Alignment 195 Vert PTP Domainsptp.cshl.edu/downloads/ptp_alignment_files/...VectorNTI Screen View -...

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VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr Section 1 1 118 10 20 30 40 50 60 70 80 90 100 (1) A D M A E H T E R L K A N D S - - - - - - L K L S Q E Y E S I D P G - - - - Q Q F T W E H - - - S N L E V N K P K - N R Y A N V I A Y D H S R V I L Q P I E G I - - - - - - - - - - - - - - - - - - - - - M G S D Y I N A N Y V D G Y R R Q hPTPsigma_D1 (NP_002841) PTPRS (1) T D M A E H M E R L K A N D S - - - - - - L K L S Q E Y E S I D P G - - - - Q Q F T W E H - - - S N L E A N K P K - N R Y A N V I A Y D H S R V I L Q P L E G I - - - - - - - - - - - - - - - - - - - - - M G S D Y I N A N Y V D G Y R R Q mPTPsigma_D1 (NP_035348(revised)) Ptprs (1) T D M A E H M E R L K A N D S - - - - - - L K L S Q E Y E S I D P G - - - - Q Q F T W E H - - - S N L E A N K P K - N R Y A N V I A Y D H S R V I L Q P L E G I - - - - - - - - - - - - - - - - - - - - - M G S D Y I N A N Y V D G Y R R Q rPTPsigma_D1 (NP_062013) Ptprd (1) S E L A E H T E H L K A N D N - - - - - - L K L S Q E Y E S I D P G - - - - Q Q F T W E H - - - S N L E V N K P K - N R Y A N V I A Y D H S R V I L L P I E G I - - - - - - - - - - - - - - - - - - - - - V G S D Y I N A N Y I D G Y R K Q cPTPsigma_D1 (I50212) (1) A D L A E H T E H L K A N D N - - - - - - L K L S Q E Y E S V D P G - - - - Q Q F T W E H - - - S N L E V N K A K - N R Y A N V I A Y D H S R V I L L P V E G I - - - - - - - - - - - - - - - - - - - - - I G S D Y I N A N Y I D G Y R K Q xPTPsigma_D1 (AAF43607) (1) S E L A E H T E L L K A N D N - - - - - - L K L S Q E Y E S I D P G - - - - Q Q F T W E H - - - S N L E V N K P K - N R Y A N V I A Y D H S R V I L A P I E G I - - - - - - - - - - - - - - - - - - - - - T G S D Y I N S N Y I D G Y R K Q zPTPsigma_D1 (CAC44759) (1) T D L A D N I E R L K A N D G - - - - - - L K F S Q E Y E S I D P G - - - - Q Q F T W E N - - - S N L E V N K P K - N R Y A N V I A Y D H S R V I L T S I D G V - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A N Y I D G Y R K Q hLAR_D1 (NP_002831) PTPRF (1) T D L A D N I E R L K A N D G - - - - - - L K F S Q E Y E S I D P G - - - - Q Q F T W E N - - - S N S E V N K P K - N R Y A D V I A Y D H S R V L L T S I D G V - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A N Y I D G Y R K Q mLAR_D1 (NP_035343) Ptprf (1) T D L A D N I E R L K A N D G - - - - - - L K F S Q E Y E S I D P G - - - - Q Q F T W E N - - - S N S E V N K P K - N R Y A N V I A Y D H S R V L L T S I D G V - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A N Y I D G Y R K Q rLAR_D1 (NP_062122) Ptprf (1) S D L A D N I E R L K A N D G - - - - - - L K F S Q E Y E S I D P G - - - - Q Q F T W E N - - - S N L E V N K P K - N R Y A N V I A Y D H S R V I L T S V D A V - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A N Y I D G Y R K Q xLAR_D1 (AAF43606) (1) L E L A D H I E R L K A N D N - - - - - - L K F S Q E Y E S I D P G - - - - Q Q F T W E H - - - S N L E V N K P K - N R Y A N V I A Y D H S R V L L S A I E G I - - - - - - - - - - - - - - - - - - - - - P G S D Y V N A N Y I D G Y R K Q hPTPdelta _D1 (NP_002830) PTPRD (1) L E L A D H I E R L K A N D N - - - - - - L K F S Q E Y E S I D P G - - - - Q Q F T W E H - - - S N L E V N K P K - N R Y A N V I A Y D H S R V L L S A I E G I - - - - - - - - - - - - - - - - - - - - - P G S D Y V N A N Y I D G Y R K Q mPTPdelta_D1 (D54689) (1) L E L E D H I E R L K A N D N - - - - - - L K F S Q E Y E S I D P G - - - - Q Q F T W E H - - - S N L E V N K P K - N R Y A N V I A Y D H S R V L L S A I D G I - - - - - - - - - - - - - - - - - - - - - P G S D Y I N S N Y I D G Y R K Q xPTPdelta_D1 (AAF43605) (1) A D L L Q H I T Q M K R G Q G - - - - - - Y G F K E E Y E A L P E G - - - - Q T A S W D T - - - A K E D E N R N K - N R Y G N I I S Y D H S R V R L L V L D G D - - - - - - - - - - - - - - - - - - - - - P H S D Y I N A N Y I D G Y H R P hPTPrho_D1 (NP_573400) PTPRT (1) A D L L Q H I T Q M K R G Q G - - - - - - Y G F K E E Y E A L P E G - - - - Q T A S W D T - - - A K E D E N R N K - N R Y G N I I S Y D H S R V R L L V L D G D - - - - - - - - - - - - - - - - - - - - - P H S D Y I N A N Y I D G Y H R P mPTPrho_D1 (NP_067439) Ptprt (1) A D L L Q H I T Q M K R G Q G - - - - - - Y G F K E E Y E A L P E G - - - - Q T A S W D T - - - A K E D E N R N K - N R Y G N I I S Y D H S R V R L Q Q I E E D - - - - - - - - - - - - - - - - - - - - - P H S D Y I N A N Y V D G Y H R P xPTPrho_D1 (AAD50295) (1) A D L L Q H I T Q M K C A E G - - - - - - Y G F K E E Y E S F F E G - - - - Q S A P W D S - - - A K K D E N R M K - N R Y G N I I A Y D H S R V R L Q T I E G D - - - - - - - - - - - - - - - - - - - - - T N S D Y I N G N Y I D G Y H R P hPTPmu_D1 (NP_002836) PTPRM (1) A D L L Q H I T Q M K C A E G - - - - - - Y G F K E E Y E S F F E G - - - - Q S A P W D S - - - A K K D E N R M K - N R Y G N I I A Y D H S R V R L Q M L E G D - - - - - - - - - - - - - - - - - - - - - N N S D Y I N G N Y I D G Y H R P mPTPmu_D1 (NP_033010) Ptprm (1) A D L L Q H I N L M K T S D S - - - - - - Y G F K E E Y E S F F E G - - - - Q S A S W D V - - - A K K D Q N R A K - N R Y G N I I A Y D H S R V I L Q P V E D D - - - - - - - - - - - - - - - - - - - - - P S S D Y I N A N Y I D G Y Q R P hPTPkappa_D1 (NP_002835) PTPRK (1) A D L L Q H I N L M K T S D S - - - - - - Y G F K E E Y E S F F E G - - - - Q S A S W D V - - - A K K D Q N R A K - N R Y G N I I A Y D H S R V I L Q P V E D D - - - - - - - - - - - - - - - - - - - - - P S S D Y I N A N Y R D G Y Q R P mPTPkappa_D1 (NP_033009 (revised)) Ptprk (1) A D L L Q H I N Q M K T A E G - - - - - - Y G F K Q E Y E S F F E G - - - - - - - - W D - - - - A T K K K D K V K G S R Q E P M P A Y D R H R V K L H P M L G D - - - - - - - - - - - - - - - - - - - - - P N A D Y I N A N Y I D G Y H R S hPTPlamda_D1 (NP_005695) PTPRU (1) A D L L Q H I N Q M K T A E G - - - - - - Y G F K Q E Y E S F F E G - - - - - - - - W D - - - - A T K K K D K L K G G R Q E P V S A Y D R H H V K L H P M L A D - - - - - - - - - - - - - - - - - - - - - P D A D Y I S A N Y I D G Y H R S mPTPlamda_D1 (NP_035344) Ptprl (1) A D L L Q H I N Q M K T A E G - - - - - - Y G F K Q E Y E S F F E G - - - - - - - - W D - - - - A T K K K D K L K S G R Q E P V S A Y D R H R V K L H P M L G D - - - - - - - - - - - - - - - - - - - - - P D A D Y I S A N Y I D G Y H R P rPTPpsi_D1 (AAB42210) Ptpru Fragm (1) D K L E E E I N R R I G D D N - - - - - - K L F R E E F N A L P - - - - - - A C P I Q A T C E A A S K E E N K E K - N R Y V N I L P Y D H S R V H L T P V E G V - - - - - - - - - - - - - - - - - - - - - P D S H Y I N T S F I N S Y Q E K cPTPalpha_D1 (AAB04150) (1) D K L E E E I N R R M A D D N - - - - - - K L F R E E F N A L P - - - - - - A C P I Q A T C E A A S K E E N K E K - N R Y V N I L P Y D H S R V H L T P V E G V - - - - - - - - - - - - - - - - - - - - - P D S D Y I N A S F I N G Y Q E K hPTPalpha_D1 (NP_002827) PTPRA (1) D K L E E E I N R R M A D D N - - - - - - K L F R E E F N A L P - - - - - - A C P I Q A T C E A A S K E E N K E K - N R Y V N I L P Y D H S R V H L T P V E G V - - - - - - - - - - - - - - - - - - - - - P D S D Y I N A S F I N G Y Q E K mPTPalpha_D1 (AAK56109) Ptpra (1) D K L E E E I N R R M A D D N - - - - - - K L F R E E F N A L P - - - - - - A C P I Q A T C E A A S K E E N K E K - N R Y V N L L P Y D H S R V H L T P V E G V - - - - - - - - - - - - - - - - - - - - - P D S D Y I N A S F I N G Y Q E K rPTPalpha_D1 (NP_036895) Ptpra (1) D K L E E E M N R R M A D D N - - - - - - K L F R E E F N A L P - - - - - - V C P I Q A S C D A A S K E E S K E K - N R Y V N I L P Y D H S R V H L T S L E G V - - - - - - - - - - - - - - - - - - - - - P D S D Y I N A S Y I N G Y Q E K zPTPalpha_D1 (NP_571963) ptpra (1) D K L E E E I N R R M A D D N - - - - - - K L F R E E S N A L P - - - - - - A C P I Q A T C E A A S K E E N M E K - N R Y V N I L P Y D H S R V H L S P I E G V - - - - - - - - - - - - - - - - - - - - - P D S D Y I N S S F I N G Y Q E K xPTPalpha_D1 (AAA17990) (1) E H L E E E I R I R S A D D C - - - - - - K Q F R E E F N S L P - - - - - - S G H I Q G T F E L A N K E E N R E K - N R Y P N I L P N D H S R V I L S Q L D G I - - - - - - - - - - - - - - - - - - - - - P C S D Y I N A S Y I D G Y K E K hPTPepsilon_D1 (NP_006495) PTPRE (1) E H L E E E I R V R S A D D C - - - - - - K R F R E E F N S L P - - - - - - S G H I Q G T F E L A N K E E N R E K - N R Y P N I L P N D H C R V I L S Q V D G I - - - - - - - - - - - - - - - - - - - - - P C S D Y I N A S Y I D G Y K E K mPTPepsilon_D1 (NP_035342) Ptpre (1) E H L E E E I R V R S A D D C - - - - - - K R F R E E F N S L P - - - - - - S G H I Q G T F E L A N K E E N R E K - N R Y P N I L P N D H C R V I L S Q L D G I - - - - - - - - - - - - - - - - - - - - - P C S D Y I N A S Y I D G Y K E K rPTPepsilon_D1 (XP_215102) Ptpre (1) K Q F V K H I G E L Y S N N Q - - - - - - H G F S E D F E E V Q R C - - - - T A D M N I T A E H S N H P E N K H K - N R Y I N I L A Y D H S R V K L R P L P G K D S - - - - - - - - - - - - - - - - - - - K H S D Y I N A N Y V D G Y N K A hPTPgamma_D1 (NP_002832) PTPRG (1) K Q F G K H I G E L Y S N S Q - - - - - - H G F S E D F E E V Q R C - - - - T A D M N I T A E H S N H P D N K H K - N R Y I N I L A Y D H S R V K L R P L P G K D S - - - - - - - - - - - - - - - - - - - K H S D Y I N A N Y V D G Y N K A mPTPgamma_D1 (NP_033007) Ptprg (1) I P I P D D M E A I P V K Q F - - G K S Q H G F S G D F E E V Q R C - - - - T A D M N I T A E H S N H P D N K H K - N R Y I N I L A Y D H S R V K L R P L P G K D S - - - - - - - - - - - - - - - - - - - K H S D Y I N A N Y V D G Y N K A rPTPgamma _D1 (NP_599183) Ptprg (1) K Q F V K H I S E L Y S N N Q - - - - - - H G F S E D F E E V Q R C - - - - T A D M N I T A E H S N H P D N K H K - N R Y I N I L A Y D H S R V K L R P L P G K D S - - - - - - - - - - - - - - - - - - - K H S D Y I N A N Y V S G Y N K A cPTPgamma_D1 (Q98936) (1) K H F P K H V A D L H A S S G - F T E E F E T L K E F Y Q E V Q S C - - - - T V D L G I T A D S S N H P D N K H K - N R Y I N I V A Y D H S R V K L A Q L A E K D G - - - - - - - - - - - - - - - - - - - K L T D Y I N A N Y V D G Y N R P hPTPzeta_D1 (NP_002842) PTPRZ1 (1) K H F P K H V A D L H A S N G - F T E E F E T L K E F Y Q E V Q S C - - - - T V D L G I T A D S S N H P D N K H K - N R Y V N I V A Y D H S R V K L T Q L A E K D G - - - - - - - - - - - - - - - - - - - K L T D Y I N A N Y V D G Y N R P rPTPzeta_D1 (NP_037212) Ptprz1 (1) K H F P K H V A D L H A S N G - - - - - - - - F S E E F E E I Q S C - - - - T V D L G I T S D S S N H P D N K N K - N R Y I N I V A Y D H T R V K L A Q L A E K D G - - - - - - - - - - - - - - - - - - - K L T D Y I N A N Y V D G Y N K P cPTPzeta_D1 (AAA49015) (1) K Q F H K H V E D L H S R N G - - - - - - - - F T D E F E E V Q N C - - - - T T D L G I T Y E N S N H P D N K N K - N R Y I N I V A Y D H S R V K L S Q L A E K D G - - - - - - - - - - - - - - - - - - - K A T D Y I N A N F V D G Y N K Q xPTPzeta_D1 (BAA97445) (1) D I L L E T Y K R K I A D E G - - - - - - R L F L A E F Q S I P - - - - - - R V F S K F P I K E A R K P F N Q N K - N R Y V D I L P Y D Y N R V E L S E I N G D - - - - - - - - - - - - - - - - - - - - - A G S N Y I N A S Y I D G F K E P hCD45_D1 (NP_002829) PTPRC (1) D I L L E T Y K R K I A D E G - - - - - - R L F L A E F Q S I P - - - - - - R V F S K F P I K D A R K P H N Q N K - N R Y V D I L P Y D Y N R V E L S E I N G D - - - - - - - - - - - - - - - - - - - - - A G S T Y I N A S Y I D G F K E P mCD45_D1 (NP_035340) Ptprc (1) D L L L E T Y K R K I A D E G - - - - - - R L F L A E F Q S I P - - - - - - R V F S K F P I K D A R K S Q N Q N K - N R Y V D I L P Y D Y N R V E L S E I N G D - - - - - - - - - - - - - - - - - - - - - A G S T Y I N A S Y I D G F K E P rCD45_D1 (XP_213985) Ptprc (1) E K L L E T Y K R K I A D E G - - - - - - R L F L D E F Q S I P - - - - - - R I F T K F P M K E A K R S H N Q N K - N R Y I D I L P Y D H N R V E L S E I P G D - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A S Y I D G F K E P cCD45_D1 (A54080) (1) G G L V E A Y K N K I A D E G - - - - - - R L F M D E F Q S I P - - - - - - R I F S N Y T I K E A K K S E N Q Y K - N R Y V D I L P Y D Y N R V T L S T G G E D - - - - - - - - - - - - - - - - - - - - - - - - N Y I N A S F I E G Y R E P cypcaCD45_D1 (BAA92179) (1) E T L L D A Y K R K I A D E G - - - - - - R L F L A E F Q S I P - - - - - - R I F S K Y T V K E A K K S H N V P K - N R Y V D I L P Y D Y N R V Q L T T G N G S - - - - - - - - - - - - - - - - - - - - - A G C D Y I N A S F I D G F K E L fuCD45_D1 (CAB96211) (1) E Q L I D V Y R R K Q A D E S - - - - - - R L F L A E F Q S I P - - - - - - R V F S K F S V K E A R R G C N T N K - N R Y V D I L P Y D H N R V Q L S P I A G E - - - - - - - - - - - - - - - - - - - - - Q G S D Y I N A S F I D G F N E S sharkCD45_D1 (T43148) (1) E N F E A Y F K K Q Q A D S N - - - - - - C G F A E E Y E D L K - - - - - - L V G I S Q P K Y A A E L A E N R G K - N R Y N N V L P Y D I S R V K L S V Q T H S - - - - - - - - - - - - - - - - - - - - - - T D D Y I N A N Y M P G Y H S K hDEP1_D1 (NP_002834) PTPRJ (1) E N F E A Y F K K Q Q A D S N - - - - - - C G F A E E Y E D L K - - - - - - L I G I S L P K Y A A E I A E N R G K - N R Y N N V L P Y D I S R V K L S V Q T H S - - - - - - - - - - - - - - - - - - - - - - T D D Y I N A N Y M P G Y H S K rDEP1_D1 (NP_058965) Ptprj (1) E N F E A Y F K K Q Q A D S N - - - - - - C G F A E E Y E D L K - - - - - - L I G I S L P K Y T A E I A E N R G K - N R Y N N V L P Y D I S R V K L S V Q T H S - - - - - - - - - - - - - - - - - - - - - - T D D Y I N A N Y M P G Y H S K mDEP1_D1 (NP_033008) Ptprj (1) D D F D A Y I K D M A K D S D - - - - - - Y K F S L Q F E E L K - - - - - - L I G L D I P H F A A D L P L N R C K - N R Y T N I L P Y D F S R V R L V S M N E E - - - - - - - - - - - - - - - - - - - - - E G A D Y I N A N Y I P G Y N S P hGLEPP1_D1 (NP_109592) PTPRO (1) D D F D S Y I K D M A K D S D - - - - - - Y K F S L Q F E E L K - - - - - - L I G L D I P H F A A D L P L N R C K - N R Y T N I L P Y D F S R V R L V S M N E E - - - - - - - - - - - - - - - - - - - - - E G A D Y I N A N Y I P G Y N S P rGLEPP1_D1 (NP_059032) Ptpro (1) D D F D S Y I K D M A K D S D - - - - - - Y K F S L Q F E E L K - - - - - - L I G L D I P H F A A D L P L N R C K - N R Y T N I L P Y D F S R V R L V S M N E E - - - - - - - - - - - - - - - - - - - - - E G A D Y I N A N Y I P G Y N S P mPTPphi_D1 (NP_035346) Ptpro (1) D D F D A Y I K D M A K D S D - - - - - - Y K F S L Q F E E L K - - - - - - L I G L D I P H F A A D L P L N R C K - N R Y T N I L P Y D F S R V R L L S M N E E - - - - - - - - - - - - - - - - - - - - - E G A D Y I N A N Y I P G Y N S P rabPTPoc_D1 (AAB16824) (1) N Q F E G H F M K L Q A D S N - - - - - - Y L L S K E Y E E L K - - - - - - D V G R N Q S C D I A L L P E N R G K - N R Y N N I L P Y D A T R V K L S N V D D D - - - - - - - - - - - - - - - - - - - - - P C S D Y I N A S Y I P G N N F R hPTPbeta_D1 (NP_002828) PTPRB (1) N Q F E G H F M K L Q A D S N - - - - - - Y L L S K E Y E D L K - - - - - - D V G R S Q S C D I A L L P E N R G K - N R Y N N I L P Y D A S R V K L S N V D D D - - - - - - - - - - - - - - - - - - - - - P C S D Y I N A S Y I P G N N F R mPTPbeta_D1 (NP_084204) Ptprb (1) N Q F E G H F M K L Q A D S N - - - - - - Y L L S K E Y E D L K - - - - - - D V G R S Q S C D I A L L P E N R G K - N R Y N N I L P Y D A S R V K L C N V D D D - - - - - - - - - - - - - - - - - - - - - P C S D Y I N A S Y I P G N N F R rPTPbeta_D1 (XP_235156 (revised)) (1) K S F L Q H V E E L C T N N N - - - - - - L K F Q E E F S E L P - - - - - - K F L Q D L S S T D A D L P W N R A K - N R F P N I K P Y N N N R V K L I A D A S V - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A S Y I S G Y L C P hPTPS31_D1 (AR073855) PTPGMC1 (1) K S F L Q H V E E L C T N S N - - - - - - L K F Q E E F S E L P - - - - - - K F L Q D L S S T D A D L P W N R A K - N R F P N I K P Y N N N R V K L I A D V S L - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A S Y V S G Y L C P rPTPGMC1_D1 (NP_075214) Ptprq (1) E D F A D H V R K N E R D S N - - - - - - C G F A D E Y Q Q L S - - - - - - L V G H S Q S Q M V A S A S E N N A K - N R Y R N V L P Y D W S R V P L K P I H E E - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A S F M P G L W S P hSAP1_D1 (NP_002833) PTPRH (1) K D F A D H V R E N E K D S N - - - - - - C G F A E E Y Q Q L A - - - - - - L E G Q G Q S Q I T A S A L E N R S K - N R Y R N V L P Y D W S R V P L Q P L Q E E - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A S F M P G L W S P mSAP1_D1 (BAC37443) (1) K D F A D H V R E N E K D S N - - - - - - C G F A E E Y Q Q L A - - - - - - L E G Q G Q S Q M T A L A L E N V S K - N R Y R N V L P Y D W S R V P L Q P L H E E - - - - - - - - - - - - - - - - - - - - - P G S D Y I N A S F M P G L W S P rPTPBEM2_D1 (NP_598276) (1) H S F R Q S Y E A K S A R A H - - - - - - Q A F F Q E F E E L K - - - - - - E V G K D Q P R L E A E H P A N I T K - N R Y P H V L P Y D H S R V R L T Q L S G E - - - - - - - - - - - - - - - - - - - - - P H S D Y I N A N F I P G Y S H P mPTPESP_D1 (NP_031981) Esp (1) http://ptp.cshl.edu or http://science.novonordisk.com/ptp

Transcript of Alignment 195 Vert PTP Domainsptp.cshl.edu/downloads/ptp_alignment_files/...VectorNTI Screen View -...

