BAKTERI GASTROENTERITIS+HP-UMI-OKTOBER-007

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BAKTERI PENYEBAB GASTROENTRITIS DAN HELICOBACTER PYLORI OLEH : MUHAMMAD ASAAD MAIDIN BAGIAN MIKROBIOLOGI , FAKULTAS KEDOKTERAN UNHAS

Transcript of BAKTERI GASTROENTERITIS+HP-UMI-OKTOBER-007

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BAKTERI PENYEBAB

GASTROENTRITIS DAN

HELICOBACTER PYLORI

OLEH :

MUHAMMAD ASAAD MAIDIN

BAGIAN MIKROBIOLOGI, FAKULTAS

KEDOKTERAN UNHAS

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  Enterohemorrhagic

( EHEC, VTEC )

Enteroadherent ( EAEC )

Shigella dysentriae, S.flexnery, S.boydii, S.sonnei

Salmonella typhi

Salmonella enteritidis*

Vibrionaceae

Vibrio cholerae

Vibrio Parahaemolyticus

Campylobacter andHelicobacter

Campylobacter fetus,C.jejuni

Helicobacter pylori

Human carriers,possibly catle

Human carriers

Human GI tract

Human GI tract

Cattle, poultry

Human GI tractSeawater, seafood

Animals, humancarriers

Unknown

Diarrhea, hemorrhagiccolitis, hemolytic-uremicsyndrome

Diarrhea

Dysentery, diarrhea

Typhoid fever,bacteremia

Gastroenteritis

Profuse, watery diarrhea

Watery diarrhea

Diarrhea, septicemia

Chronic gastritis, peptic,ulecer, gastric cancer

EAEC=enterodherent E.coli; EHEC=enterohemorrhagie; ETEC= enterotoxigenic; E.coli; G1=gastrointestinal;

VTEC= verotoxin-producing E.coli. S. enteritidis is subclassified into hundreds of serotypes

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Gastrointestinal

Urinary tract infections

Klebsiella pneumoniae

Pseudomonas aeruginosa

Staphylococcus aureusAnaerobic bacteria

Vibrio cholerae

Vibrio parahaemolyticus

Escherichia coli

Salmonella species *

Shigella speciesCampylobacter species

Helicobacter pylori

Clostridium perfringens

Clostridium difficile

Bacillus cereusEscherichia coli

Pseudomonas aeruginosa

Enterobacter species

Kl;ebsiella species

Proteus species

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Table 52-1. Noninvasive Versus Invasive Diarrhea

Noninvasive Invasive ( Bacterial / Parasitic )

Stool Profuse secretory Dysentery

(blood,mucus,PMN lukocytes( Severe, watery )

Fever No YesSystemic No YesAbdominal pain Mild Severe ( carmping, tenesmus )

Site of infection Small intestine Colon

PMN = polymorphonucleaR

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Tabel 52.2 . Features of specific Types of Noninvasive Bacterialdiarrhea

VibrioCholerae

Escherichiacoli

Clostridium

prefringens

Bacilluscereus*

Staphylococcus aureus+

Incubation( hours )

Duration( Housr )

Abdominalcramps

Vomiting

12 – 72

48 – 120

0

+

24 – 72

24 – 48

+

± 

6 – 12

12 – 24

++++

+

3 – 8

12 – 24

++

++

1 – 6

6 – 12

++

++++

•Diarrhea can be caused by performed toxin or by toxin elaborated in the intestine by proliferating bacteria

+ Diarrhea can be caused by ingestion of toxin  –  contaminated food

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Table 52-3. Features of Specific Types of InvasiveBacterial Diarrhea

Shigella Escherich i coli

Salmonella Yersiniaenterocoliti ca

Incubation( hours )

Duartion(hours)

Abdominal

pain

Vomiting

Fever

24 – 72

48 – 120

++++

++

++

24 – 72

24 – 48

++++

+

++

8 – 48

12 – 24

+

+

++++

1 – 6

6 – 12

++

++

++

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Table 52-4. Clinical and Epidemiological Features of Bacterial FoodPoisoning

Cause

Percentageof Reported

Outbreaks

Incubation Period

( hours )

ClinicalPresentation

CharacteristicFoods

Intoxication

Bacillus cereus

Clostridium

botolinum

Staphylococcus

aureus

Vibrio

parahaemolyticus

Infections

Bacillus cereus

clostridium

perfringens

Salmonella

Shigella

1 – 2

5 – 15

15 – 25

1 – 2

1 – 2

5 – 15

10 – 30

2 – 5

1 – 6

12 – 27

2 – 4

10 24

6 – 24

9 – 15

6 – 48

12 – 48

Vomiting

Neuromuscular

Paralysis

Vomitingdiarrhea

Watery diarrhea

Watery diarrhea

Watery diarrhea

Dysentery

Dysentery

Re-warmed friedrice

Canned foods of alltypes

Metas, custrad,Salads

Shellfish

Meat, poultry,vegetables

Meat, poultry

Poultry, eggs, meat,

vegetables

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HELICOBACTER PYLORI

# Spiral shaped or curved negative gramrod similar in appearance to

campylobacters, but differ sufficiently in

certain biochemical and flagellar

characteristics.

• # Motile active

# On media skirrow or cocolate medium,growing with in 3-6 hari, 37’C,

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• # microaerofilic.

• # Oxidase positive

• # Catalase positive

• # Strongly urease positive

(Campylobacter urease negative)

• # Flagella positive

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• The environment found in the mucous

layer of the gut, a transitional zonebetween the anaerobic lumen and theoxygenated mucosa

•Size 3.5x o,6 um, with 1.5 wave lengthsand 4 to 7 sheated flagella at one endof the organism.

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• HP causes gastritis and peptic ulcer.

Infection with HP is a risk factor forgastric carcinoma.

• Transmission : person to personbecause there is clustering with infamilies.

• Laboratory diagnosis:

= Gram stained smears(endoscopy orbiopsy)

=

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