Is bewegen goed voor het brein
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Romain Meeusen PhD Dept. Human Physiology Vrije Universiteit Brussel School Of Public Health, Tropical Medicine & Rehabilitation Sciences, James Cook University, Queensland, Australia
Transcript of Is bewegen goed voor het brein
Romain Meeusen PhD D e p t . H u m a n P h y s i o l o g y V r i j e U n i v e r s i t e i t B r u s s e l
S c h o o l O f P u b l i c H e a l t h , T r o p i c a l M e d i c i n e & R e h a b i l i t a t i o n S c i e n c e s , J a m e s C o o k U n i v e r s i t y ,
Q u e e n s l a n d , A u s t r a l i a
� RCT : 1 yr physical activity or stretching � 2 x 60 subjects � Mean age 65.6 – 67.5yr � 40 min of walking 2-3/Wk or stretching è measuring Brain volume (MRI)
Erickson et al 2011
Hippocampus remains plastic in late adulthood
Erickson et al 2011
Aerobic Fitness è Positive relation
with academic performance
BMI è Negative relation Relevant neural networks è Prefrontal Cortex è Parietal/Posterior
Cingulate Cortex Hillman et al 2008
Associated with aerobic fitness
Chaddock et al 2010
Hillman et al, 2014
� N= 221 � 7-9yr � 9 month intervertion RCT (waiting list) � Measuring Brain Activity - ERP � Accuracy & reaction time (executive control)
Hillman et al, 2014
� Fitness ↑ � Cognitive tests ↑ � Attention ↑ � Cognitive flexibility ↑
� P3 amplitude ↑ for conditions that require great amount of executive control
� Flexibility of Brain Functions
What are the mechanisms ? Animal & Human studies
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Neurogenesis = production of new nerve cells è Important during development ?
Is the most abundant neurotrophin in the brain ègrowth factor within the brain It enhances the growth and maintenance of several neural
systems Serves as a neurotransmitter modulator Participates in use-dependent plasticity mechanisms BDNF expression is diminished in Alzheimer’s disease
Enhances the survival of ‘newborn’ neurons = cell proliferation
Or in neurogenesis (4 weeks old cells) One day 4 weeks
60 min @ 55%Wattmax + TT @ 75% Wattmax
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40
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Rest 60min at 55% TT at 75% Recovery
Serum BDNF (% increase)
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Goekint et al 2008, 2011, Bos et al 2013, 2014
� Depends on the exercise intensity & duration � Exercise increases peripheral BDNF � Dose response to intensity
Torbeyns, Meeusen et al 2014, 2015
� Exercise is good for the Brain � BDNF : most abundant neurotrophin in the
brain � Acute exercise :
¡ Dose response increase � Training : brain changes, learning & memory