Page 1: Alignment 195 Vert PTP Domainsptp.cshl.edu/downloads/ptp_alignment_files/...VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

Section 11 11810 20 30 40 50 60 70 80 90 100(1) ADMAEHTERLKANDS------LKLSQEYESIDPG----QQFTWEH---SNLEVNKPK-NRYANVIAYDHSRVILQPIEGI---------------------MGSDYINANYVDGYRRQhPTPsigma_D1 (NP_002841) PTPRS (1) TDMAEHMERLKANDS------LKLSQEYESIDPG----QQFTWEH---SNLEANKPK-NRYANVIAYDHSRVILQPLEGI---------------------MGSDYINANYVDGYRRQmPTPsigma_D1 (NP_035348(revised)) Ptprs (1) TDMAEHMERLKANDS------LKLSQEYESIDPG----QQFTWEH---SNLEANKPK-NRYANVIAYDHSRVILQPLEGI---------------------MGSDYINANYVDGYRRQrPTPsigma_D1 (NP_062013) Ptprd (1) SELAEHTEHLKANDN------LKLSQEYESIDPG----QQFTWEH---SNLEVNKPK-NRYANVIAYDHSRVILLPIEGI---------------------VGSDYINANYIDGYRKQcPTPsigma_D1 (I50212) (1) ADLAEHTEHLKANDN------LKLSQEYESVDPG----QQFTWEH---SNLEVNKAK-NRYANVIAYDHSRVILLPVEGI---------------------IGSDYINANYIDGYRKQxPTPsigma_D1 (AAF43607) (1) SELAEHTELLKANDN------LKLSQEYESIDPG----QQFTWEH---SNLEVNKPK-NRYANVIAYDHSRVILAPIEGI---------------------TGSDYINSNYIDGYRKQzPTPsigma_D1 (CAC44759) (1) TDLADNIERLKANDG------LKFSQEYESIDPG----QQFTWEN---SNLEVNKPK-NRYANVIAYDHSRVILTSIDGV---------------------PGSDYINANYIDGYRKQhLAR_D1 (NP_002831) PTPRF (1) TDLADNIERLKANDG------LKFSQEYESIDPG----QQFTWEN---SNSEVNKPK-NRYADVIAYDHSRVLLTSIDGV---------------------PGSDYINANYIDGYRKQmLAR_D1 (NP_035343) Ptprf (1) TDLADNIERLKANDG------LKFSQEYESIDPG----QQFTWEN---SNSEVNKPK-NRYANVIAYDHSRVLLTSIDGV---------------------PGSDYINANYIDGYRKQrLAR_D1 (NP_062122) Ptprf (1) SDLADNIERLKANDG------LKFSQEYESIDPG----QQFTWEN---SNLEVNKPK-NRYANVIAYDHSRVILTSVDAV---------------------PGSDYINANYIDGYRKQxLAR_D1 (AAF43606) (1) LELADHIERLKANDN------LKFSQEYESIDPG----QQFTWEH---SNLEVNKPK-NRYANVIAYDHSRVLLSAIEGI---------------------PGSDYVNANYIDGYRKQhPTPdelta _D1 (NP_002830) PTPRD (1) LELADHIERLKANDN------LKFSQEYESIDPG----QQFTWEH---SNLEVNKPK-NRYANVIAYDHSRVLLSAIEGI---------------------PGSDYVNANYIDGYRKQmPTPdelta_D1 (D54689) (1) LELEDHIERLKANDN------LKFSQEYESIDPG----QQFTWEH---SNLEVNKPK-NRYANVIAYDHSRVLLSAIDGI---------------------PGSDYINSNYIDGYRKQxPTPdelta_D1 (AAF43605) (1) ADLLQHITQMKRGQG------YGFKEEYEALPEG----QTASWDT---AKEDENRNK-NRYGNIISYDHSRVRLLVLDGD---------------------PHSDYINANYIDGYHRPhPTPrho_D1 (NP_573400) PTPRT (1) ADLLQHITQMKRGQG------YGFKEEYEALPEG----QTASWDT---AKEDENRNK-NRYGNIISYDHSRVRLLVLDGD---------------------PHSDYINANYIDGYHRPmPTPrho_D1 (NP_067439) Ptprt (1) ADLLQHITQMKRGQG------YGFKEEYEALPEG----QTASWDT---AKEDENRNK-NRYGNIISYDHSRVRLQQIEED---------------------PHSDYINANYVDGYHRPxPTPrho_D1 (AAD50295) (1) ADLLQHITQMKCAEG------YGFKEEYESFFEG----QSAPWDS---AKKDENRMK-NRYGNIIAYDHSRVRLQTIEGD---------------------TNSDYINGNYIDGYHRPhPTPmu_D1 (NP_002836) PTPRM (1) ADLLQHITQMKCAEG------YGFKEEYESFFEG----QSAPWDS---AKKDENRMK-NRYGNIIAYDHSRVRLQMLEGD---------------------NNSDYINGNYIDGYHRPmPTPmu_D1 (NP_033010) Ptprm (1) ADLLQHINLMKTSDS------YGFKEEYESFFEG----QSASWDV---AKKDQNRAK-NRYGNIIAYDHSRVILQPVEDD---------------------PSSDYINANYIDGYQRPhPTPkappa_D1 (NP_002835) PTPRK (1) ADLLQHINLMKTSDS------YGFKEEYESFFEG----QSASWDV---AKKDQNRAK-NRYGNIIAYDHSRVILQPVEDD---------------------PSSDYINANYRDGYQRPmPTPkappa_D1 (NP_033009 (revised)) Ptprk (1) ADLLQHINQMKTAEG------YGFKQEYESFFEG--------WD----ATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGD---------------------PNADYINANYIDGYHRShPTPlamda_D1 (NP_005695) PTPRU (1) ADLLQHINQMKTAEG------YGFKQEYESFFEG--------WD----ATKKKDKLKGGRQEPVSAYDRHHVKLHPMLAD---------------------PDADYISANYIDGYHRSmPTPlamda_D1 (NP_035344) Ptprl (1) ADLLQHINQMKTAEG------YGFKQEYESFFEG--------WD----ATKKKDKLKSGRQEPVSAYDRHRVKLHPMLGD---------------------PDADYISANYIDGYHRPrPTPpsi_D1 (AAB42210) Ptpru Fragm (1) DKLEEEINRRIGDDN------KLFREEFNALP------ACPIQATCEAASKEENKEK-NRYVNILPYDHSRVHLTPVEGV---------------------PDSHYINTSFINSYQEKcPTPalpha_D1 (AAB04150) (1) DKLEEEINRRMADDN------KLFREEFNALP------ACPIQATCEAASKEENKEK-NRYVNILPYDHSRVHLTPVEGV---------------------PDSDYINASFINGYQEKhPTPalpha_D1 (NP_002827) PTPRA (1) DKLEEEINRRMADDN------KLFREEFNALP------ACPIQATCEAASKEENKEK-NRYVNILPYDHSRVHLTPVEGV---------------------PDSDYINASFINGYQEKmPTPalpha_D1 (AAK56109) Ptpra (1) DKLEEEINRRMADDN------KLFREEFNALP------ACPIQATCEAASKEENKEK-NRYVNLLPYDHSRVHLTPVEGV---------------------PDSDYINASFINGYQEKrPTPalpha_D1 (NP_036895) Ptpra (1) DKLEEEMNRRMADDN------KLFREEFNALP------VCPIQASCDAASKEESKEK-NRYVNILPYDHSRVHLTSLEGV---------------------PDSDYINASYINGYQEKzPTPalpha_D1 (NP_571963) ptpra (1) DKLEEEINRRMADDN------KLFREESNALP------ACPIQATCEAASKEENMEK-NRYVNILPYDHSRVHLSPIEGV---------------------PDSDYINSSFINGYQEKxPTPalpha_D1 (AAA17990) (1) EHLEEEIRIRSADDC------KQFREEFNSLP------SGHIQGTFELANKEENREK-NRYPNILPNDHSRVILSQLDGI---------------------PCSDYINASYIDGYKEKhPTPepsilon_D1 (NP_006495) PTPRE (1) EHLEEEIRVRSADDC------KRFREEFNSLP------SGHIQGTFELANKEENREK-NRYPNILPNDHCRVILSQVDGI---------------------PCSDYINASYIDGYKEKmPTPepsilon_D1 (NP_035342) Ptpre (1) EHLEEEIRVRSADDC------KRFREEFNSLP------SGHIQGTFELANKEENREK-NRYPNILPNDHCRVILSQLDGI---------------------PCSDYINASYIDGYKEKrPTPepsilon_D1 (XP_215102) Ptpre (1) KQFVKHIGELYSNNQ------HGFSEDFEEVQRC----TADMNITAEHSNHPENKHK-NRYINILAYDHSRVKLRPLPGKDS-------------------KHSDYINANYVDGYNKAhPTPgamma_D1 (NP_002832) PTPRG (1) KQFGKHIGELYSNSQ------HGFSEDFEEVQRC----TADMNITAEHSNHPDNKHK-NRYINILAYDHSRVKLRPLPGKDS-------------------KHSDYINANYVDGYNKAmPTPgamma_D1 (NP_033007) Ptprg (1) IPIPDDMEAIPVKQF--GKSQHGFSGDFEEVQRC----TADMNITAEHSNHPDNKHK-NRYINILAYDHSRVKLRPLPGKDS-------------------KHSDYINANYVDGYNKArPTPgamma _D1 (NP_599183) Ptprg (1) KQFVKHISELYSNNQ------HGFSEDFEEVQRC----TADMNITAEHSNHPDNKHK-NRYINILAYDHSRVKLRPLPGKDS-------------------KHSDYINANYVSGYNKAcPTPgamma_D1 (Q98936) (1) KHFPKHVADLHASSG-FTEEFETLKEFYQEVQSC----TVDLGITADSSNHPDNKHK-NRYINIVAYDHSRVKLAQLAEKDG-------------------KLTDYINANYVDGYNRPhPTPzeta_D1 (NP_002842) PTPRZ1 (1) KHFPKHVADLHASNG-FTEEFETLKEFYQEVQSC----TVDLGITADSSNHPDNKHK-NRYVNIVAYDHSRVKLTQLAEKDG-------------------KLTDYINANYVDGYNRPrPTPzeta_D1 (NP_037212) Ptprz1 (1) KHFPKHVADLHASNG--------FSEEFEEIQSC----TVDLGITSDSSNHPDNKNK-NRYINIVAYDHTRVKLAQLAEKDG-------------------KLTDYINANYVDGYNKPcPTPzeta_D1 (AAA49015) (1) KQFHKHVEDLHSRNG--------FTDEFEEVQNC----TTDLGITYENSNHPDNKNK-NRYINIVAYDHSRVKLSQLAEKDG-------------------KATDYINANFVDGYNKQxPTPzeta_D1 (BAA97445) (1) DILLETYKRKIADEG------RLFLAEFQSIP------RVFSKFPIKEARKPFNQNK-NRYVDILPYDYNRVELSEINGD---------------------AGSNYINASYIDGFKEPhCD45_D1 (NP_002829) PTPRC (1) DILLETYKRKIADEG------RLFLAEFQSIP------RVFSKFPIKDARKPHNQNK-NRYVDILPYDYNRVELSEINGD---------------------AGSTYINASYIDGFKEPmCD45_D1 (NP_035340) Ptprc (1) DLLLETYKRKIADEG------RLFLAEFQSIP------RVFSKFPIKDARKSQNQNK-NRYVDILPYDYNRVELSEINGD---------------------AGSTYINASYIDGFKEPrCD45_D1 (XP_213985) Ptprc (1) EKLLETYKRKIADEG------RLFLDEFQSIP------RIFTKFPMKEAKRSHNQNK-NRYIDILPYDHNRVELSEIPGD---------------------PGSDYINASYIDGFKEPcCD45_D1 (A54080) (1) GGLVEAYKNKIADEG------RLFMDEFQSIP------RIFSNYTIKEAKKSENQYK-NRYVDILPYDYNRVTLSTGGED------------------------NYINASFIEGYREPcypcaCD45_D1 (BAA92179) (1) ETLLDAYKRKIADEG------RLFLAEFQSIP------RIFSKYTVKEAKKSHNVPK-NRYVDILPYDYNRVQLTTGNGS---------------------AGCDYINASFIDGFKELfuCD45_D1 (CAB96211) (1) EQLIDVYRRKQADES------RLFLAEFQSIP------RVFSKFSVKEARRGCNTNK-NRYVDILPYDHNRVQLSPIAGE---------------------QGSDYINASFIDGFNESsharkCD45_D1 (T43148) (1) ENFEAYFKKQQADSN------CGFAEEYEDLK------LVGISQPKYAAELAENRGK-NRYNNVLPYDISRVKLSVQTHS----------------------TDDYINANYMPGYHSKhDEP1_D1 (NP_002834) PTPRJ (1) ENFEAYFKKQQADSN------CGFAEEYEDLK------LIGISLPKYAAEIAENRGK-NRYNNVLPYDISRVKLSVQTHS----------------------TDDYINANYMPGYHSKrDEP1_D1 (NP_058965) Ptprj (1) ENFEAYFKKQQADSN------CGFAEEYEDLK------LIGISLPKYTAEIAENRGK-NRYNNVLPYDISRVKLSVQTHS----------------------TDDYINANYMPGYHSKmDEP1_D1 (NP_033008) Ptprj (1) DDFDAYIKDMAKDSD------YKFSLQFEELK------LIGLDIPHFAADLPLNRCK-NRYTNILPYDFSRVRLVSMNEE---------------------EGADYINANYIPGYNSPhGLEPP1_D1 (NP_109592) PTPRO (1) DDFDSYIKDMAKDSD------YKFSLQFEELK------LIGLDIPHFAADLPLNRCK-NRYTNILPYDFSRVRLVSMNEE---------------------EGADYINANYIPGYNSPrGLEPP1_D1 (NP_059032) Ptpro (1) DDFDSYIKDMAKDSD------YKFSLQFEELK------LIGLDIPHFAADLPLNRCK-NRYTNILPYDFSRVRLVSMNEE---------------------EGADYINANYIPGYNSPmPTPphi_D1 (NP_035346) Ptpro (1) DDFDAYIKDMAKDSD------YKFSLQFEELK------LIGLDIPHFAADLPLNRCK-NRYTNILPYDFSRVRLLSMNEE---------------------EGADYINANYIPGYNSPrabPTPoc_D1 (AAB16824) (1) NQFEGHFMKLQADSN------YLLSKEYEELK------DVGRNQSCDIALLPENRGK-NRYNNILPYDATRVKLSNVDDD---------------------PCSDYINASYIPGNNFRhPTPbeta_D1 (NP_002828) PTPRB (1) NQFEGHFMKLQADSN------YLLSKEYEDLK------DVGRSQSCDIALLPENRGK-NRYNNILPYDASRVKLSNVDDD---------------------PCSDYINASYIPGNNFRmPTPbeta_D1 (NP_084204) Ptprb (1) NQFEGHFMKLQADSN------YLLSKEYEDLK------DVGRSQSCDIALLPENRGK-NRYNNILPYDASRVKLCNVDDD---------------------PCSDYINASYIPGNNFRrPTPbeta_D1 (XP_235156 (revised)) (1) KSFLQHVEELCTNNN------LKFQEEFSELP------KFLQDLSSTDADLPWNRAK-NRFPNIKPYNNNRVKLIADASV---------------------PGSDYINASYISGYLCPhPTPS31_D1 (AR073855) PTPGMC1 (1) KSFLQHVEELCTNSN------LKFQEEFSELP------KFLQDLSSTDADLPWNRAK-NRFPNIKPYNNNRVKLIADVSL---------------------PGSDYINASYVSGYLCPrPTPGMC1_D1 (NP_075214) Ptprq (1) EDFADHVRKNERDSN------CGFADEYQQLS------LVGHSQSQMVASASENNAK-NRYRNVLPYDWSRVPLKPIHEE---------------------PGSDYINASFMPGLWSPhSAP1_D1 (NP_002833) PTPRH (1) KDFADHVRENEKDSN------CGFAEEYQQLA------LEGQGQSQITASALENRSK-NRYRNVLPYDWSRVPLQPLQEE---------------------PGSDYINASFMPGLWSPmSAP1_D1 (BAC37443) (1) KDFADHVRENEKDSN------CGFAEEYQQLA------LEGQGQSQMTALALENVSK-NRYRNVLPYDWSRVPLQPLHEE---------------------PGSDYINASFMPGLWSPrPTPBEM2_D1 (NP_598276) (1) HSFRQSYEAKSARAH------QAFFQEFEELK------EVGKDQPRLEAEHPANITK-NRYPHVLPYDHSRVRLTQLSGE---------------------PHSDYINANFIPGYSHPmPTPESP_D1 (NP_031981) Esp (1)

http://ptp.cshl.edu or http://science.novonordisk.com/ptp

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VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

