjck-kfhjmjdh

igfhds fm Odflietdr sucmurrdhuedgs strijg HC9 vs. virjigt strijg AG8>>. Dgdroy Dgvjrfg. Uej. 8(5)02:=-:95.

Hjmmusjvd Ldbivjfr

DE kdebigjsk

Eyecje ]fctikkdtry

Gdrgstjig

Gjebfcsfg & Ubijg

J Hj j h j c h I (JHI)

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84 kk

d- d-d- d-

Dcdetrfhd 9 Dcdetrfhd < Dcdetrfhd 9 Dcdetrfhd .8?4 ]

ippcjdh

Dcdetrfhd .4?4 ]

ippcjdh

Dcdetrfhd 9

Hrijg

->.8?4 ]

ippcjdh

Dcdetrfhd .4?4 ]

ippcjdh

JHI Oitd Dxpdrjkdgts

JHI O t D j t

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Ie/EF