HSFRQSYEAKSAHAH------QTFFQEFEELK------EVGKDQPRLEAEHPDNIIK-NRYPHVLPYDHSRVRLTQLPGE---------------------PHSDYINANFIPGYSHTrOSTPTP_D1 (NP_149090) Esp (1) SRILTRSQLRDVVASS-----HLLQSEFMEIP--------MNFVDPKEIDIPRHGTK-NRYKTILPNPLSRVCLRPKNVTD--------------------SLSTYINANYIRGYSGKhPCPTP1_D1 (NP_002840) PTPRR (1) SRVLTSPQLRDVVASS-----HLLQSEFMEIP--------MNFVDPKEIDIPRHGTK-NRYKTILPNPLSRVCLRPKNITD--------------------PLSTYINANYIRGYSGKrPCPTP1_D1 (NP_446046) Ptprr (1) SRVLTRSQLRDVVASS-----HLLQSEFMEIP--------MNFVDPKEIDIPRHGTK-NRYKTILPNPLSRVCLRPKNITD--------------------SLSTYINANYIRGYSGKmPTPSL_D1 (NP_035347) Ptprr (1) SRVLQAEELHEKALDP-----FLLQAEFFEIP--------MNFVDPKEYDIPGLVRK-NRYKTILPNPHSRVCLTSPDPDD--------------------PLSSYINANYIRGYGGEhSTEP_D1 (NP_116170) PTPN5 (1) SRVLRAEELHEKALDP-----FLLQAEFFEIP--------MNFVDPKEYDIPGLVRK-NRYKTILPNPHSRVRLTSPDPED--------------------PLSSYINANYIRGYSGEmSTEP_D1 (NP_038671) Ptpn5 (1) SRVLRAEELHEKALDP-----FLLQAEFFEIP--------MNFVDPKEYDIPGLVRK-NRYKTILPNPHSRVRLTSPDPED--------------------PLSSYINANYIRGYNGErSTEP_D1 (NP_062126) Ptpn5 (1) HPLTRWALQRQPPSP------KQLEEEFLKIP--------SNFVSPEDLDIPGHASK-DRYKTILPNPQSRVCLGRAQSQ---------------------EDGDYINANYIRGYDGKhHePTP_D1 (NP_002823) PTPN7 (1) HPLTRWTLQHQPPSP------KQLEEEFLKIP--------SNFVNPEDLDIPGHASK-DRYKTILPNPQSRVCLGRAQSQ---------------------EDSDYINANYIRGYDGKmHePTP_D1 (NP_796055) Ptpn7 (1) HPLTRWTLQHQPPSP------KQLEEEFLKIP--------SNFVNPEDLDIPGHASK-DRYKTILPNPQSRVCLGRAHSQ---------------------EDSDYINANYIRGYDGKrLCPTP_D1 (P49445) Ptpn7 (1) EILQKFLDEAQSKKI----TKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKK-NRYKDILPYDYSRVELSLITSD---------------------EDSSYINANFIKGVYGPhLyPTP_D1 (NP_057051) PTPN22 (1) EILQQLLKEAQKKKL----NSEEFASEFLKLKRQSTKYKADKIYPTTVAQRPKNIKK-NRYKDILPYDHSLVELSLLTSD---------------------EDSSYINASFIKGVYGPmPEP_D1 (NP_033005) Ptpn8 (1) EILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKK-NRYKDILPFDHSRVKLTLKTPS---------------------QDSDYINANFIKGVYGPhPEST_D1 (NP_002826) PTPN12 (1) EILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKK-NRYKDILPFDHSRVKLTLKTPS---------------------QDSDYINANFIKGVYGPrRKPTP_D1 (NP_476456) Ptpn12 (1) EILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKK-NRYKDILPFDHSRVKLTLKTPS---------------------QDSDYINANFIKGVYGPmPEST_D1 (NP_035333) Ptpn12 (1) DSARSFLERLEARGG---REGAVLAGEFSDIQACSAAWKADGVCSTVAGSRPENVRK-NRYKDVLPYDQTRVILSLLQEE---------------------GHSDYINGNFIRGVDGShBDP1_D1 (NP_055184) PTPN18 (1) DLVRSLLEQLEARDY---REGAILAREFSDIKARSVAWKSEGVCSTKAGSRLGNTNK-NRYKDVVAYDETRVILSLLQEE---------------------GHGDYINANFIRGIDGSmPTPK1_D1 (NP_035336) Ptpn18 (1) DLVRSFLEQQEARDH---RKGAILAREFSDIKARSVAWKTEGVCSTKAGSQQGNSKK-NRYKDVVPYDETRVILSLLQEE---------------------GHGDYINANFIRGTDGSrPTP20_D1 (AAC52896) (1) ADIENRVLELNKKQESEDTAKAGFWEEFESLQKQ----EVKNLHQRLEGQRPENKGK-NRYKNILPFDHSRVILQGRDSNI--------------------PGSDYINANYIKNQLLGhSHP1_D1 (NP_002822) PTPN6 (1) ADIENRVLELNKKQESEDTRKAGFWEEFESLQKQ----EVKNLHQRLEGQRPENKSK-NRYKNILPFDHSRVILQGRDSNI--------------------PGSDYINANYVKNQLLGmSHP1_D1 (NP_038573) Hcph (1) ADIENRVLELNKKQESEDTAKAGFWEEFESLQKQ----EAKNLHQRLEGQRPENKSK-NRYKNILPFDHSRVILQGRDSNI--------------------PGSDYINANYVKNQLLGrSHP1_D1 (NP_446360) Ptph6 (1) VNQLDQTSEREKMDGADKKIKAGFWEEFDALQKL----ETKVTKSRDEGMRPENKSK-NRYKNILPFDETRVILENADPNV--------------------VGSDYINANYVINKLMVzSHP1_D1 (AAH44414) (1) -----------------------------LLQQQ----EYKLLYSRKEGQRIENKSK-NRYKNILPFDNTRVRLKEVDESV--------------------VGSDYINANNITNGKNGryPTPN6c_D1 (BAA95199) (1) AEIESRVRELSKLAETTDKVKQGFWEEFETLQQQ----ECKLLYSRKEGQRQENKNK-NRYKNILPFDHTRVVLHDGDPNE--------------------PVSDYINANIIMPEFEThSHP2_D1 (NP_002825) PTPN11 (1) AEIESRVRELSKLAETTDKVKQGFWEEFETLQQQ----ECKLLYSRKEGQRQENKNK-NRYKNILPFDHTRVVLHDGDPNE--------------------PVSDYINANIIMPEFETmSHP2_D1 (NP_035332) Ptpn11 (1) AEIESRVRELSKLAETTDKVKQGFWEEFETLQQQ----ECKLLYSRKEGQRQENKNK-NRYKNILPFDHTRVVLHDGDPNE--------------------PVSDYINANIIMPEFETrSHP2_D1 (NP_037220) Ptpn11 (1) AEIESRVRELSKLAETTDKVKQGFWEEFETLQQQ----ECKLLYSRKEGQRQENKNK-NRYKNILPFDHTRVVLHDGDPNE--------------------PVSDYINANIIMPEFETcSHP2_D1 (JC5167) (1) AEIESRVRELSKLAEATDKVKQGFWEEFETLQQQ----ECKLLYSRKEGQRPENKNK-NRYKNILPFDHTRVVLTDGDVNE--------------------QGSDYINANLIMPDNEAzSHP2_D1 (AAH45328) (1) AEIEIRVKELSKPAETADKFKQGFWEEFETLQQQ----ECKLLYSRKEGQRPENKNK-NRYKNILPFDHTRVELHDGDPNE--------------------QVSDYINANIIMPEFEIxSHP2_D1 (A55651) (1) -----------------------------TLQQQ----ECKLLYSRKDGQRQENKYK-NRYKNILPFDHTRVVLHDGDVTE--------------------PGSDYINANFILHDIDSryPTPN6b_D1 (BAA95198) (1) ATNDERCKILEQRLE-----QGMVFTEYERILK-----KRLVDGECSTARLPENAER-NRFQDVLPYDDARVELVPTKEN----------------------NTGYINASHIKVSVSGhPTPD1_D1 (NP_008970) PTPN21 (1) ATNDERCKVLEQRLE-----QGMVFTEYERILK-----KRLVDGECSTARLPENAER-NRFQDVLPYDDARVELVPTKEN----------------------NTGYINASHIKVSVSGmPTPRL10_D1 (NP_036007) Ptpn21 (1) ATNDERCKVLEQRLE-----QGTVFTEYERILK-----KRLVDGECSTARLPENAER-NRFQDVLPYDDARVELVPTKEN----------------------NTGYINASHIKVSVSGrPTP2E_D1 (NP_598229) Ptp2E (1) VPMDERFRTLKKKLE-----EGMVFTEYEQIP------KKKANGIFSTAALPENAER-SRIREVVPYEENRVELIPTKEN----------------------NTGYINASHIKVVVGGhPTPD2_D1 (NP_005392) PTPN14 (1) VPIDERLRALKKKLE-----DGMVFTEYEQIP------NKKANGVFSTATLPENAER-SRIREVVPYEENRVELIPTKEN----------------------NTGYINASHIKVVVGGmPTP36_D1 (NP_033002) Ptpn14 (1) VPMDERLRALKKKLE-----DGMVFTEYEQIP------NKKANGIFSTATLPENAER-SRIREVVPYEENRVELIPTKEN----------------------NTGYINASHIKVVVGGrPTPD2_D1 (XP_223062 (revised)) (1) HSLRESMIQLAEGLI-----TGTVLTQFDQLY------RKKPGMTMSCAKLPQNISK-NRYRDISPYDATRVILKG--------------------------NEDYINANYINMEIPShMEG1_D1 (NP_002821) PTPN4 (1) HSLRESMIQLAEGLI-----TGTVLAQFDQLY------RKKPGMTMSCAKLPQNISK-NRYRDISPYDATRVLLKG--------------------------NEDYINANYINMEIPSmMEG1_D1 (NP_064317) Ptpn4 (1) DAWRDSMLYLKEGLN-----SGTILAQFDQLY------RKRPGMTMSCAKLPQNISK-NRYRDISPYDATRVILKG--------------------------TEDYINANYINMEIPAzMEG1_D1 (CAD43435) (1) DTLEGSMAQLKKGLE-----SGTVLIQFEQLY------RKKPGLAITFAKLPQNLDK-NRYKDVLPYDTTRVLLQG--------------------------NEDYINASYVNMEIPAhPTPH1_D1 (NP_002820) PTPN3 (1) DSLEGSMELLKKGLE-----SGTVLIQFEQLY------RKKPGLAVSFAKLPQNLDK-NRYKDVLPYDTTRVLLQG--------------------------NEDYINASYVNMEMPAmPTPH1_D1 (XP_143789) Ptpn3 (1) ANLKSVIRVLRGLLD-----QGIPSKELENLQ------ELKPLDQCLIGQTKENRRK-NRYKNILPYDATRVPLGD--------------------------EGGYINASFIKIPVGKhPTPBAS_D1 (NP_006255) PTPN13 (1) TQLQATIRTLQGLLD-----QGIPSKELENLQ------ELKPLDQCLIGQTKENRRK-NRYKNILPYDTTRVPLGD--------------------------EGGYINASFIRIPVGTmPTPBL_D1 (NP_035334) Ptpn13 (1) AKLKSVIRMLRGLLD-----QGIPSKELENLQ------ELKPLDQCLIGQTKENRRK-NRYKNILPYDATRVPLGD--------------------------EGGYINASFIKIPVGRbPTPBA14_D1 (NP_777015) PTPN13 (1) TAIKDCLKILEEKTA-----AYDIMQEFMALE------LKNLPGEFYSGNQPSNREK-NRYRDILPYDSTRVPLGK--------------------------SKDYINASYIRIVNCGhPTPTyp_D1 (AL050040) PTPN20 (1) SAMRDCLNTLQKKEE------LDIIREFLELE------QMTLPDDFNSGNTLQNRDK-NRYRDILPYDSTRVPLGK--------------------------NKDYINASYIRIVNHEmPTPTyp_D1 (NP_033004) Ptpn20 (1) MEIEKEFHRLDQAAS--------WAAIYQDIR------HEASDFPCKVAKHPRNKNR-NRYRDVSPFDHSRIKLNQG-------------------------DNDYINASLIKMEEAQcPTP1B_D1 (O13016) (1) MEMEKEFEQIDKSGS--------WAAIYQDIR------HEASDFPCRVAKLPKNKNR-NRYRDVSPFDHSRIKLHQEDN-------------------------DYINASLIKMEEAQhPTP1B_D1 (NP_002818) PTPN1 (1) MEMEKEFEEIDKAGN--------WAAIYQDIR------HEASDFPCKVAKLPKNKNR-NRYRDVSPFDHSRIKLHQEDN-------------------------DYINASLIKMEEAQmPTP1B_D1 (NP_035331) Ptpn1 (1) MEMEKEFEQIDKAGN--------WAAIYQDIR------HEASDFPCRIAKLPKNKNR-NRYRDVSPFDHSRIKLHQEDN-------------------------DYINASLIKMEEAQrPTP1B_D1 (NP_036769) Ptpn1 (1) --MEAEFREIDEHGN--------WNDVYQEIR------QQSSDLPCKIAKLPENRSR-NRYRDVSPFDHSRICLQIGCN-------------------------DYINASLISVEEAQzPTP1B_D1 (NP_570999) ptp1b (1) TTIEREFEELDTQRR--------WQPLYLEIR------NESHDYPHRVAKFPENRNR-NRYRDVSPYDHSRVKLQNAEN-------------------------DYINASLVDIEEAQhTCPTP_D1 (NP_002819) PTPN2 (1) ATIEREFEELDAQCR--------WQPLYLEIR------NESHDYPHRVAKFPENRNR-NRYRDVSPYDHSRVKLQSTEN-------------------------DYINASLVDIEEAQmTCPTP_D1 (NP_033003) Ptpn2 (1) ATIEREFEELDAQCR--------WQPLYLEIR------NESHDYPHRVAKFPENRNR-NRYRDVSPYDHSRVKLQSAEN-------------------------DYINASLVDIEEAQrTCPTP_D1 (NP_446442) Ptpn2 (1) --MEQEFEDIDSEGR--------WQNIYLEIR------NQSHECAFKVAKYPENRIR-NRYRDVSPFDHSRVKLENTEN-------------------------DYINASLVVMEEAQzTCPTP_D1 (AAH44373) (1) MTIQELVDYVNARQK------QGIYEEYEDIR------RENPVGTFHCSMSPGNLEK-NRYGDVPCLDQTRVKLTKRSGH---------------------TQTDYINASFMDGYKQKhMEG2_D1 (NP_002824) PTPN9 (1) MTIQELVDYVNTRQK------RGIYEEYEDIC------LENPVGTFHRTMSPRNLEK-NRYGDVPCLDQTRVKLTKRSGH---------------------TQTDYINASFMDGYKQKmMEG2_D1 (NP_062625) Ptpn9 (1) MMVLDLVQHVKRMKK------RGIFQEYEEIR------KDPPVGSFDISKKSHNQVK-NRYSDVLCLDQSRVKLGLVGTD---------------------ETTDYINASFMDGYKRKxPTPX10_D1 (B53978) (1) MMVLGLVQHVKRMKK------RGIFQEYEEIR------KDPPVGSFDISKKSHNQAK-NRYSDVLCLDQSRVKLGLVGTD---------------------ETTDYINASFMDGYKRKxPTPX1_D1 (AAH43621) (1) ERLRQLQQELEAFRG-----QLGDVGALDTVWRELQDAQEHDARGRSIAIARCYSLK-NRHQDVMPYDSNRVVLRSGK-------------------------DDYINASCVEGLSPYhHDPTP_D1 (NP_056281) PTPN23 (1) ERLQQLQQELEAFRG-----QLGDAGALDAIWRELQEAQEHDARGRSIAIARCYSLK-NRHQDVMPYDSNRVVLRSGK-------------------------DDYINASCVEGLSPYmHDPTP_D1 (AAH22721) (1) ERLQKLQQELESFRG-----QLGDAGALDAVWRELQEAQEHDARGRSIAIARCYSLK-NRHQDVMPYDSNRVVLRSGK-------------------------DDYINASCVEGLSPYrPTPTD14_D1 (T14355) (1) HMILAYMEDHLRNRD-------RLAKEWQALCAY-----QAEPNTCATAQGEGNIKK-NRHPDFLPYDHARIKLKVESSP---------------------SRSDYINASPIIEHDPRhIA2_D1 (NP_002837) PTPRN (1) HMILAYMEDHLRNRD-------RLAKEWQALCAY-----QAEPNTCAAAQDESNIKK-NRHPDFLPYDHARIKLKVESSP---------------------SRSDYINASPIIEHDPRmIA2_D1 (NP_033011) Ptprn (1) HMILAYMEDHLRNRD-------RLAKKWQALCAY-----QAEPNTCATAQGEGNIKK-NRHPDFLPYDHARIKLKVESSP---------------------SRSDYINASPIIEHDPRrIA2_D1 (NP_446333) Ptprn (1)

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Page 3: Alignment 195 Vert PTP Domainsptp.cshl.edu/downloads/ptp_alignment_files/...VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

HMILAYMEDHLRNRD-------RLAKEWQALCAY-----QAEPNTCATAQGEGNIKK-NRHPDFLPYDHARIKLKVESSP---------------------SRSDYINASPIIEHDPRbIA2_D1 (P56722) Ptprn (1) HMILSYMEDHLKNKN-------RLEKEWEALCAY-----QAEPNSSFVAQREENVPK-NRSLAVLTYDHSRVLLKAENSH---------------------SHSDYINASPIMDHDPRhIA2beta_D1 (NP_002838) PTPRN2 (1) HMILSYMEDHLKNKN-------RLEKEWEALCAY-----QAEPNSSLVAQKEENVPK-NRSLAVLTYDHSRVLLKAENSH---------------------SHSDYINASPIMDHDPRmacneIA2beta_D1 (O02695) (1) HMILAYMEDHLKNKN-------RLEKEWEALCAY-----QAEPNSSLVAQREENAPK-NRSLAVLTYDHSRILLKSQNSH---------------------GSSDYINASPIMDHDPRmPTPNP_D1 (P80560) Ptprn2 (1) HMILAYMEDHLKNKN-------RLEKEWEALCAY-----QAEPDSSLVAQREENAPK-NRSLAVLTYDHSRILLKSENSH---------------------SNSDYINASPIMDHDPRrPTPNE6_D1 (NP_113788) Ptprn2 (1) SELHPYLHNMKKRDPP--SEPSPLEAEFQRLP------SYRSWRTQHIGNQEENKSK-NRNSNVIPYDYNRVPLKHELEMS--KESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPhCD45_D2 (NP_002829) PTPRC (1) SELHSCLHNMKKRDPP--SDPSPREAEYQRLP------SYRSWRTQHIGNQGENKKK-KRNSNVVPYDFNRVPLKHELEMS--KESEPESDESSDDDSDSEETSKYINASFVMSYWKPmCD45_D2 (NP_035340) Ptprc (1) SELHSCLQNLKKRDPP--SDPSPLEAEYQRLP------SYRSWRTQHIGNQEENKKK-NRSSNVVPYDFNRVPLKHELEMS--KESEAESDESSDEDSDSEETSKYINASFVMSYWKPrCD45_D2 (XP_213985) Ptprc (1) SELHSYLNNLKRKDPP--SEPSLLEAKFQRLP------SYKGWRTQNTGNREENKNK-NRSANTIPYDFNRVPIRSEEEQS--KEGEHDSEDSSDEDSDCEESSRYINASFITGYWGPcCD45_D2 (A54080) (1) QELHSTLNTLKQRSSD--NEPTLLEDEFERLP------NFKNWRTFNTGVTEENKKK-NRTSSVIPYDYNRVLLKLDEEKSHESDPDPDDDYDTSSYDDIEDSAKYINASLLSGYWGPfuCD45_D2 (CAB96211) (1) SEFHSVLNTLRQKNG---SDPSLLEKEFQKLP------KFKKWRTMNTGSSEDNKKK-NRDSAVIPYDFNRVIFRLDIEGN---QTSDPEDEEEYSSDEEEESNQYINASFIDGYWCNcypcaCD45_D2 (BAA92179) (1) --------NMKKRDPP--SEPSPLEAEFQRLP------SYRSWRTQHIGNQEENKSK-NRNSNVIPYDFNRVPLKHELEMS--KESEHDSDESSDDDSDSEEXSKYINASFIMXXWKPaotvoCD45_D2 (AAM48512) (3') (1) SELPKHLINFKKNDPP--SEPSMLEGEFQRIP------PYTDWRTQTTGRRGENQSK-NRSLSVIAYDYNRVTIKLEDEKS-KDSTSHSDSDLSSDDSEDEESTKYINASYIDGYWHSsharkCD45_D2 (T43148) (1) TSLEIHLQKIYNKVP--GTSSNGLEEEFKKLTS-----IKIQNDKMRTGNLPANMKK-NRVLQIIPYEFNRVIIPVKRGE---------------------ENTDYVNASFIDGYRRRcPTPalpha_D2 (AAB04150) (1) TSLETHLQKIYNKIP--GTSNNGLEEEFKKLTS-----IKIQNDKMRTGNLPANMKK-NRVLQIIPYEFNRVIIPVKRGE---------------------ENTDYVNASFIDGYRQKhPTPalpha_D2 (NP_002827) PTPRA (1) TSLETHLQKIYNKIP--GTSNNGLEEEFKKLTS-----IKIQNDKMRTGNLPANMKK-NRVLQIIPYEFNRVIIPVKRGE---------------------ENTDYVNASFIDGYRQKmPTPalpha_D2 (NP_033006) Ptpra (1) TSLDTHLQKIYNKIP--GTSNNGLEEEFKKLTS-----IKIQNDKMRTGYLPANMKK-NRVLQIIPYEFNRVIIPVKRGE---------------------ENTDYVNASFIDPYRQKrPTPalpha_D2 (NP_036895) Ptpra (1) TSLETHLQKLYSKFP--GTNSTGLEEEFKKLTS-----IKIQNDKMRTGNFPAYMKE-NRVLQIIPYEFNRVIIPVKRGE---------------------ENTDYVNASFIDGYRQKxPTPalpha_D2 (AAA17990) (1) TSLETHMNKLYAPLP--GAGCGGLEAEFKKLTS-----IKIQNDKMRTGNLPANMKK-NRVLQIIPYEFNRVIIPVKRGE---------------------ENTDYINASFIDGYRQKzPTPalpha_D2 (NP_571963) ptpra (1) TSLESHLQKLYNRVS--GSGCNGLEEEFKKLTS-----IKIQNDKMRTGNLPANMKK-NRVLQIIPYEFNRVIIPVKRGE---------------------ENTDYVNASFIDGYRQKryPTPR4b_D2 (BAA95196) (1) SSLEKHLQTMHGTTT--HFDKIGLEEEFRKLTN-----VRIMKENMRTGNLPANMKK-ARVIQIIPYDFNRVILSMKRGQ---------------------EYTDYINASFIDGYRQKhPTPepsilon_D2 (NP_006495) PTPRE (1) SSLERHLQTLHSTAT--HFDKIGLEEEFRKLTN-----VRIMKENMRTGNLPANMKK-ARVIQIIPYDFNRVILSMKRGQ---------------------EFTDYINASFIDGYRQKmPTPepsilon_D2 (NP_035342) Ptpre (1) SSLERHLQTLHGTAT--HFDKIGLEEEFRKLTN-----VRIMKENMRTGNLPANMKK-ARVIQIIPYDFNRVILSMKRGQ---------------------EFTDYINASFIDGYRQKrPTPepsilon_D2 (XP_215102) Ptpre (1) CSLEGHLHRLHNTRA--PNDRLGLEEEFRKLTN-----VRIMKENMRTGNLPANMRK-NRVLQIIPYDFNRVILSVRRGQ---------------------EFTDYINASFIDGYRQKorylaPTPepsilon_D2 (BAC06424) (1) SSLEKHIQKLRNKTG--KFDITGLEEEFNKLTT-----VRIRKDNMRTGNKPVNMKK-ARVLQIIPYDFNRVVLPRKRGQ---------------------EFSDYINASYIDGYRQKryPTPR4a_D2 (BAA95190) (1) KAAYFDMIRIDSQTN-----SSHLKDEFQTLNS---VTPRLQAEDCSIACLPRNHDK-NRFMDMLPPDRCLPFLITIDG----------------------ESSNYINAALMDSYRQPhPTPkappa_D2 (NP_002835) PTPRK (1) KAAYFDMIRIDSQTN-----SSHLKDEFQTLNS---VTPRLQAEDCSIACLPRNHDK-NRFMDMLPPDRCLPFLITIDG----------------------ESSNYINAALMDSYRQPmPTPkappa_D2 (NP_033009) Ptprk (1) KQAYYEMIRVDSQSN-----SSQLKDEFQTLNS---VSSQLQPEDCSIALLPRNHEK-NRYMDALPPDRCLPFLITIDG----------------------ESSNYINAALMDSYRQPryPTPR2B_D2 (BAA95194) (1) KATYKEMIRIDPQSN-----SSQLREEFQTLNS---VTPPLDVEECSIALLPRNRDK-NRSMDVLPPDRCLPFLISTDG----------------------DSNNYINAALTDSYTRShPTPlamda_D2 (NP_005695) PTPRU (1) RATYREMIRIDPQSN-----SSQLREEFQTLNS---VTPPLDVEECSIALLPRNRDK-NRSMDVLPPDRCLPFLISSDG----------------------DPNNYINAALTDSYTRSmPTPlamda_D2 (NP_035344) Ptprl (1) RSLYYDMNKLDPQTN-----SSQIKEEFRTLNM---VTPTLRVEDCSIALLPRNHEK-NRCMDILPPDRCLPFLITIDG----------------------ESSNYINAALMDSYKQPhPTPmu_D2 (NP_002836) PTPRM (1) RSLYYDMNKLDPQTN-----SSQIKEEFRTLNM---VTPTLRVEDCSIALLPRNHEK-NRCMDILPPDRCLPFLITIDG----------------------ESSNYINAALMDSYKQPmPTPmu_D2 (NP_033010) Ptprm (1) RSLYYDMNKLDPQTN-----SSQIKEEFRTLNM---VTPTLRVEDCSIALLPRNHEK-NRCMDILPPDRCLPFLITIDG----------------------ESSNYINAALMDSYKQPrPTPmu_D2 (XP_237546 (revised)) (1) RSLYYNISRLDPQTN-----SSQIKDEFQTLNI---VTPRVRPEDCSIGLLPRNHDK-NRSMDVLPLDRCLPFLISVDG----------------------ESSNYINAALMDSHKQPhPTPrho_D2 (NP_573400) PTPRT (1) RSLYYNISRLDPQTN-----SSQIKDEFQTLNI---VTPRVRPEDCSIGLLPRNHDK-NRSMDVLPLDRCLPFLISVDG----------------------ESSNYINAALMDSHKQPmPTPrho_D2 (NP_067439) Ptprt (1) RNLYTYIQKLAQIEVG--EHVTGMELEFKRLAN-----SKAHTSRFISANLPCNKFK-NRLVNIMPYETTRVCLQPIRG---------------------VEGSDYINASFIDGYRQQcPTPsigma_D2 (I50212) (1) RNLYAHIQKLGQVPPG--ESVTAMELEFKLLAS-----SKAHTSRFISANLPCNKFK-NRLVNIMPYELTRVCLQPIRG---------------------VEGSDYINASFLDGYRQQhLAR_D2 (NP_002831) PTPRF (1) RNLYAHIQKLGQVPPG--ESVTAMELEFKLLAN-----SKAHTSRFVSANLPCNKFK-NRLVNIMPYELTRVCLQPIRG---------------------VEGSDYINASFLDGYRQQmLAR_D2 (NP_035343) Ptprf (1) RNLYAHIQKLGQVPPG--ESVTAMELEFKLLAG-----SKARASRFISANLPCNKFK-NRLVNIMPYELTRVCLQPIRG---------------------VEGSDYINASFLDGYRQQrLAR_D2 (NP_062122) Ptprf (1) RSLYAHIQKLSQVPPG--ESVTSMELEFKLLAN-----SKAHTSRFISANLPCNKFK-NRLVNIMPYELSRVSLQPIRG---------------------VEGSDYINASFIDGYRQQxLAR_D2 (AAF43606) (1) RSLYTHIQKLTQAPPG--DTVTAMELEFKKLAN-----SKAHTSRFISASLPCNKFK-NRLVNIMPFESSRVCLQPIRG---------------------VEGSDYINASFIDGYRQQzLAR_D2 (CAC44758) (1) RSLFAHIQKLGQVPPA--ETVTAMELEFKRLAN-----SKAHTSRFISANLPCNKFK-NRLVNIMPYESTRVCLQPIRG---------------------VEGSDYINASFIDGYRQQryPTPR2Aa_D2 (BAA95188) (1) RNLYAYIQKLTQIETG--ENVTGMELEFKRLAS-----SKAHTSRFISANLPCNKFK-NRLVNIMPYESTRVCLQPIRG---------------------VEGSDYINASFIDGYRQQhPTPdelta_D2 (NP_002830) PTPRD (1) RNLYAYIQKLTQIETG--ENVTGMELEFKRLAS-----SKAHTSRFISANLPCNKFK-NRLVNIMPYESGRVCLQPIRG---------------------VEGSDYINASFLDGYRQQmPTPdelta_D2 (D54689) (1) RNLYAYIQKLTQIEPG--ENVTGMELEFKRLAS-----FKAHTSRFISANLPCNKFK-NRLVNIMPYESTRVCLQPIRG---------------------VEGSDYINASFIDGYRQQxPTPdelta_D2 (AAF43605) (1) RNLYAYIQKLTQVEPG--ENVTGMELEFKRLAN-----TKAHTSRFISANLPCNKFK-NRLVNIMPYESTRVCLQPIRG---------------------VEGSDYINASFIDGYRQQryPTPR2Ab_D2 (BAA95191) (1) RSLYAYIQKLAQVEPG--EHVTGMELEFKRLAN-----SKAHTSRFISANLPCNKFK-NRLVNIMPYESTRVCLQPIRG---------------------VEGSDYINASFIDGYRQQhPTPsigma_D2 (NP_002841) PTPRS (1) RSLYTYIQKLAQVEPG--EHVTGMELEFKRLAS-----SKAHTSRFITASLPCNKFK-NRLVNILPYESSRVCLQPIRG---------------------VEGSDYINASFIDGYRQQmPTPsigma_D2 (NP_035348) Ptprs (1) RNLYTYIQNLAQIDVG--EHVIGMELEFKRLAN-----SKAHTSRFISANLPCNKFK-NRLVNIMPYETTRVCLQPIRG---------------------VEGSDYINASFIDGYRQQxPTPsigma_D2 (AAF43607) (1) RSLFSYIQKLAQVEAG--EHVSGMELEFKRLAN-----SKAHTSRFISANLPCNKFK-NRLVNIMPYETTRVCLQPIRG---------------------LEGSDYINSSFIDGYRQQzPTPsigma_D2 (CAC44759) (1) RSLYTYIQKLAQVEPG--EHVTGMELEFKRLAS-----SKAHTSRFITASLPCNKFK-NRLVNILPYESSRVCLQPIRG---------------------VEGSDYINASFIDGYRQQrPTPsigma_D2 (NP_062013) Ptprd (1) RNLYSYIQKLTQVETG--EHVTGMELEFKRLAN-----SKAHTSRFISANLPCNKFK-NRLVNIMPYETTRVCLQPIRG---------------------VEGSDYINASFIDGYRQQryPTPR2Ac_D2 (BAA95193) (1) NQLHSYVNSILIPGVG---GKTRLEKQFKLVTQ-----CNAKYVECFSAQKECNKEK-NRNSSVVPSERARVGLAPLPG---------------------MKGTDYINASYIMGYYRShPTPgamma_D2 (NP_002832) PTPRG (1) SQLHSYVNSILIPGVG---GKTRLEKQFKLITQ-----CNAKYVECFSAQKECNKEK-NRNSSVVPAERARVGLAPLPG---------------------MKGTDYINASYIMGYYRSmPTPgamma_D2 (NP_033007) Ptprg (1) SQLHSYVNSILIPGVG---GKTRLEKQFKLITQ-----CNAKYVECFSAQKECNKEK-NRNSSVVPAERARVGLAPLPG---------------------MKGTDYINASYIMGYYRSrPTPgamma_D2 (NP_599183) Ptprg (1) SQLHGYVNSILIPGLS---GKMRLEKQFKLVTQ-----CNAKFIECFSAQKECNKEK-NRNSSVVPTERARVGLAPLPG---------------------TKGTDYINASYIMGYYRSryPTPR5b_D2 (BAA95197) (1) NQLHSYVNSILIPGIG---GKTRLEKQFKLVTQ-----CNAKYVECFSAQKDCNKEK-NRNSSVVPSERARVGLAPLPG---------------------MKGTDYINASYIMGYYRScPTPgamma_D2 (Q98936) (1) SHIHAYVNALLIPGPA---GKTKLEKQFQLLSQ-----SNIQQSDYSAALKQCNREK-NRTSSIIPVERSRVGISSLSG----------------------EGTDYINASYIMGYYQShPTPzeta_D2 (NP_002842) PTPRZ1 (1) THIHAYVNALLIPGPT---GKTRLEKQFKLLSQ-----SNTQQCDYSTALKQCNREK-NRTSSIIPVERSRVGISSLSG----------------------EGTDYINASYIMGYYQScPTPzeta_D2 (AAA49015) (1) SHIHSYVNTLLIPGPT---GKTKLEKQFQLLSQ-----SNILQSDYSTALKQCNREK-NRTSSIIPVERSRVGISSLSG----------------------EGTDYINASYIMGYYQSmPTPzeta_D2 (XP_133009) Ptprz1 (1) SHIHSYVNTLLIPGPS---GKTKLEKQFQLLSQ-----SNILQSDYSTALKQCNREK-NRTSSIIPVERSRVGISSLSG----------------------EGTDYINASYIMGYYQSrPTPzeta_D2 (NP_037212) Ptprz1 (1) THIHGYVNTLLTMGPS---GKSRLETQFKLLSE-----PNILQCDYSTALKPQNRDK-NRTSSVIPVERSRVGLSSLAG----------------------EGTDYINASYVMGYHESxPTPzeta_D2 (BAA97445) (1) NHLHTYVNALLTPGPS---GKTKLEKQFKLVSQ-----PHAKQCDYSAALKQCNRDK-NRNSSIIPVERSRVGLATLTA----------------------EGSDYINASYVSGFHRIryPTPR5a_D2 (BAA95195) (1) L I L L EF L A P NK K NRY NILPYD SRV L I SDYINASYI GY Consensus (1)

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VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

Section 2119 236130 140 150 160 170 180 190 200 210 220(119) N--------AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK-SRIKCDQYWPN----RGTETYGFIQVTL-LDTIE-LATFCVRTFSLHKNGSSEKRE-----------VRQFhPTPsigma_D1 (NP_002841) PTPRS (84) N--------AYIATQGPLPETFGDFWRMVWEQRSATVVMMTRLEEK-SRIKCDQYWPN----RGTETYGFIQVTL-LDTME-LATFCVRTFSLHKNGSSEKRE-----------VRHFmPTPsigma_D1 (NP_035348(revised)) Ptprs (84) N--------AYIATQGPLPETFGDFWRMVWEQRSATVVMMTRLEEK-SRVKCDQYWPN----RGTETYGFIQVTL-LDTME-LATFCVRTFSLHKNGSSEKRE-----------VRHFrPTPsigma_D1 (NP_062013) Ptprd (84) N--------AYIATQGPLPETFGDFWRMVWEQRSATIVMMTKLEEK-SRIKCDQYWPG----RGTDTYGMIQVTL-LDTIE-LATFCVRTFSLHKNGSSEKRE-----------VRQFcPTPsigma_D1 (I50212) (84) N--------AYIATQGALPETFGDFWRMVWEQRSATVVMMTKLEEK-SRVKCDQYWPS----RGTETYGMIQVTL-LDTIE-LATFCVRTFSLHKSGSSEKRE-----------VRQFxPTPsigma_D1 (AAF43607) (84) N--------AYIATQGPLPETFGDFWRMVWEQRAATVVMMTRLEEK-SRIKCDQYWPS----RGTETYGMIQVTL-LDTIE-LATFCVRTFSLHKNGSSEKRE-----------VRQFzPTPsigma_D1 (CAC44759) (84) N--------AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEK-SRVKCDQYWPA----RGTETCGLIQVTL-LDTVE-LATYTVRTFALHKSGSSEKRE-----------LRQFhLAR_D1 (NP_002831) PTPRF (84) N--------AYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEK-SRVKCDQYWPV----RGTETYGLIQVTL-VDTVE-LATYTMRTFALHKSGSSEKRE-----------LRQFmLAR_D1 (NP_035343) Ptprf (84) N--------AYIATQGPLPETMGDFWRMVWEQRIATVVMMTRLEEK-SRVKCDQYWPA----RGTETYGLIQVTL-VDTVE-LATYTMRTFALHKSGSSEKRE-----------LRQFrLAR_D1 (NP_062122) Ptprf (84) N--------AYIATQGPLPETITDFWRMMWEQRTATIVMMTRLEEK-SRVKCDQYWPS----RGSETYGMIQVTL-MDTVE-LATYTVRTFTVYKNGSNEKRD-----------VRQFxLAR_D1 (AAF43606) (84) N--------AYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEER-SRVKCDQYWPS----RGTETHGLVQVTL-LDTVE-LATYCVRTFALYKNGSSEKRE-----------VRQFhPTPdelta _D1 (NP_002830) PTPRD (84) N--------AYIATQGSLPETFGDFWRMIWEQ-EATVVMMTKLEER-SRVKCDQYWPS----RGTETHGLVQVTL-LDTVE-LT-YCVRTFALYNNGSSEKRK-----------VRQFmPTPdelta_D1 (D54689) (84) N--------AYIATQGPLPETFGDFWRMMWEQRSATVVMMTKMEER-SRIKCDQYWPS----RGTETYGLIQVTL-LDTVE-LATYTVRTFALYKNGSSEKRE-----------VRQFxPTPdelta_D1 (AAF43605) (84) R--------HYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEV-GRVKCVRYWPD-----DTEVYGDIKVTL-IETEP-LAEYVIRTFTVQKKGYHEIRE-----------LRLFhPTPrho_D1 (NP_573400) PTPRT (84) R--------HYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEV-GRVKCVRYWPD-----DTEVYGDIKVTL-IETEP-LAEYVIRTFTVQKKGYHEIRE-----------LRLFmPTPrho_D1 (NP_067439) Ptprt (84) R--------YYIATQGPMQETVKDFWRMIWQENSISVVMVTNLVEV-GRVKCVRYWPD-----DTEVYGDIKVSA-IETEP-LAEYIIRTFTVQKKGSHEIRE-----------IRQFxPTPrho_D1 (AAD50295) (84) N--------HYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEV-GRVKCCKYWPD-----DTEIYKDIKVTL-IETEL-LAEYVIRTFAVEKRGVHEIRE-----------IRQFhPTPmu_D1 (NP_002836) PTPRM (84) N--------HYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEV-GRVKCCKYWPD-----DTEIYKDIKVTL-IDTEL-LAEYVIRTFAVEKRGIHEIRE-----------IRQFmPTPmu_D1 (NP_033010) Ptprm (84) S--------HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEV-GRVKCYKYWPD-----DTEVYGDFKVTC-VEMEP-LAEYVVRTFTLERRGYNEIRE-----------VKQFhPTPkappa_D1 (NP_002835) PTPRK (84) S--------HYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEV-GRVKCYKYWPD-----DTEVYGDFKVTC-VEMEP-LAEYVVRTFTLERRGYNEIRE-----------VKQFmPTPkappa_D1 (NP_033009 (revised)) Ptprk (84) N--------HFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEV-GRVKCSRYWPE-----DSDTYGDIKIML-VKTET-LAEYVVRTFALERRGYSARHE-----------VRQFhPTPlamda_D1 (NP_005695) PTPRU (80) N--------HFIATQGPKPEMIYDFWRMVWQEQCASIVMITKLVEV-GRVKCSRYWPE-----DSDMYGDIKITL-VKTET-LAEYVVRTFALERRGYSARHE-----------VRQFmPTPlamda_D1 (NP_035344) Ptprl (80) N--------HFIATQGPKPEMIYDFWRMVWQEQCVSVVMISKLVEV-GRVKCSRYWPE-----HSDMYGDIKITL-VKTET-LAEYVVRTFALERRGYSARHE-----------VRQFrPTPpsi_D1 (AAB42210) Ptpru Fragm (80) N--------KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKER-KECKCAQYWPD----QGCWTYGNIRVSV-EDVTV-LVDYTVRKFCIQQVGDVTNKKPQ-------RLVTQFcPTPalpha_D1 (AAB04150) (85) N--------KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKER-KECKCAQYWPD----QGCWTYGNIRVSV-EDVTV-LVDYTVRKFCIQQVGDMTNRKPQ-------RLITQFhPTPalpha_D1 (NP_002827) PTPRA (85) N--------KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKER-KECKCAQYWPD----QGCWTYGNVRVSV-EDVTV-LVDYTVRKFCIQQVGDVTNRKPQ-------RLITQFmPTPalpha_D1 (AAK56109) Ptpra (85) N--------KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKER-KECKCAQYWPD----QGCWPYGNVRVSV-EDVTV-LVDYTVRKFCIQQVGDVTNRKPQ-------RLITQFrPTPalpha_D1 (NP_036895) Ptpra (85) N--------KFIAAQGPKEETVNDYWRMIWEQNTATIVMVTNLKER-KECKCAQYWPD----QGCWTYGNIRVSV-EDTMI-LVDYTIRKFCIQQVGDVSGKKPQ-------RLVTQFzPTPalpha_D1 (NP_571963) ptpra (85) N--------KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKER-KECKCAQYWPD----QGCWTYGNIRVSV-EDMTV-LVDYTVRKFCIQQVGDVTNKKPQ-------RLITQFxPTPalpha_D1 (AAA17990) (85) N--------KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKER-KEEKCHQYWPD----QGCWTYGNIRVCV-EDCVV-LVDYTIRKFCIQPQLPDGCKAP--------RLVSQLhPTPepsilon_D1 (NP_006495) PTPRE (85) N--------KFIAAQGPKQETVNDFWRMVWEQRSATIVMLTNLKER-KEEKCYQYWPD----QGCWTYGNIRVCV-EDCVV-LVDYTIRKFCIHPQLPDSCKAP--------RLVSQLmPTPepsilon_D1 (NP_035342) Ptpre (85) N--------KFIAAQGPKQETVNDFWRMVWEQRSATIVMLTNLKER-KEEKCYQYWPD----QGCWTYGNIRVCV-EDCVV-LVDYTIRKFCIHPQLPDSCKAP--------RLVSQLrPTPepsilon_D1 (XP_215102) Ptpre (85) K--------AYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEK-GRRKCDQYWPT----ENSEEYGNIIVTL-KSTKI-HACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYhPTPgamma_D1 (NP_002832) PTPRG (89) K--------AYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNLVEK-GRRKCDQYWPT----ENTEEYGNIIVTL-KSTKV-HACYTVRRLSVRNTKVKKGQKGNPKGRQNERTVIQYmPTPgamma_D1 (NP_033007) Ptprg (89) K--------AYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNLVEK-GRRKCDQYWPT----ENTEEYGNIIVTL-KSTEV-HACYTVRRFSVRNTKVKKGQKGNPKGRQNERTVIQYrPTPgamma _D1 (NP_599183) Ptprg (93) K--------AYIATQGPLKSTFEDFWRMIWAQHTGIIVMITNLVEK-GRRKCDQYWPT----ENSEEYGNIIVTL-KSTNI-HACYTVRPLHGQEHKDEKGSERKPKGRQNERTVIQYcPTPgamma_D1 (Q98936) (89) K--------AYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEK-GRRKCDQYWPA----DGSEEYGNFLVTQ-KSVQV-LAYYTVRNFTLRNTKIKKGSQ---KGRPSGRVVTQYhPTPzeta_D1 (NP_002842) PTPRZ1 (94) K--------AYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEK-GRRKCDQYWPT----DGSEEYGSFLVNQ-KNVQV-LAYYTVRNFTLRNTKIKKGSQ---KGRSSGRLVTQYrPTPzeta_D1 (NP_037212) Ptprz1 (94) K--------AYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLLEK-GRRKCDQYWPA----EGSEEYGNFLVTQ-KSVHV-LAYYTVRNFTLRNTKIKKGSQ---KGRSSGRVVTQYcPTPzeta_D1 (AAA49015) (87) K--------AYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEK-GRRKCDQYWPS----DGSEEYGAFLVTQ-KTIKV-LAYYTVRTFTVRNNKIKKGSQ---KGRQNERAVVQYxPTPzeta_D1 (BAA97445) (87) R--------KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEG-NRNKCAEYWPSME--EGTRAFGDVVVKINQHKR--CPDYIIQKLNIVNKKEKA----------TGREVTHIhCD45_D1 (NP_002829) PTPRC (85) R--------KYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEG-NRNKCAEYWPSME--EGTRAFKDIVVTINDHKR--CPDYIIQKLNVAHKKEKA----------TGREVTHImCD45_D1 (NP_035340) Ptprc (85) R--------KYIAAQGPRDETVDDFWKMIWEQKATVIVMVTRCEEG-NRNKCAEYWPCME--EGTRTFRDVVVTINDHKR--CPDYIIQKLSIAHKKEKA----------TGREVTHIrCD45_D1 (XP_213985) Ptprc (85) R--------KYIAAQGPKDETTDDFWRMIWEQKATIIVMVTRCEEG-NRNKCAQYGPSME--NGSATYGDITVKINESKI--CPDYIIQKLHITNGRERT----------SGRDVTHIcCD45_D1 (A54080) (85) K--------KYIAAQGPKDETVVDFWRMVWEQKSSIIVMVTRCEEG-NKTKCAQYWPSLD--REAEIFEEFVVKIRSEEH--CPDYVIRHLILNNKREKG----------SEREVTHIcypcaCD45_D1 (BAA92179) (82) K--------KYIAAQGPKEETVSNFWRMIWEQQTSIIVMVSRCEEG-NRIKCAQYWPSED--RDTEIFEEFIVKLTSEDH--YPDYIIRHLSLTNKKDKG----------SEREVTHIfuCD45_D1 (CAB96211) (85) R--------KYIAAQGPKEETSDDFWKMVWEQKATIIVMVTRCEEG-KRPKCAQYWPTMD--SPSKTFGDLTVRISEEQW--CPDYVIRKLFISHKSEKT----------PEREVTHIsharkCD45_D1 (T43148) (85) K--------DFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQ-GRTKCEEYWPS----KQAQDYGDITVAMTSEIVL--PEWTIRDFTVKNIQT-----------SESHPLRQFhDEP1_D1 (NP_002834) PTPRJ (84) K--------DFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQ-GRTKCEEYWPS----KQAQDYGDITVAMTSEVVL--PEWTIRDFVVKNMQS-----------SESHPLRQFrDEP1_D1 (NP_058965) Ptprj (84) K--------DFIATQGPLPNTLKDFWRMVWEKNVYAIVMLTKCVEQ-GRTKCEEYWPS----KQAQDYGDITVAMTSEVVL--PEWTIRDFVVKNMQN-----------SESHPLRQFmDEP1_D1 (NP_033008) Ptprj (84) Q--------EYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEK-RRVKCDHYWPFT---EEPIAYGDITVEMISEEEQ--DDWACRHFRINYA-------------DEMQDVMHFhGLEPP1_D1 (NP_109592) PTPRO (85) Q--------EYIATQGPLPETRNDFWKMVLQQKSRIIVMLTQCNEK-RRVKCDHYWPFT---EEPIAYGDITVEMVSEEEQ--EDWASRHFRINYA-------------DEAQDVMHFrGLEPP1_D1 (NP_059032) Ptpro (85) Q--------EYIATQGPLPETRNDFWKMVLQQKSHIIVMLTQCNEK-RRVKCDHYWPFT---EEPIAYGDITVEMVSEEEE--EDWASRHFRINYA-------------DEAQDVMHFmPTPphi_D1 (NP_035346) Ptpro (85) Q--------EYIATQGPLPETRNDFWKMVLQQKSQMIVMLTQCNEK-RRVKCDHYWPFT---EEPIAYGDITVEMISEEEQ--DDWAHRHFRINYA-------------DEMQDVMHFrabPTPoc_D1 (AAB16824) (85) R--------EYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEK-GRVKCDHYWPAD---QDSLYYGDLILQMLSESVL--PEWTIREFKICGEEQL----------DAHRLIRHFhPTPbeta_D1 (NP_002828) PTPRB (85) R--------EYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEK-GRVKCDHYWPAD---QDPLYYGDLILQMVSESVL--PEWTIREFKICSEEQL----------DAHRLIRHFmPTPbeta_D1 (NP_084204) Ptprb (85) R--------EYIATQGPLPGTKDDFWKMAWEQNVHNIVMVTQCVEK-GRVKCDHYWPAD---QDPLYYGDLILQMVSESVL--PEWTIREFKICSEEQL----------DAHRLLRHFrPTPbeta_D1 (XP_235156 (revised)) (85) N--------EFIATQGPLPGTVGDFWRMVWETRAKTLVMLTQCFEK-GRIRCHQYWPEDN--KPVTVFGDIVITKLMEDVQ--IDWTIRDLKIERH-------------GDCMTVRQChPTPS31_D1 (AR073855) PTPGMC1 (85) N--------EFIATQGPLPGTVGDFWRMVWETRTKTLVMLTQCFEK-GRIRCHQYWPEDN--KPVTVFGDIVITKLMEDIQ--IDWTIRDLKIERH-------------GDCMTVRQCrPTPGMC1_D1 (NP_075214) Ptprq (85) Q--------EFIATQGPLPQTVGDFWRLVWEQQSHTLVMLTNCMEA-GRVKCEHYWPLDS---QPCTHGHLRVTLVGEEV--MENWTVRELLLLQVE-----------EQKTLSVRQFhSAP1_D1 (NP_002833) PTPRH (85) K--------EFIATQGPLPNTVGDFWRMVWEQQSHTLVMLTNCMES-GRVKCEHYWPLDA---QPCIHGQLQVMLISEEA--SENWTVRHLQLFHMK-----------EQQTLSLRQFmSAP1_D1 (BAC37443) (85) K--------EFIATQGPLPHTVSDFWRMVWEQQSHTLVMLANCMES-GQVKCEHYWPLDA---QPCTHGQLQVTLVSEEV--TENWTVRHLQLFHMK-----------EQQTLSVRQFrPTPBEM2_D1 (NP_598276) (85) Q--------EIIATQGPLKKTVEDFWRLVWEQQVHVIIMLTVGMEN-GRVLCEHYWPVNS---TPVTHGHITTHLLAEES--EDEWTRREFQLQHGA-----------EQKQRRVKQLmPTPESP_D1 (NP_031981) Esp (85)

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VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

Q--------EIIATQGPLKKTLEDFWRLVWEQQVHVIIMLTVGMEN-GRVLCEHYWPANS---TPVTHGHITIHLLAEEP--EDEWTRREFQLQHGT-----------EQKQRRVKQLrOSTPTP_D1 (NP_149090) Esp (85) E-------KAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKE--KNEKCVLYWPE-----KRGIYGKVEVLVISVNE--CDNYTIRNLVLKQ-------------GSHTQHVKHYhPCPTP1_D1 (NP_002840) PTPRR (85) E-------KAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKE--KNEKCVLYWPE-----KRGIYGKVEVLVIGVNE--CDNYTIRNLVLKR-------------GSHTQHVKHYrPCPTP1_D1 (NP_446046) Ptprr (85) E-------KAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKE--KNEKCVLYWPE-----KRGIYGKVEVLVTGVTE--CDNYTIRNLVLKQ-------------GSHTQHVKHYmPTPSL_D1 (NP_035347) Ptprr (85) E-------KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE--MNEKCTEYWPE-----EQVAYDGVEITVQKVIH--TEDYRLRLISLKS-------------GTEERGLKHYhSTEP_D1 (NP_116170) PTPN5 (85) E-------KVYIATQGPIVSTVADFWRMVWQERTPIIVMITNIEE--MNEKCTEYWPE-----EQVVHDGVEITVQKVIH--TEDYRLRLISLRR-------------GTEERTLKHYmSTEP_D1 (NP_038671) Ptpn5 (85) E-------KVYIATQGPIVSTVVDFWRMVWQERTPIIVMITNIEE--MNEKCTEYWPE-----EQVVHDGVEITVQKVIH--TEDYRLRLISLRR-------------GTEERGLKHYrSTEP_D1 (NP_062126) Ptpn5 (85) E-------KVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLRE--GKEKCVHYWPT-----EEETYGPFQIRIQDMKE--CPEYTVRQLTIQY-------------QEERRSVKHIhHePTP_D1 (NP_002823) PTPN7 (83) E-------KVYIATQGPMPNTVADFWEMVWQEDVSLIVMLTQLRE--GKEKCVHYWPT-----EEEAYGPFQIRIQDMKE--HPEYTVRQLTIQH-------------QQECRSVKHImHePTP_D1 (NP_796055) Ptpn7 (83) E-------KVYIATQGPMPNTVADFWEMVWQEDVSLIVMLTQLRE--GKEKCVHYWPT-----EEEAYGPFQIRIQGMKE--HPEYTVRHLTIQH-------------QQECRSVKHIrLCPTP_D1 (P49445) Ptpn7 (83) K--------AYIATQGPLSTTLLDFWRMIWEYSVLIIGMACMEYEM-GKKKCERYWAEPV--EMQLEFGPFSVSCEAEKRK--SDYIIRTLKVKFN-------------SETRTIYQFhLyPTP_D1 (NP_057051) PTPN22 (93) K--------AYIATQGPLSTTLLDFWRMIWEYRILVIVMACMEFEM-GKKKCERYWAEPG--ETQLQFGPFSISCEAEKKK--SDYKIRTLKAKFN-------------NETRIIYQFmPEP_D1 (NP_033005) Ptpn8 (93) K--------AYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEM-GRKKCERYWPLYG--EDPITFAPFKISCEDEQAR--TDYFIRTLLLEFQ-------------NESRRLYQFhPEST_D1 (NP_002826) PTPN12 (97) R--------AYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEM-GRKKCERYWPLYG--EDPITFAPFKISCENEQAR--TDYFIRTLLLEFQ-------------NESRRLYQFrRKPTP_D1 (NP_476456) Ptpn12 (97) K--------AYVATQGPFRNTVIDFWRMIWEYNVVMIVMACREFEM-GRKKCERYWPLYG--EDPITFAPFKISCENEQAR--TDYFIRTLLLEFQ-------------NESRRLYQFmPEST_D1 (NP_035333) Ptpn12 (97) L--------AYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIEN-GRKRCERYWAQE---QEPLQTGLFCITLIKEKWL-NEDIMLRTLKVTFQ-------------KESRSVYQLhBDP1_D1 (NP_055184) PTPN18 (94) Q--------AYIATQGPLPHTLLDFWRLVWEFGVKVILMACQETEN-GRRKCERYWARE---QEPLKAGPFCITLTKETTL-NADITLRTLQVTFQ-------------KEFRSVHQLmPTPK1_D1 (NP_035336) Ptpn18 (94) Q--------AYIATQGPLPHTLLDFWRLVWEFGIKVILMACQETEN-GRRKCERYWAQE---REPLQAGPFCITLTKETAL-TSDITLRTLQVTFQ-------------KESRPVHQLrPTP20_D1 (AAC52896) (94) PDEN---AKTYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEK-GRNKCVPYWPE---VGMQRAYGPYSVTNCGEHD--TTEYKLRTLQVSPLDNGDLIR----------EIWHYhSHP1_D1 (NP_002822) PTPN6 (94) PDEN---SKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEK-GRNKCVPYWPE---VGTQRVYGLYSVTNSREHD--TAEYKLRTLQISPLD----NGDLVR------EIWHYmSHP1_D1 (NP_038573) Hcph (94) PDEN---SKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEK-GRNKCVPYWPE---VGTQRVYGLYSVTNCKEHD--TAEYKLRTLQISPLD----NGDLVR------EIWHYrSHP1_D1 (NP_446360) Ptph6 (94) TNPQ----KTYIACQGCLATTVDDFWQMMWQEDSRVIVMTTREVEK-GRNKCVPYWPT--TEGESKEVGRYVVKLLSEMD--AADYKVRVVELTAPH----RNEAPR------KIWHFzSHP1_D1 (AAH44414) (94) DD-----CKNYIATQGCLQNTINDFWKMIYQENAHVIVMTTKEIER-GKCKCVRYWPD---VKTSTEYGMISVRNLEERM--AQDYIVRDLEVMRLD----WNERPR------HVWHYryPTPN6c_D1 (BAA95199) (65) KCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER-GKSKCVKYWPD---EYALKEYGVMRVRNVKESA--AHDYTLRELKLSKVG----QGNTER------TVWQYhSHP2_D1 (NP_002825) PTPN11 (94) KCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER-GKSKCVKYWPD---EYALKEYGVMRVRNVKESA--AHDYTLRELKLSKVGQALLQGNTER------TVWQYmSHP2_D1 (NP_035332) Ptpn11 (94) KCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER-GKSKCVKYWPD---ECALKEYGVMRVRNVRESA--AHDYTLRELKLSKVG----QGNTER------TVWQYrSHP2_D1 (NP_037220) Ptpn11 (94) KCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER-GKSKCVKYWPD---EYSLKEYGVMRVRNVKESA--AHDYTLRELKLSKVG----QGNTER------TVWQYcSHP2_D1 (JC5167) (94) KSNNSKLKRSYIATQGCLQNTISDFWRMVFQENSRVIVMTTKEVER-GKSKCVKYWPD---VSALKEYGAMRVRNVKETM--AHDYILRELKLSKVG----QGNTER------TVWQYzSHP2_D1 (AAH45328) (94) KCINPKPKKRYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER-GKSKCVKYWPD---EFALKEYGVMRVRNVKETP--AHDYILRELKLSKVG----QGNTER------AVWQYxSHP2_D1 (A55651) (94) NRTTTKPKKTYIATQGCLHDTVNDFWRMVFQENSRVIVMTTKEVER-GKSKCVKYWPD---EMSSKEYGAMRVKNVRENP--AHDYILRELKLSKVG----QGSTER------TVWQYryPTPN6b_D1 (BAA95198) (65) IE------WDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEG-GREKSFRYWPRLGSRHNTVTYGRFKITTRFRTD--SGCYATTGLKMKHLLTG-----------QERTVWHLhPTPD1_D1 (NP_008970) PTPN21 (86) IE------WDYIATQGPLQNTCQDFWQMVWEQGVAIIAMVTAEEEG-GREKSFRYWPRLGSRHNTVTYGRFKITTRFRTD--SGCYATTGLKMKHLLTG-----------QERTVWHLmPTPRL10_D1 (NP_036007) Ptpn21 (86) IE------WDYIATQGPLQNTCQDFWQMVWEQGVAIIAMVTAEEEG-GREKSFRYWPRLGSRHNTVTYGRFKITTRFRTD--SGCYATTGLKMKHLLTG-----------QERTVWHLrPTP2E_D1 (NP_598229) Ptp2E (86) AE------WHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEG-GRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTD--SVCYATTGLKVKHLLSG-----------QERTVWHLhPTPD2_D1 (NP_005392) PTPN14 (85) SE------WHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEEG-GRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTD--SGCYATTGLKVKHLLSG-----------QERTVWHLmPTP36_D1 (NP_033002) Ptpn14 (85) SE------WHYIATQGPLPHTCHDFWQMVWEQGVNVIAMVTAEEAG-GRTKSHRYWPKLGSKHSSATYGKFKVTTKFRTD--SGCYATTGLKVKHLLSG-----------QERTVWHLrPTPD2_D1 (XP_223062 (revised)) (85) SS----IINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVER-GRVKCHQYWPEP---TGSSSYGCYQVTCHSEEG--NTAYIFRKMTLFNQEKN-----------ESRPLTQIhMEG1_D1 (NP_002821) PTPN4 (81) SS----IINQYIACQGPLPHTCKDFWQMIWEQGSSMVVMLTTQVER-GRVKCHQYWPEP---SESSSYGCYQATCHSEEG--NPAYIFRKMTLINQEKN-----------ESRQLTQImMEG1_D1 (NP_064317) Ptpn4 (81) CS----LINRYIACQGPLPNTCSDFWQMTWEQGSSMVVMLTTQV------KCHQYWPNP---SGSATYGGFQISCQTEEG--NSAFLVREITLTHIESG-----------ESRELTQIzMEG1_D1 (CAD43435) (81) AN----LVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTER-GRTKCHQYWPDP---PDVMNHGGFHIQCQSEDC--TIAYVSREMLVTNTQTG-----------EEHTVTHLhPTPH1_D1 (NP_002820) PTPN3 (81) AN----LVNKYIATQGPLPNTCAQFWQVVWDQKLSLVVMLTTLTER-GRTKCHQYWPDP---PDIMDHGIFHIQCQTEDC--TIAYVSREMLVTNTETG-----------EEHTVTHLmPTPH1_D1 (XP_143789) Ptpn3 (81) EE------FVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEG-EKIKCQRYWP-NILGKTTMVSNRLRLALVRMQQ--LKGFVVRAMTLEDIQTR-----------EVRHISHLhPTPBAS_D1 (NP_006255) PTPN13 (81) QE------FVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEG-EKIKCQRYWP-SILGTTTMANERLRLALLRMQQ--LKGFIVRVMALEDIQTG-----------EVRHISHLmPTPBL_D1 (NP_035334) Ptpn13 (81) EE------FVYIACQGPLPTTVGDFWQMIWEQNSSVIAMMTQEVEG-EKIKCQRYWP-NVLGKSTMVSNRLRLALVRVQQ--LKGFVVRAMTLEDIQTG-----------EVRHVSHLbPTPBA14_D1 (NP_777015) PTPN13 (81) EE------YFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREMEG-GIIKCYHYWP--ISLKKPLELKHFRVFLENYQI--LQYFIIRMFQVVEKSTG-----------TSHSVKQLhPTPTyp_D1 (AL050040) PTPN20 (81) EE------YFYIATQGPLPETIEDFWQMVLENNCNVIAMITREIEC-GVIKCYSYWP--ISLKEPLEFEHFSVFLETFHV--TQYFTVRVFQIVKKSTG-----------KSQCVKHLmPTPTyp_D1 (NP_033004) Ptpn20 (80) R--------SYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK-GSIKCAQYWPRKEEKEMFFEDTNLKLTLISEDI--KSYYTVRQLELENLTTQ-----------ETREILHFcPTP1B_D1 (O13016) (79) R--------SYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEK-GSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDI--KSYYTVRQLELENLTTQ-----------ETREILHFhPTP1B_D1 (NP_002818) PTPN1 (79) R--------SYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEK-GSLKCAQYWPQQEEKEMVFDDTGLKLTLISEDV--KSYYTVRQLELENLTTK-----------ETREILHFmPTP1B_D1 (NP_035331) Ptpn1 (79) R--------SYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEK-GSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDV--KSYYTVRQLELENLATQ-----------EAREILHFrPTP1B_D1 (NP_036769) Ptpn1 (79) R--------KYILTQGPLPNTCGHFWEMVWEQRSRGVVMLNRVIEK-GSVKCAQYWPQREEREAVFEDTNFRLTLISEDV--KSYYTVRQLELENLSTQ-----------ETREILHFzPTP1B_D1 (NP_570999) ptp1b (77) R--------SYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEK-ESVKCAQYWP-TDDQEMLFKETGFSVKLLSEDV--KSYYTVHLLQLENINSG-----------ETRTISHFhTCPTP_D1 (NP_002819) PTPN2 (79) R--------SYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRTVEK-ESVKCAQYWP-TDDREMVFKETGFSVKLLSEDV--KSYYTVHLLQLENINTG-----------ETRTISHFmTCPTP_D1 (NP_033003) Ptpn2 (79) R--------SYILTQGPLPNTCCHFWLMVWQQKTRAVVMLNRTVEK-ESVKCAQYWP-TDDREMVFKETGFSVKLLSEDV--KSYYTVHLLQLENINSG-----------ETRTISHFrTCPTP_D1 (NP_446442) Ptpn2 (79) R--------RYILTQGPLRNTCGHFWLMIWEQKTKAVIMLNRVIEK-GSEKCAQYWPTQEEREMSFRDTRFVVTLVSEDV--KSYYTTRVLELQNANTG-----------ETREIYHFzTCPTP_D1 (AAH44373) (77) N--------AYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEG-GRRKCGQYWP--LEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLEIHNTEER-----------QKRQVTHFhMEG2_D1 (NP_002824) PTPN9 (85) N--------AYNGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEG-GRRKCGQYWP--LEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLEIHNTEER-----------QKRQVTHFmMEG2_D1 (NP_062625) Ptpn9 (85) N--------AYIATQGPLPKTFDDFWRMVWEQKVLIIVMTTRVIER-GRIKCGQYWP--LEAGRSEDTGHFIIRNIHIDL--FQDFKLTHFEVYNKQTD-----------ESRSVAHYxPTPX10_D1 (B53978) (85) N--------AYIATQGPLPKTFDDFWRMVWEQKVLIIVMTTRVIER-GRIKCGQYWP--LEAGRSEDTGHFIIRNIHIDL--FQDFKLTHLEVYNKQTD-----------ESQSVAHYxPTPX1_D1 (AAH43621) (85) CP-------PLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEM-EKQKVARYFP--TERGQPMVHGALSLALSSVRS--TETHVERVLSLQFRDQS-----------LKRSLVHLhHDPTP_D1 (NP_056281) PTPN23 (88) CP-------PLVATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEM-EKQKVARYFP--TERGQPMVHGALSVALSSIRT--TETHVERVLSLQFRDQS-----------LKRSLVHLmHDPTP_D1 (AAH22721) (88) CP-------PLVATQRPLPGTAADFWLMVHEQKVSVIVMLVSEAEM-EKQKVARYFP--IERGQPMVHGALSVALSSVRT--TDTHVERVLSLQFRDQS-----------LKRSLVHLrPTPTD14_D1 (T14355) (88) MP-------AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVED-GVKQCDRYWP----DEGASLYHVYEVNLVSEHIW-CEDFLVRSFYLKNVQT-----------QETRTLTQFhIA2_D1 (NP_002837) PTPRN (85) MP-------AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVED-GVKQCDRYWP----DEGSSLYHVYEVNLVSEHIW-CEDFLVRSFYLKNVQT-----------QETRTLTQFmIA2_D1 (NP_033011) Ptprn (85) MP-------AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVED-GVKQCDRYWP----DEGSSLYHVYEVNLVSEHIW-CEDFLVRSFYLKNVQT-----------QETRTLTQFrIA2_D1 (NP_446333) Ptprn (85)

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Page 6: Alignment 195 Vert PTP Domainsptp.cshl.edu/downloads/ptp_alignment_files/...VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

MP-------AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVED-GVKQCDRYWP----DEGSSLYHVYEVNLVSEHIW-CEDFLVRSFYLKNVQT-----------QETRTLTQFbIA2_D1 (P56722) Ptprn (85) NP-------AYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAEN-GVRQCYHYWP----DEGSNLYHIYEVNLVSEHIW-CEDFLVRSFYLKNLQT-----------NETRTVTQFhIA2beta_D1 (NP_002838) PTPRN2 (85) NP-------AYIATQGPLPATVADFWQMVWESGCVVIVMLTPLTEN-GVRQCYHYWP----DEGSNLYHIYEVNLVSEHIW-CEDFLVRSFYLKNLQT-----------NETRTVTQFmacneIA2beta_D1 (O02695) (85) NP-------AYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSEN-GVRQCHHYWP----DEGSNLYHVYEVNLVSEHIW-CQDFLVRSFYLKNLQT-----------NETRTVTQFmPTPNP_D1 (P80560) Ptprn2 (85) NP-------AYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSEN-GVRQCHHYWP----DEGSNVYHVYEVNLVSEHIW-CQDFLVRSFYLKNLQT-----------NETRTVTQFrPTPNE6_D1 (NP_113788) Ptprn2 (85) E--------VMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHG-DQEICAQYWGE-----GKQTYGDIEVDLKDTDK--SSTYTLRVFELRHSKRK-----------DSRTVYQYhCD45_D2 (NP_002829) PTPRC (108) E--------MMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELVNG-DQEVCAQYWGE-----GKQTYGDMEVEMKDTNR--ASAYTLRTFELRHSKRK-----------EPRTVYQYmCD45_D2 (NP_035340) Ptprc (108) E--------MMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELMSG-DQEVCAQYWGE-----GKQTYGDMEVMLKDTNK--SSAYILRAFELRHSKRK-----------EPRTVYQYrCD45_D2 (XP_213985) Ptprc (108) K--------AMIATQGPLQETISDFWQMVFQRKVKVIVMLTELKEG-DQELCAQYWGE-----GRQTYDDIEVQVTDVNC--CPSYTIRAFDVTHLKRK-----------ETQKVYQYcCD45_D2 (A54080) (108) H--------TFISAQTPLPDTVADFWSMILQKRVSIVVMLSDCSQG---DEDCVYWGE-----DKKTVEDIEVETESTDN--SPNFILRNMMIHHLKTD-----------AHQQVKHFfuCD45_D2 (CAB96211) (110) K--------SLIAAQGPLQSTAEEFLLMLYQQQTKTLVMLTDCQED-GKDYCFQYWGD-----EKKTYGDMEIEVKKTET--FPTYVRRHLEIQSLKKK-----------EVLKVDQYcypcaCD45_D2 (BAA92179) (106) E--------VMIAAQGPLXETIGDFWQMIFQRKVKVIVMLTELKHG-DQEICAQYWGE-----GKQTYGDIEVDLKDTDK--SSTYTLRVFELRHSKRK-----------DSRTVYQYaotvoCD45_D2 (AAM48512) (3') (100) E--------TLIATQTPLPETIADFWMMVYQRKARIIAMLGKLKD---DKDCSQYWED-----DKKTYDDIEVVLSECNK--QPEFIVRIFEIRHTKRK-----------ETRQVYQYsharkCD45_D2 (T43148) (109) T---------PTCQPRPVQHTIEDFWRMIWEWKSCSIVMLTELEER-GQEKCAQYWPS----DGSVSYGDINVELKKEEE--CESYTVRDLLVTNTREN-----------KSRQIRQFcPTPalpha_D2 (AAB04150) (90) D--------SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEER-GQEKCAQYWPS----DGLVSYGDITVELKKEEE--CESYTVRDLLVTNTREN-----------KSRQIRQFhPTPalpha_D2 (NP_002827) PTPRA (90) D--------SYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEER-GQEKCAQYWPS----DGLVSYGDITVELKKEEE--CESYTVRDLLVTNTREN-----------KSRQIRQFmPTPalpha_D2 (NP_033006) Ptpra (90) D--------SYIASQGPLLHTTEDFWRMIWEWKSCSIVMLTELEER-GQEKCAQYWPS----DGLVSYGDITVELKKEEE--CESYTVRDLLVTNTREN-----------KSRQIRQFrPTPalpha_D2 (NP_036895) Ptpra (90) D--------SYIAGQGPLRHSLEDFWRMIWEWKSCSIVMLTELEER-GQEKCAQYWPS----EGTMSFGDITIELKKEEE--SESYTVRDMFVTNTREN-----------KSRQIRQFxPTPalpha_D2 (AAA17990) (90) D--------SYMACQGPLQHTIEDYWRMIWEWRSCSIVMLTELEER-GQEKCAQYWPT----DGVMVCGDMSIELKREEE--SESYTVRDLLVTNNREN-----------KSRAVRQFzPTPalpha_D2 (NP_571963) ptpra (90) D--------SYIASQGPLQHTIEDFWRMIWEWKSCSIVMLTELEER-GQEKCAQYWPS----EGTVTYGDITIEIKKEEE--SESYTVRDLLVTNTREN-----------KVRQIRQFryPTPR4b_D2 (BAA95196) (90) D--------YFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQER-EQDKCYQYWPT----EGSVTHGEITIEIKNDTL--SEAISIRDFLVTLNQPQARQE------EQVRVVRQFhPTPepsilon_D2 (NP_006495) PTPRE (90) D--------YFMATQGPLAHTGEDFWRMVWEWKSHTIVMLTEVQER-EQDKCYQYWPT----EGSVTHGDITIEIKSDTL--SEAISVRDFLVTFKQPLARQE------EQVRMVRQFmPTPepsilon_D2 (NP_035342) Ptpre (90) D--------YFMATQGPLAHTVEDFWRMVWEWKSHTIVMLTEVQER-EQDKCYQYWPT----EGSVTHGDITIEIKSDTL--SEAISIRDFLVTFKQPLARQE------EQVRMVRQFrPTPepsilon_D2 (XP_215102) Ptpre (90) D--------YFIATQGPLSHTVEDFWRMVWEWRCHSIVMLTELKER-EQEKCFQYWPS----EGSVIFGDYAVELTGESQ--GETFTRKDMLLTYKSCLSQQE------KQPQHVRHForylaPTPepsilon_D2 (BAC06424) (90) D--------YFVATQGPLAHTVEDFWRMVWDCKSHTIVMLTELRER-EQEKCCQYWPS----EGSVTYGTYSTELKKDNI--TDAFSLRDLTVTNTTEN-----------IERTVRQFryPTPR4a_D2 (BAA95190) (90) A--------AFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL---SQGCPQYWPE----EGMLRYGPIQVECMSCSM--DCDVINRIFRICNLTRPQ---------EGYLMVQQFhPTPkappa_D2 (NP_002835) PTPRK (88) A--------AFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL---SQGCPQYWPE----EGMLRYGPIQVECMSCSM--DCDVINRIFRICNLTRPQ---------EGYLMVQQFmPTPkappa_D2 (NP_033009) Ptprk (88) A--------AFIVTQHPLPNTVKDFWRLVYDYGCTSVVMLNELDL---VQGCPQYWPE----EGTLRYGPIQVDCVSCSM--DCDLVSRLFRICNLTRPQ---------EGYLMVQQFryPTPR2B_D2 (BAA95194) (88) A--------AFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPE----PGRQQYGLMEVEFMSGTA--DEDLVARVFRVQNISRLQ---------EGHLLVRHFhPTPlamda_D2 (NP_005695) PTPRU (88) A--------AFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPE----PGRQQYGLMEVEFVSGTA--NEDLVSRVFRVQNSSRLQ---------EGHLLVRHFmPTPlamda_D2 (NP_035344) Ptprl (88) S--------AFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP---AQLCPQYWPE----NGVHRHGPIQVEFVSADL--EEDIISRIFRIYNAARPQ---------DGYRMVQQFhPTPmu_D2 (NP_002836) PTPRM (88) S--------AFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP---AQLCPQYWPE----NGVHRHGPIQVEFVSADL--EEDIISRIFRIYNASRPQ---------DGHRMVQQFmPTPmu_D2 (NP_033010) Ptprm (88) S--------AFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDP---TQLCPQYWPE----NGVHRHGPIQVEFVSADL--EEDIISRIFRIYNASRPQ---------DGHRMVQQFrPTPmu_D2 (XP_237546 (revised)) (88) A--------AFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT---AQFCMQYWPE----KTSGCYGPIQVEFVSADI--DEDIIHRIFRICNMARPQ---------DGYRIVQHLhPTPrho_D2 (NP_573400) PTPRT (88) A--------AFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT---AQLCMQYWPE----KTSGCYGPIQVEFVSADI--DEDIIHRIFRICNMARPQ---------DGYRIVQHLmPTPrho_D2 (NP_067439) Ptprt (88) K--------AYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFcPTPsigma_D2 (I50212) (90) K--------AYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTIRQFhLAR_D2 (NP_002831) PTPRF (90) K--------AYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTIRQFmLAR_D2 (NP_035343) Ptprf (90) K--------AYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTIRQFrLAR_D2 (NP_062122) Ptprf (90) K--------GYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTIRQFxLAR_D2 (AAF43606) (90) K--------AYIATQGPLSETTEDFWRMLWEHNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTIRQFzLAR_D2 (CAC44758) (90) K--------AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYS--MPQYILREFKVTDARDG-----------QSRTIRQFryPTPR2Aa_D2 (BAA95188) (90) K--------AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFhPTPdelta_D2 (NP_002830) PTPRD (90) K--------AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARD------------QSRTVRQFmPTPdelta_D2 (D54689) (90) K--------AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFxPTPdelta_D2 (AAF43605) (90) K--------AYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFryPTPR2Ab_D2 (BAA95191) (90) K--------AYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFhPTPsigma_D2 (NP_002841) PTPRS (90) K--------AYIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFmPTPsigma_D2 (NP_035348) Ptprs (90) K--------AYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFxPTPsigma_D2 (AAF43607) (90) K--------AYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFzPTPsigma_D2 (CAC44759) (90) K--------AYIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFrPTPsigma_D2 (NP_062013) Ptprd (90) K--------AYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMG-REKCHQYWP----AERSARYQYFVVDPMAEYN--MPQYILREFKVTDARDG-----------QSRTVRQFryPTPR2Ac_D2 (BAA95193) (90) N--------EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQS--LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDD-----------YVLEVRHFhPTPgamma_D2 (NP_002832) PTPRG (89) N--------EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQS--LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDD-----------YVLEVRHFmPTPgamma_D2 (NP_033007) Ptprg (89) N--------EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQS--LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDD-------------------rPTPgamma_D2 (NP_599183) Ptprg (89) N--------EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNHG--LAEDESVYWPSREESMNCEAFTVTLISKDILCLSNEEQVIIHDFILEATQDD-----------YVLEVRHFryPTPR5b_D2 (BAA95197) (89) N--------ENVITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQS--LAEDEFVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDD-----------YVLEVRHFcPTPgamma_D2 (Q98936) (89) N--------EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN--MAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDD-----------YVLEVRHFhPTPzeta_D2 (NP_002842) PTPRZ1 (88) N--------EFIITQHPLLHTIKDFWRMIWDHNAQLIVMLPDSQN--MAEDEFVYWPNKDEPINCETFKVTMIAEEHKCLSKEEKLIIQDFILEATQDD-----------YVLEVRHFcPTPzeta_D2 (AAA49015) (88) N--------EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN--MAEDEFVYWPNKDEPINCESFKVTLMSEEHKCLSNEEKLIVQDFILEATQDD-----------YVLEVRHFmPTPzeta_D2 (XP_133009) Ptprz1 (88) N--------EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN--MAEDEFVYWPNKDEPINCESFKVTLMSEEHKCLSNEEKLIVQDFILEATQDD-----------YVLEVRHFrPTPzeta_D2 (NP_037212) Ptprz1 (88) N--------QFIITQHPLLHTIKDFWRMMWDHNSQLIVMLPDMQN--MAEDEFVYWPNKDQPIVCDTFTVTLVREDHVCLSNEENLIIQDFILEATQDD-----------YVLEVRHFxPTPzeta_D2 (BAA97445) (88) D--------EFIVTQHPLPYTTKDFWRMIWDYNAQIIVMLPDNQG------LTPYWPKKDGPMNYEAFTVSLLNESHLCLSNEEQLTIKDFILEATQDD-----------YVLEVRHYryPTPR5a_D2 (BAA95195) (88) YIATQGPL TV DFWRMVWE S VIVMLT L E R KC QYWP YG I V L E Y VR F L R V QFConsensus (119)

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Page 7: Alignment 195 Vert PTP Domainsptp.cshl.edu/downloads/ptp_alignment_files/...VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

Section 3237 354250 260 270 280 290 300 310 320 330 340(237) QFTAWPDHGVPEY--PTPFLAFLRRVKTCN-------------PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKP---EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGhPTPsigma_D1 (NP_002841) PTPRS (176) QFTAWPDHGVPEY--PTPFLAFLRRVKTCN-------------PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKT---EKTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEALLEAVGmPTPsigma_D1 (NP_035348(revised)) Ptprs (176) QFTAWPDHGVPEY--PTPFLAFLRRVKTCN-------------PPDAGPVVVHCSAGVGRTGCFIVIDAMLERIRT---EKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGrPTPsigma_D1 (NP_062013) Ptprd (176) QFTAWPDHGVPEY--PTPFLAFLRRVKTCN-------------PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAVAcPTPsigma_D1 (I50212) (176) QFTAWPDHGVPEY--PTPFLAFLRRVKTCN-------------PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAVAxPTPsigma_D1 (AAF43607) (176) QFTAWPDHGVPEY--PTPFLAFLRRVKTCN-------------PPDAGPIIAHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRSQRNYMVQTEDQYSFIHDALLEAVAzPTPsigma_D1 (CAC44759) (176) QFMAWPDHGVPEY--PTPILAFLRRVKACN-------------PLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH---EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAThLAR_D1 (NP_002831) PTPRF (176) QFMAWPDHGVPEY--PTPILAFLRRVKACN-------------PLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH---EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMmLAR_D1 (NP_035343) Ptprf (176) QFMAWPDHGVPEY--PTPILAFLRRVKACN-------------PLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH---EKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMrLAR_D1 (NP_062122) Ptprf (176) QFMAWPDHGVPEY--PTPILGFLRRVKACN-------------PPDAGPMFVHCSAGVGRTGCFIVIDAMLERVKL---EKTVDIYGHVTCMRSQRNYMVQTEDQYIFIHEALLEAVMxLAR_D1 (AAF43606) (176) QFTAWPDHGVPEH--PTPFLAFLRRVKTCN-------------PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVThPTPdelta _D1 (NP_002830) PTPRD (176) QFTAWPDHGVPEH--PTPFLAFLRRVKTCN-------------PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTmPTPdelta_D1 (D54689) (174) QFTAWPDHGVPEH--PTPFLAFLRRVKTCN-------------PPDAGPMVVHCSAGVGRTGCFNVIDAMLERIRH---EKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTxPTPdelta_D1 (AAF43605) (176) HFTSWPDHGVPCY--ATGLLGFVRQVKFLN-------------PPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAEN---EGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLhPTPrho_D1 (NP_573400) PTPRT (175) HFTSWPDHGVPCY--ATGLLGFVRQVKFLN-------------PPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAEN---EGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLmPTPrho_D1 (NP_067439) Ptprt (175) HFTSWPDNGVPCY--ATGLLGFIRQVKFLN-------------PPDAGPITVHCSAGAGRTGCFIAIDIMLDMAEN---EGVVDIFNCVRELRAQRVNMVQTEEQYVFVHDAILEACLxPTPrho_D1 (AAD50295) (175) HFTGWPDHGVPYH--ATGLLGFVRQVKSKS-------------PPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAER---EGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLhPTPmu_D1 (NP_002836) PTPRM (175) HFTGWPDHGVPYH--ATGLLGFVRQVKSKS-------------PPNAGPLVVHCSAGAGRTGCFIVIDIMLDMAER---EGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLmPTPmu_D1 (NP_033010) Ptprm (175) HFTGWPDHGVPYH--ATGLLSFIRRVKLSN-------------PPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAER---EGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLhPTPkappa_D1 (NP_002835) PTPRK (175) HFTGWPDHGVPYH--ATGLLSFIRRVKLSN-------------PPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAER---EGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLmPTPkappa_D1 (NP_033009 (revised)) Ptprk (175) HFTAWPEHGVPYH--ATGLLAFIRRVKAST-------------PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC---EGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLhPTPlamda_D1 (NP_005695) PTPRU (171) HFTAWPEHGVPYH--ATGLLAFIRRVKAST-------------PPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAEC---EGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLmPTPlamda_D1 (NP_035344) Ptprl (171) HFTAWPEHGVPYH--ATGLLAFIRRVKAST-------------PPDAGPVVIHCSAGTGRTGCYIVLDVMLDMAEC---EGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILE---rPTPpsi_D1 (AAB42210) Ptpru Fragm (171) HFTSWPDFGVPFT--PIGMLKFLKKVKTCN-------------PQYAGAIVVHCSAGVGRTGTFIVIDAMLDMMHA---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLcPTPalpha_D1 (AAB04150) (181) HFTSWPDFGVPFT--PIGMLKFLKKVKACN-------------PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHT---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLhPTPalpha_D1 (NP_002827) PTPRA (181) HFTSWPDFGVPFT--PIGMLKFLKKVKACN-------------PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHS---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLmPTPalpha_D1 (AAK56109) Ptpra (181) HFTSWPDFGVPFT--PIGMLKFLKKVKACN-------------PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHS---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLrPTPalpha_D1 (NP_036895) Ptpra (181) HFTSWPDFGVPFT--PIGMLKFLKKVKNCN-------------PQYAGPIVVHCSAGVGRTGTFIVIDAMLDMMGA---ERKVDVFGFVTRIRAQRCQMVQTDMQYVFIFQALLEHYLzPTPalpha_D1 (NP_571963) ptpra (181) HFTSWPDFGVPFT--PIGMLKFLKKVKNCN-------------PQYAGAIVVHCSAGVGRTGTFMVIDAMLDMMNT---EKKVDVYGFVTRIRAQRCQMVQTDMQYVFIYQALLEHFLxPTPalpha_D1 (AAA17990) (181) HFTSWPDFGVPFT--PIGMLKFLKKVKTLN-------------PVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHA---EQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLhPTPepsilon_D1 (NP_006495) PTPRE (180) HFTSWPDFGVPFT--PIGMLKFLKKVKTLN-------------PSHAGPIVVHCSAGVGRTGTFIVIDAMMDMIHS---EQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLmPTPepsilon_D1 (NP_035342) Ptpre (180) HFTSWPDFGVPFT--PIGMLKFLKKVKTLN-------------PSHAGPIVVHCSAGVGRTGTFIVIDAMMDMIHS---EQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLrPTPepsilon_D1 (XP_215102) Ptpre (180) HYTQWPDMGVPEY--ALPVLTFVRRSSAAR-------------MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKD---KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILhPTPgamma_D1 (NP_002832) PTPRG (192) HYTQWPDMGVPEY--ALPVLTFVRRSSAAR-------------MPDMGPVLVHCSAGVGRTGTYIVIDSMLQQIKD---KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILmPTPgamma_D1 (NP_033007) Ptprg (192) HYTQWPDMGVPEY--ALPVLTFVRRSSAAR-------------MPDMGPVLVHCSAGVGRTGTYIVIDSMLQQIKD---KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILrPTPgamma _D1 (NP_599183) Ptprg (196) HYTQWPDMGVPEY--ALPVLTFVRRSSAAR-------------TPHMGPVVVHCSAGVGRTGTYIVIDSMLQQIKD---KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILcPTPgamma_D1 (Q98936) (192) HYTQWPDMGVPEY--SLPVLTFVRKAAYAK-------------RHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQH---EGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILhPTPzeta_D1 (NP_002842) PTPRZ1 (194) HYTQWPDMGVPEY--SLPVLAFVRKTAQAK-------------RHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQH---EGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILrPTPzeta_D1 (NP_037212) Ptprz1 (194) HYTQWPDMGVPEY--TLPVLTFVRKASHAK-------------RHAVGPIVVHCSAGVGRTGTYVVLDSMLQQIQH---EGTVNIFGFLKHIRTQRNYLVQTEEQYIFIHDALVEAILcPTPzeta_D1 (AAA49015) (187) HYTQWPDMGVPEY--TLPVLTFVRKASAT---------------KLNGPVVVHCSAGVGRTGTYIVLDSMLQQIQH---EGTVNIFGFLKHIRSQRNYLVQTEEQYIFIHDALVEAILxPTPzeta_D1 (BAA97445) (187) QFTSWPDHGVPED--PHLLLKLRRRVNAFS-------------NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEA---ENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQhCD45_D1 (NP_002829) PTPRC (180) QFTSWPDHGVPED--PHLLLKLRRRVNAFS-------------NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEA---EGKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQmCD45_D1 (NP_035340) Ptprc (180) QFTSWPDHGVPED--PHLLLKLRRRVNAFS-------------NFFSGPIVVHCSAGVGRTGTYIGIDAMLESLEA---EGKVDVYGYVVNLRRQRCLMVQVEAQYILIHQALVEYNQrCD45_D1 (XP_213985) Ptprc (180) QFTSWPDHGVPED--PHLLLKLRRRVNALS-------------NFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLDA---EGRVDVYGYVVKLRRQRCLMVQVESQYILIHQALVEYHQcCD45_D1 (A54080) (180) QFISWPDHGVPGD--PSLLLKLRRRVNSFK-------------NFFSGPVVVHCSAGVGRTGTYMSIDAMIESLEA---EGRVDIYGFVAKLRRQRCLMVQVEAQYILIHTALIEYNQcypcaCD45_D1 (BAA92179) (177) QFMSWPDHGVPEE--AQLLLKLRRRVNSFK-------------NFFSGPIVVHCSAGVGRTGTYIGIDAMMESLEA---EGRVDIYGYVVMLRRQRCLMVQVEAQYILIHQALLEHTQfuCD45_D1 (CAB96211) (180) QFIRWPDHGVPED--PHLLLKLRQRVNAFR-------------NLFSGPIVVHCSAGVGRTGSYIGIDAMMQGLEA---EGRVDVYGYIVQLRRQRCLMVQVEAQYILIHQALLEYYLsharkCD45_D1 (T43148) (180) HFTSWPDHGVPDT--TDLLINFRYLVRDYMKQ-----------SPPESPILVHCSAGVGRTGTFIAIDRLIYQIEN---ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRhDEP1_D1 (NP_002834) PTPRJ (176) HFTSWPDHGVPDT--TDLLINFRYLVRDYMKQ-----------IPPESPILVHCSAGVGRTGTFIAIDRLIYQIEN---ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRrDEP1_D1 (NP_058965) Ptprj (176) HFTSWPDHGVPDT--TDLLINFRYLVRDYMKQ-----------IPPESPILVHCSAGVGRTGTFIAIDRLIYQIEN---ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRmDEP1_D1 (NP_033008) Ptprj (176) NYTAWPDHGVPTANAAESILQFVHMVRQQAT-------------KSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD---HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMhGLEPP1_D1 (NP_109592) PTPRO (176) NYTAWPDHGVPPANAAESILQFVYTVRQQAT-------------KSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD---HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWLrGLEPP1_D1 (NP_059032) Ptpro (176) NYTGWPDHGVPPANAAESILQFVFTVRQQAA-------------KSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD---HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWLmPTPphi_D1 (NP_035346) Ptpro (176) NYTAWPDHGVPTANAAESILQFVHMVRQQAT-------------KSKGPMIIHCSAGVGRTGTFIALDRLLQHIRD---HEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMrabPTPoc_D1 (AAB16824) (176) HYTVWPDHGVPET--TQSLIQFVRTVRDYINR-----------SPGAGPTVVHCSAGVGRTGTFIALDRILQQLDS---KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRhPTPbeta_D1 (NP_002828) PTPRB (179) HYTVWPDHGVPET--TQSLIQFVRTVRDYINR-----------SPGAGPTVVHCSAGVGRTGTFVALDRILQQLDS---KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRmPTPbeta_D1 (NP_084204) Ptprb (179) HYTVWPDHGVPET--TQSLIQFVRTVRDYINR-----------SPGAGPTVVHCSAGVGRTGTFVALDRILQQLDS---KDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRrPTPbeta_D1 (XP_235156 (revised)) (179) NFTAWPEHGVPEN--SAPLIHFVKLVRASR-------------AHDTTPMIVHCSAGVGRTGVFIALDHLTQHIND---HDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLShPTPS31_D1 (AR073855) PTPGMC1 (177) NFTGWPEHGVPEN--TTPLIHFVKLVRTSR-------------AHDTTPMVVHCSAGVGRTGVFIALDHLTQHINN---HDFVDIYGLVAELRSERMCMVQNLAQYIFLHQCILDLLSrPTPGMC1_D1 (NP_075214) Ptprq (177) HYQAWPDHGVPSS--PDTLLAFWRMLRQWLDQ-----------TMEGGPPIVHCSAGVGRTGTLIALDVLLRQLQS---EGLLGPFSFVRKMRESRPLMVQTEAQYVFLHQCICGSSNhSAP1_D1 (NP_002833) PTPRH (178) HYLAWPDHGVPYS--PDPLLAFRKMLRQWMDQ-----------TTDGGPPIVHCSAGVGRTGTLIALDVLLRQLEC---EGLVGPFSFVKKMRESRPLMVQTEAQYVFLHQCILKSLQmSAP1_D1 (BAC37443) (178) HYVAWPDHGVPYS--PDPLLAFQKLLRQWLDQ-----------TMDGGPPIVHCSAGVGRTGTLIALDVLLRQLEC---EGLVDPFSFVKKMRESRPLMVQTEAQYVFLHQCILRSLQrPTPBEM2_D1 (NP_598276) (178) QFTTWPDHSVPEA--PSSLLAFVELVQEEVKA-----------TQGKGPILVHCSAGVGRTGTFVALLPAVRQLEE---EQVVDVFNTVYILRLHRPLMIQTLSQYIFLHSCLLNKILmPTPESP_D1 (NP_031981) Esp (178)

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VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

QFTTWPDHSVPEA--PSSLLAFVELVQEQVQA-----------TQGKGPILVHCSAGVGRTGTFVALLRLLRQLEE---EKVADVFNTVYILRLHRPLMIQTLSQYIFLHSCLLNKILrOSTPTP_D1 (NP_149090) Esp (178) WYTSWPDHKTPDS--AQPLLQLMLDVEEDRLA-----------SQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKE---EGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYEShPCPTP1_D1 (NP_002840) PTPRR (174) WYTSWPDHKTPDS--AQPLLQLMLDVEEDRLA-----------SEGRGPVVVHCSAGIGRTGCFIATSIGCQQLKE---EGVVDALSIVCQLRVDRGGMVQTSEQYEFVHHALCLFESrPCPTP1_D1 (NP_446046) Ptprr (174) WYTSWPDHKTPDS--AQPLLQLMLDVEEDRLA-----------SEGRGPVVVHCSAGIGRTGCFIATSIGCQQLKE---EGVVDALSIVCQLRVDRGGMVQTSEQYEFVHHALCLFESmPTPSL_D1 (NP_035347) Ptprr (174) WFTSWPDQKTPDR--APPLLHLVREVEEAAQQE----------GPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ---EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKhSTEP_D1 (NP_116170) PTPN5 (174) WFTSWPDQKTPDR--APPLLHLVREVEEAAQQE----------GPHCSPIIVHCSAGIGRTGCFIATSICCQQLRR---EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKmSTEP_D1 (NP_038671) Ptpn5 (174) WFTSWPDQKTPDR--APPLLHLVREVEEAAQQE----------GPHCSPIIVHCSAGIGRTGCFIATSICCQQLRR---EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHAMSLYEKrSTEP_D1 (NP_062126) Ptpn5 (174) LFSAWPDHQTPES--AGPLLRLVAEVEESPET-----------AAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKA---RGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGhHePTP_D1 (NP_002823) PTPN7 (172) LFSAWPDHQTPES--AGPLLRLVAEVETP-ET-----------AANSGPIVVHCSAGIGRTGCFIATRIGCQQLKA---RGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAAmHePTP_D1 (NP_796055) Ptpn7 (172) LFSAWPDHQTPES--AGPLLRLVAEVETP-ET-----------AANSGPIVVHCSAGIGRTGCFIATRIGCQQLKA---RGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAArLCPTP_D1 (P49445) Ptpn7 (172) HYKNWPDHDVPSS-----IDPILELIWDVRCYQ----------EDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKhLyPTP_D1 (NP_057051) PTPN22 (185) HYKNWPDHDVPSS-----IDPILQLIWDMRCYQ----------EDDCVPICIHCSAGCGRTGVICAVDYTWMLLKDGIIPKNFSVFNLIQEMRTQRPSLVQTQEQYELVYSAVLELFKmPEP_D1 (NP_033005) Ptpn8 (185) HYVNWPDHDVPSS-----FDSILDMISLMRKYQ----------EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEhPEST_D1 (NP_002826) PTPN12 (189) HYVNWPDHDVPSS-----FDSILDMISLMRKYQ----------EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFErRKPTP_D1 (NP_476456) Ptpn12 (189) HYVNWPDHDVPSS-----FDSILDMISLMRKYQ----------EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEmPEST_D1 (NP_035333) Ptpn12 (189) QYMSWPDRGVPSS--PDHMLAMVEEARRLQG-------------SGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFChBDP1_D1 (NP_055184) PTPN18 (186) QYMSWPDHGVPSS--SDHILTMVEEARCLQG-------------LGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFQVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSmPTPK1_D1 (NP_035336) Ptpn18 (186) QYMSWPDHGVPSS--SDHILTMVEEARCLQG-------------LGPGPLCVHCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFEVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSrPTP20_D1 (AAC52896) (186) QYLSWPDHGVPSE--PGGVLSFLDQINQRQES-----------LPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIEhSHP1_D1 (NP_002822) PTPN6 (193) QYLSWPDHGVPSE--PGGVLSFLDQINQRQES-----------LPHAGPIIVHCSAGIGRTGTIIVIDMLMESISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIEmSHP1_D1 (NP_038573) Hcph (193) QYLSWPDHGVPSE--PGGVLSFLDQINQRQES-----------LPHAGPIIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIErSHP1_D1 (NP_446360) Ptph6 (193) QYLSWPDHGVPQE--PGGVLSFLDQVNRKQEE-----------LRSSAPIVIHCSAGIGRTGTIVVIDMLIDSIDAKGLDCDIDIQKCIMMVRDQRSGMVQTEAQYKFIYLAVLQYVEzSHP1_D1 (AAH44414) (193) QYLSWPDHGVPNE--PGGVLSFLDQVNRTQQS-----------IPDTGPIIVHCSAGIGRTGTIIVIDMLISDISRQGLDCDIDIPKTIQIVRKQRSGMVQTEAQYKFIYMAVQQYIEryPTPN6c_D1 (BAA95199) (162) HFRTWPDHGVPSD--PGGVLDFLEEVHHKQES-----------IMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIEhSHP2_D1 (NP_002825) PTPN11 (196) HFRTWPDHGVPSD--PGGVLDFLEEVHHKQES-----------IVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIEmSHP2_D1 (NP_035332) Ptpn11 (200) HFRTWPDHGVPSD--PGGVLDFLEEVHHKQES-----------IVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIErSHP2_D1 (NP_037220) Ptpn11 (196) HFRTWPDHGVPSD--PGGVLDFLEEVHHKQES-----------ISDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIEcSHP2_D1 (JC5167) (196) HFRAWPDHGVPGD--PGGVLDFLEEVKLKQEG-----------ITGAGPIVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIEzSHP2_D1 (AAH45328) (196) HFKTWPDHGVPAD--PGGVLDFLEEVHHKQDG-----------ITDAGPVVVHCSAGIGRTGTFIVIDILIDVIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIExSHP2_D1 (A55651) (196) HFKTWPDHGVPSD--PGGVLDFLEEVNIKQEN-----------IPEAGPIVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKSIQMVRSQRSGMVQTEAQYRFIYMAVQHYIEryPTPN6b_D1 (BAA95198) (167) QYTDWPEHGCPED--LKGFLSYLEEIQSVRRHTNSTS---D-PQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHN---EVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKhPTPD1_D1 (NP_008970) PTPN21 (184) QYTDWPEHGCPED--LKGFLSYLEEIQSVRRHTNSTS---E-PKSHNPPLLVHCSAGVGRTGVVILSEIMVACLEHN---EVLDIPRVLDMLRQQRMMLVQTLGQYTFVYRVLIQFLKmPTPRL10_D1 (NP_036007) Ptpn21 (184) QYTDWPEHGCPED--LKGFLSYLEEIQSVRRHTNSTS---E-PRSPNPPLLVHCSAGVGRTGVVILSEIMVACLEHN---EVLDIPRVLELLRQQRMMLVQTLSQYTFVYRVLIQFLKrPTP2E_D1 (NP_598229) Ptp2E (184) QYTDWPDHGCPED--VQGFLSYLEEIQSVRRHTNSML---EGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHN---EKVEVPMMLRLLREQRMFMIQTIAQYKFVYQVLIQFLQhPTPD2_D1 (NP_005392) PTPN14 (183) QYTDWPHHGCPED--VQGFLSYLEEIQSVRRHTNSVL---EGIRTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHN---EKVEVPTMLRFLREQRMFMIQTIAQYKFVYQVLVQFLQmPTP36_D1 (NP_033002) Ptpn14 (183) QYTDWPHHGCPED--VQGFLSYLEEIQSVRRHTNSVL---EGVKTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHNEKATKVEVPTMLRFLREQRMFMIQTIAQYKFVYQVLVQFLQrPTPD2_D1 (XP_223062 (revised)) (183) QYIAWPDHGVPDD--SSDFLDFVCHVRNKR-------------AGKEEPVVVHCSAGIGRTGVLITMETAMCLIECN---QPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEhMEG1_D1 (NP_002821) PTPN4 (178) QYTAWPDHGVPDD--SSDFLDFVCHVRDQR-------------AGKEEPIIVHCSAGIGRTGVLITMETAMCLIECN---QPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEmMEG1_D1 (NP_064317) Ptpn4 (178) QYLAWPDHGVPDD--STDFLDFVALVRNKR-------------AGKDEPVVVHCSAGIGRTGVLITMETAMCLMECS---QPVFPLEIVRTMRDQRAMMIQTPSQFKFVCEAILKVYEzMEG1_D1 (CAD43435) (173) QYVAWPDHGVPDD--SSDFLEFVNYVRSLR--------------VDSEPLLVHCSAGIGRTGVLVTMETAMCLTERN---LPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEhPTPH1_D1 (NP_002820) PTPN3 (178) QYVAWPDHGVPDD--SSDFLEFVKYVRSLR--------------VDGEPALVHCSAGIGRTGVLVTMETAMCLIERN---LPVYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEmPTPH1_D1 (XP_143789) Ptpn3 (178) NFTAWPDHDTPSQ--PDDLLTFISYMRHI---------------HRSGPIITHCSAGIGRSGTLICIDVVLGLISQD---LDFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLThPTPBAS_D1 (NP_006255) PTPN13 (178) NFTAWPDHDTPSQ--PDDLLTFISYMRHI---------------RRSGPVITHCSAGIGRSGTLICIDVVLGLISQD---LEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVILYVLTmPTPBL_D1 (NP_035334) Ptpn13 (178) NFTAWPDHDTPSQ--PDDLLTFISYMRHV---------------HRSGPIITHCSAGIGRSGTLICIDVVLGLISQD---LEFDISDLVRCMRLQRHGMVQTEDQYIFCYQVILYVLTbPTPBA14_D1 (NP_777015) PTPN13 (178) QFTKWPDHGTPAS--ADSFIKYIRYARKS---------------HLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKD---CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRhPTPTyp_D1 (AL050040) PTPN20 (177) QFTKWPDHGTPAS--ADFFIKYVRYVRKS---------------HITGPLLVHCSAGVGRTGVFICVDVVFSAIEKN---YSFDIMNIVTQMRKQRCGMIQTKEQYQFCYEIVLEVLQmPTPTyp_D1 (NP_033004) Ptpn20 (176) HYTTWPDFGVPES--PASFLNFLFKVRESGS-----------LNPEYGPVVVHCSAGIGRSGTFCLVDTCLLLMDKRKDPSSVDVKQVLLEMRKYRMGLIQTADQLRFSYLAVIEGAKcPTP1B_D1 (O13016) (175) HYTTWPDFGVPES--PASFLNFLFKVRESGS-----------LSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKhPTP1B_D1 (NP_002818) PTPN1 (175) HYTTWPDFGVPES--PASFLNFLFKVRESGS-----------LSLEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKmPTP1B_D1 (NP_035331) Ptpn1 (175) HYTTWPDFGVPES--PASFLNFLFKVRESGS-----------LSPEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKrPTP1B_D1 (NP_036769) Ptpn1 (175) HYTTWPDFGVPES--PASFLNFLFKVRESGC-----------LSPELGPVVVHCSAGIGRSGTFCLVDTCLLLMSQRKDPSSVRIQEVLLEMRRYRMGLIQTADQLRFSYLAFIEGAKzPTP1B_D1 (NP_570999) ptp1b (173) HYTTWPDFGVPES--PASFLNFLFKVRESGS-----------LNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKG---DDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKhTCPTP_D1 (NP_002819) PTPN2 (174) HYTTWPDFGVPES--PASFLNFLFKVRESGC-----------LTPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKG---EDVNVKQLLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKmTCPTP_D1 (NP_033003) Ptpn2 (174) HYTTWPDFGVPES--PASFLNFLFKVRESGS-----------LNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKG---EDVNVKQILLSMRKYRMGLIQTPDQLRFSYMAIIEGAKrTCPTP_D1 (NP_446442) Ptpn2 (174) HYTTWPDFGVPES--PASFLNFLFKVRESGS-----------LGMEQGPAVVHCSAGIGRSGTFSLVDTCLVLMDKRKDPLLVDIKKILLDMRKYRMGLIQTPDQLRFSYMAVLEGAKzTCPTP_D1 (AAH44373) (173) QFLSWPDYGVPSS--AASLIDFLRVVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEEL---GTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEhMEG2_D1 (NP_002824) PTPN9 (179) QFLSWPDYGVPSS--AASLIDFLRVVRNQQSMAVGNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEEL---GTLNVFHTVSRMRTQRAFSIQTPEQYYFCYKAILEFAQmMEG2_D1 (NP_062625) Ptpn9 (179) QYMSWPDFGVPKS--ASAMLDFRSQVKQHQAVAVQNLGMEWTGHPAGPPIVVHCSAGIGRTGTFCTLDICLSRLEDI---GTVDVLQTVKRMRTQASFSIQTWDQYYFCYMAIIEYAQxPTPX10_D1 (B53978) (179) QYMSWPDFGVPKS--ASAMLDFRTQVKQHQAVAVQALGMAWTGHPAGPPVVVHCSAGIGRTGTFCTLDICLSRLEDI---GTVDVLQTVKRMRTQRAFSIQTWDQYYFCYMAIIEYAQxPTPX1_D1 (AAH43621) (179) HFPTWPELGLPDS--PSNLLRFIQEVHAHYLHQR----------PLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAG--NGIPELPQLVRRMRQQRKHMLQEKLHLRFCYEAVVRHVEhHDPTP_D1 (NP_056281) PTPN23 (183) HFPTWPELGLPDS--PGNLLRFIQEVHAHYLHQR----------PLHTPIVVHCSSGVGRTGAFALLYAAVQEVEAG--NGIPELPQLVRRMRQQRKHMLQEKLHLKFCHEALVRHVEmHDPTP_D1 (AAH22721) (183) HFPTWPELGLPDS--PGNLLRFIQEVHAHYLHQR----------PLHTPIVVHCSSGVGRTGAFALLYAAVQEVEAG--SRIPELPQLVRRMRQQRKHMLQEKLHLKVLPRGIGATCGrPTPTD14_D1 (T14355) (183) HFLSWPAEGTPAS--TRPLLDFRRKVNKCYR-------------GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKG--VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNhIA2_D1 (NP_002837) PTPRN (179) HFLSWPAEGTPAS--TRPLLDFRRKVNKCYR-------------GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKG--VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNmIA2_D1 (NP_033011) Ptprn (179) HFLSWPAEGTPAS--TRPLLDFRRKVNKCYR-------------GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKG--VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNrIA2_D1 (NP_446333) Ptprn (179)

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VectorNTI Screen View - Alignment_195_Vert_PTP_Domains_D1_and_D2 (VNTI 8.0).apr

HFLSWPAEGTPAS--TRPLLDFRRKVNKCYR-------------GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKG--VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNbIA2_D1 (P56722) Ptprn (179) HFLSWYDRGVPSS--SRSLLDFRRKVNKCYR-------------GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG--AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNhIA2beta_D1 (NP_002838) PTPRN2 (179) HFLSWYDRGVPSS--SRSLLDFRRKVNKCYR-------------GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG--AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNmacneIA2beta_D1 (O02695) (179) HFLSWYDQGVPSS--TRSLLDFRRKVNKCYR-------------GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG--AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNmPTPNP_D1 (P80560) Ptprn2 (179) HFLSWYDQGVPSS--TRSLLDFRRKVNKCYR-------------GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG--AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNrPTPNE6_D1 (NP_113788) Ptprn2 (179) QYTNWSVEQLPAE--PKELISMIQVVKQKLPQKNSSEGN---KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAET---EEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPhCD45_D2 (NP_002829) PTPRC (199) QCTTWKGEELPAE--PKDLVSMIQDLKQKLPKASPEGM----KYHKHASILVHCRDGSQQTGLFCALFNLLESAET---EDVVDVFQVVKSLRKARPGVVCSYEQYQFLYDIIASIYPmCD45_D2 (NP_035340) Ptprc (199) QCTTWKGEELPAE--PKDLVTLIQNIKQKLPKSGSEGM----KYHKHASILVHCRDGSQQTGLFCALFNLLESAET---EDVVDVFQVVKSLRKARPGMVGSFEQYQFLYDIMASIYPrCD45_D2 (XP_213985) Ptprc (199) QYHKWNGLDVPED--PKDLVDMILSLKQKVPSRPASEDS---RNSRSVPFVIHCCDGSQQTWCVLCLMTLLESAET---EEVIDVFQVVKALRRSRLGVVSTFEQYQFLYDTIARTYPcCD45_D2 (A54080) (199) QFLKWGDKEVPEK--PQDLADLIKEIKHRCGY----------TWPRSTPIIVHCNDGSSRSGAFCALWNLLDNAEK---EKMVDVFQVVKTLRKERQGMCPSLEQYQFLYDALEVVYPfuCD45_D2 (CAB96211) (199) QFLKWRGRELPEN--AQELVEMASIIRENGHYDNS-------KTNRNVPIVVHCNNGSSRTGIFCALWNLLDSAYT---EKLVDVLQEVKNLRKLRQGMVETIEQYQFLYTALEGAFPcypcaCD45_D2 (BAA92179) (197) QYTNWSVXXLPAX--PKELISMIQVXKQKLPQKNSSEGN---KXHKSXPLLIHCRDGSQQTGIFCALLNLLESAET---EEVVDXFQVVKALRKARPGMXSTFEQXQFLYDXIASTYPaotvoCD45_D2 (AAM48512) (3') (191) HFHDWAESELPED--PSNFTKMIRSIKEKLSTLQEPE------SSLSPSLIVHCSDGAKKTGVFYALWILLDNADT---ENVIDVLQTVKVLRKARPGLVSTFEQYQFLYDIIASTYPsharkCD45_D2 (T43148) (198) HFHGWPEVGIPSD--GKGMINIIAAVQKQQQ------------QSGNHPMHCHCSAGAGRTGTFCALSTVLERVKA---EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDcPTPalpha_D2 (AAB04150) (181) HFHGWPEVGIPSD--GKGMISIIAAVQKQQQ------------QSGNHPITVHCSAGAGRTGTFCALSTVLERVKA---EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDhPTPalpha_D2 (NP_002827) PTPRA (182) HFHGWPEVGIPSD--GKGMINIIAAVQKQQQ------------QSGNHPITVHCSAGAGRTGTFCALSTVLERVKA---EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDmPTPalpha_D2 (NP_033006) Ptpra (182) HFHGWPEVGIPSD--GKGMINIIAAVQKQQQ------------QSGNHPITVHCSAGAGRTGTFCALSTVLECVKA---EGILDVFQTVKTLRLQRPHMVQILEQYEFCYKVVQEYIDrPTPalpha_D2 (NP_036895) Ptpra (182) HFHGWPEVGIPTD--GKGMINIIAAVQKQQQ------------QSGNHPITVHCSAGAGRTGTFCALSTVLERVKA---EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYRVVQEYIDxPTPalpha_D2 (AAA17990) (182) HFHGWPEVGIPSD--GKGMINIIAAVQKQQQ------------QSGNHPITSHCSAGAGRTGTFCALSTVLERVKA---EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDzPTPalpha_D2 (NP_571963) ptpra (182) HFHGWPEVGIPAD--GKGMINLIAAVQKQQQ------------QSGNHPITVHCSAGAGRTGTFCALSTVLERVKA---EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDryPTPR4b_D2 (BAA95196) (182) HFHGWPEIGIPAE--GKGMIDLIAAVQKQQQ------------QTGNHPITVHCSAGAGRTGTFIALSNILERVKA---EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDhPTPepsilon_D2 (NP_006495) PTPRE (187) HFHGWPEVGIPAE--GKGMIDLIAAVQKQQQ------------QTGNHPITVHCSAGAGRTGTFIALSNILERVKA---EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDmPTPepsilon_D2 (NP_035342) Ptpre (187) HFHGWPEVGIPTE--GKGMIDLIAAVQKQQQ------------QTGNHPITVHCSAGAGRTGTFIALSNILERVKA---EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDrPTPepsilon_D2 (XP_215102) Ptpre (187) HFHGWPEIGIPVD--GRGMIDIIAAVQRQQQ------------QSGNRPIIVHCSAGAGRTGTFIALSNILERVKA---EGLLDVFQTVKSLRMQRPHMVQTVEQYDFCYKVVQDFIDorylaPTPepsilon_D2 (BAC06424) (187) HFHDWPEIGIPAE--GKGMIDLIAAVQKQQQ------------KSGNHPIIVHCSAGAGRTGTFIALSNILERVKA---EGLLDVFQTVKSLRMQRPHMVQTLEQYDFCYKVVQDFLDryPTPR4a_D2 (BAA95190) (182) QYLGWASHREVPGS-KRSFLKLILQVEKWQEEC----------EEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKR---QNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLEhPTPkappa_D2 (NP_002835) PTPRK (180) QYLGWASHREVPGS-KRSFLKLILQVEKWQEEC----------EEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKR---QNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLEmPTPkappa_D2 (NP_033009) Ptprk (180) QYLGWAAHREIPAS-KRSFLKLILQVDKWQEEC----------EEGEGRTIIHCLNGGGRSGMFCAITIICEMIKR---QNVVDIFHGVKTLRNSRPNMVETLDQYRFCYDVALEYLEryPTPR2B_D2 (BAA95194) (180) QFLRWSAYRDTPDS-KKAFLHLLAEVDKWQAES------------GDGRTIVHCLNGGGRSGTFCACATVLEMIRC---HNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEhPTPlamda_D2 (NP_005695) PTPRU (183) QFLRWSAYRDTPDS-RKAFLHLLAEVDKWQAES------------GDGRTVVHCLNGGGRSGTFCACATVLEMIRC---HSLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYLEmPTPlamda_D2 (NP_035344) Ptprl (183) QFLGWPMYRDTPVS-KRSFLKLIRQVDKWQEEYN----------GGEGPTVVHCLNGGGRSGTFCAISIVCEMLRH---QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNhPTPmu_D2 (NP_002836) PTPRM (180) QFLGWPMYRDTPVS-KRSFLKLIRQVDKWQEEYN----------GGEGPTVVHCLNGGGRSGTFCAISIVCEMLRH---QRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNmPTPmu_D2 (NP_033010) Ptprm (180) QFLGWPMYRDTPVS-KRSFLKLIRQVDKWQEEYN----------GGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH---QRTVDVFHAVKTLRNNKPNMVDLLQSWSSRETRALVLSSrPTPmu_D2 (XP_237546 (revised)) (180) QYIGWPAYRDTPPS-KRSLLKVVRRLEKWQEQYD----------GREGRTVVHCLNGGGRSGTFCAICSVCEMIQQ---QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLShPTPrho_D2 (NP_573400) PTPRT (180) QYIGWPAYRDTPPS-KRSLLKVVRRLEKWQEQYD----------GREGRTVVHCLNGGGRSGTFCAICSVCEMIQQ---QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSmPTPrho_D2 (NP_067439) Ptprt (180) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQP-AMVQTEDEYQFCYQAALEYLGcPTPsigma_D2 (I50212) (182) QFTDWPEQGVPKT--GEGFIDFIGQVHKTKEQFG-----------QDGPITVHCSAGVGRTGVFITLSIVLERMRY---EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGhLAR_D2 (NP_002831) PTPRF (182) QFTDWPEQGVPKT--GEGFIDXIGQVHKTKEQFG-----------QDGPITVHCSAGVGRTGVFITLSIVLERMRY---EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGmLAR_D2 (NP_035343) Ptprf (182) QFTDWPEQGVPKT--GEGFIDFIGQVHKTKEQFG-----------QDGPITVHCSAGVGRTGVFITLSIVLERMRY---EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGrLAR_D2 (NP_062122) Ptprf (182) QFTDWPEQGVPKT--GEGFIDFIGQVHKTKEQFG-----------QDGPITVHCSAGVGRTGVFITLSIVLERMRY---EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGxLAR_D2 (AAF43606) (182) QFTDWPEQGVPKT--GEGFIDFIGQVHKTKEQFG-----------QDGPITVHCSAGVGRTGVFITLSIVLERMRY---EGVVDMFQTIKTLRTQRPAMVQTEDQYQLCYRAALEYLGzLAR_D2 (CAC44758) (182) HFIDWPEQGVPKT--GEGFIDFIGQVHKTKEQFG-----------QDGPITVHCSAGVGRTGVFITLSIVLERMRY---EGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGryPTPR2Aa_D2 (BAA95188) (182) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGhPTPdelta_D2 (NP_002830) PTPRD (182) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGmPTPdelta_D2 (D54689) (181) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQRPAVVQTEDQYQFCYRAGLEYLGxPTPdelta_D2 (AAF43605) (182) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGryPTPR2Ab_D2 (BAA95191) (182) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGhPTPsigma_D2 (NP_002841) PTPRS (182) QFTDWPEQGAPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKVLRTQRPAMVQTEDEYQFCFQAALEYLGmPTPsigma_D2 (NP_035348) Ptprs (182) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGxPTPsigma_D2 (AAF43607) (182) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGzPTPsigma_D2 (CAC44759) (182) QFTDWPEQGAPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKVLRTQRPAMVQTEDEYQFCFQAALEYLGrPTPsigma_D2 (NP_062013) Ptprd (182) QFTDWPEQGVPKS--GEGFIDFIGQVHKTKEQFG-----------QDGPISVHCSAGVGRTGVFITLSIVLERMRY---EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGryPTPR2Ac_D2 (BAA95193) (182) QCPKWPNPDAPIS----STFELINVIKEEALT-------------RDGPTIVHDEYGAVSAGMLCALTTLSQQLEN---ENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKARLSLVShPTPgamma_D2 (NP_002832) PTPRG (186) QCPKWPNPDAPIS----STFELINVIKEEALT-------------RDGPTIVHDEYGAVSAGMLCALTTLSQQLEN---ENAVDVFQVAKMINLMRPGVFTDIEQYQFVYKAMLSLISmPTPgamma_D2 (NP_033007) Ptprg (186) YVLEVRHFQAPIS----STFELINVIKEEALA-------------RDGPTIVHDEYGAVSAGMLCALTTLSQQLEN---ENAVDVFQVAKMINLMRPGVFTDIEQYQFVYKAMLSLVSrPTPgamma_D2 (NP_599183) Ptprg (178) QCPKWPNPDAPLS----STFELINVLKEEAST-------------RDGPTIVHDEFGGVSAGLFCGLTTLSQQLEC---ESAVDVYQVAKMINLMRPGVFTDIEQYQFLYKAMLSLISryPTPR5b_D2 (BAA95197) (186) QCPKWPNPDAPIS----STFELINVIKEEALT-------------RDGPTIVHDEYGAVSAGTLCALTTLSQQLEN---ENAVDVFQVAKMINLMRPGVFTDIEQYQFLYKAMLSLVScPTPgamma_D2 (Q98936) (186) QCPKWPNPDSPIS----KTFELISVIKEEAAN-------------RDGPMIVHDEHGGVTAGTFCALTTLMHQLEK---ENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVShPTPzeta_D2 (NP_002842) PTPRZ1 (185) QCPKWPNPDSPIS----KTFELISIIKEETSN-------------RDGPMIVHDEHGGVTAGTFCALTTLMHQLEN---ENSVDVYQVAKMINLMRPGVFTDIEQYQFLYKAILSLVScPTPzeta_D2 (AAA49015) (185) QCPKWPNPDSPIS----KTFELISIIKEEAAN-------------RDGPMIVHDEHGGVTAGTFCALTTLMHQLEK---ENAMDVYQVAKMINLMRPGVFTDIEQYQFLYKVVLSLVSmPTPzeta_D2 (XP_133009) Ptprz1 (185) QCPKWPNPDSPIS----KTFELISIIKEEAAN-------------RDGPMIVHDEHGGVTAGTFCALTTLMHQLEK---ENSMDVYQVAKMINLMRPGVFTDIEQYQFLYKVVLSLVSrPTPzeta_D2 (NP_037212) Ptprz1 (185) QCPKWPNPDSPIS----KTFELINLIKEEAAN-------------KDGTIIVHDEYGGVTAGTFCALYSLMHQLEQ---ENSLDVYQVVKMINLMRPGIFTDIEQYQFLYKAMLSLVSxPTPzeta_D2 (BAA97445) (185) QSPRWPNPDGPIS----KTFELLNLIRDAAAT-------------RDGPIIVHDEHGGITAGTFCALTKLMDQLES---ENSVDVYQVAKMINLMRPGIFTDIDQFQFLYKAILSLVNryPTPR5a_D2 (BAA95195) (181) QFT WPDHGVP LL FI V GPIVVHCSAGVGRTGTFI ID MLE L E VDVF VK LR QR MVQT EQY FIY ALLE L Consensus (237)

http://ptp.cshl.edu or http://science.novonordisk.com/ptp


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